Bendigoles A~C, New Steroids from Gordonia australis Acta 2299

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Abstract

Bendigoles A~C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A~C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.

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Author information

Correspondence to Roderich D Süssmuth or Hans-Peter Fiedler.

Additional information

Art. No. 43 in 'Biosynthetic Capacities of Actinomycetes'. Art. No. 42: See ref. 1

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Schneider, K., Graf, E., Irran, E. et al. Bendigoles A~C, New Steroids from Gordonia australis Acta 2299. J Antibiot 61, 356–364 (2008) doi:10.1038/ja.2008.50

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Keywords

  • bendigole A
  • bendigole B
  • bendigole C
  • Gordonia
  • steroids
  • fermentation
  • isolation
  • structure elucidation

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