Abstract
Ascochytatin, a new spirodioxynaphthalene metabolite produced by a marine-derived fungus, was found from a screening program focused on the bacterial two-component regulatory system. The structure of ascochytatin was determined by spectroscopic methods, including NMR and MS. The relative stereochemistry was determined by an X-ray crystallographic analysis, and the absolute stereochemistry was determined by the modified Mosher's method.
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Kanoh, K., Okada, A., Adachi, K. et al. Ascochytatin, a Novel Bioactive Spirodioxynaphthalene Metabolite Produced by the Marine-derived Fungus, Ascochyta sp. NGB4. J Antibiot 61, 142–148 (2008). https://doi.org/10.1038/ja.2008.123
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DOI: https://doi.org/10.1038/ja.2008.123
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