Sansanmycins B and C, New Components of Sansanmycins

Abstract

Two new antibiotics, sansanmycins B and C, were isolated from Streptomyces sp. SS. Their structures were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Sansanmycins B and C exhibited inhibitory activity against our test strain of Pseudomonas aeruginosa with MIC values of 8.0 and 16 μg/ml, respectively. Sansanmycin B also exhibited inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant Mycobacterium tuberculosis, with the MIC values ranging from 8.0 to 20 μg/ml.

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Correspondence to Ruxian Chen.

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Xie, Y., Xu, H., Si, S. et al. Sansanmycins B and C, New Components of Sansanmycins. J Antibiot 61, 237–240 (2008). https://doi.org/10.1038/ja.2008.34

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Keywords

  • sansanmycin B
  • sansanmycin C
  • structure elucidation
  • antibacterial activity
  • Mycobacterium tuberculosis

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