Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

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Abstract

A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3–12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1–12) were determined by the extensive 1D, 2D-NMR, High resolution mass spectra (HRESIMS) data. Compounds 7, 8, 11 and 12 showed significant selective cytotoxicities against HeLa, DU145 and U937 cell lines. In addition, compounds 7, 8 and 11 also exhibited COX-2 inhibitory activities with the prominent IC50 values of 2.4, 7.1 and 10.6 μM, respectively.

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Acknowledgements

This work was supported by grants from the National Key Basic Research Program of China (973)’s Project (2011CB915503); the National High Technology Research and Development Program (863 Program, 2012AA092104), Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA11030403), the National Natural Science Foundation of China (31270402, 21172230, 41476135, 41376162, 41406187, 41406187); and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001), Guangzhou Scientific Research Project (2014J4100212).

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Correspondence to Zhengchao Tu or Yonghong Liu.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on The Journal of Antibiotics website

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