Lepidepyrone, a New γ-Pyrone Derivative, from Neolentinus lepideus, Inhibits Hyaluronidase


In the course of screening for hyaluronidase (HAase) inhibitory agents, a new γ-pyrone derivative, lepidepyrone, C8H10O5, was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC50 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.


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Correspondence to Tomoo Hosoe.

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Hosoe, T., Sakai, H., Ichikawa, M. et al. Lepidepyrone, a New γ-Pyrone Derivative, from Neolentinus lepideus, Inhibits Hyaluronidase. J Antibiot 60, 388–390 (2007). https://doi.org/10.1038/ja.2007.53

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  • Neolentinus lepideus
  • γ-pyrone derivative
  • lepidepyrone
  • hyaluronidase inhibitor

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