Lepidepyrone, a New γ-Pyrone Derivative, from Neolentinus lepideus, Inhibits Hyaluronidase

The Journal of Antibiotics volume 60, pages388–390(2007)Cite this article

Abstract

In the course of screening for hyaluronidase (HAase) inhibitory agents, a new γ-pyrone derivative, lepidepyrone, C8H10O5, was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC50 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.

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Affiliations

  1. Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo, 142-8501, Japan

    Tomoo Hosoe, Hideo Sakai, Makoto Ichikawa, Takeshi Itabashi & Ken-ichi Kawai

  2. Tamagawa University Research Institute, Tamagawa-Gakuen 6-1-1, Machida, Tokyo, 194-8610, Japan

    Takayuki Ishizaki

Authors
  1. Tomoo Hosoe
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  2. Hideo Sakai
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  3. Makoto Ichikawa
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  4. Takeshi Itabashi
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  5. Takayuki Ishizaki
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  6. Ken-ichi Kawai
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Corresponding author

Correspondence to Tomoo Hosoe.

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Hosoe, T., Sakai, H., Ichikawa, M. et al. Lepidepyrone, a New γ-Pyrone Derivative, from Neolentinus lepideus, Inhibits Hyaluronidase. J Antibiot 60, 388–390 (2007). https://doi.org/10.1038/ja.2007.53

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Keywords

  • Neolentinus lepideus
  • γ-pyrone derivative
  • lepidepyrone
  • hyaluronidase inhibitor

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