Abstract
In our screening program we found an activity against some Gram-positive bacteria, including mycobacteria in the culture supernatant of Sorangium cellulosum strain So ce895. The antibiotic responsible for this activity was isolated and named thuggacin. Initial studies towards the mechanism of action showed that thuggacin A inhibits a late step of the respiratory chain of some bacteria.
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Irschik, H., Reichenbach, H., Höfle, G. et al. The Thuggacins, Novel Antibacterial Macrolides from Sorangium cellulosum Acting against Selected Gram-positive Bacteria. J Antibiot 60, 733–738 (2007). https://doi.org/10.1038/ja.2007.95
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DOI: https://doi.org/10.1038/ja.2007.95
Keywords
- Sorangium cellulosum
- antibiotics
- macrolides
- respiration
- thuggacin
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