Abstract
Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus jostii K01-B0171, which was isolated from soil aggregates collected in Yunnan, China. Lariains A and B showed growth inhibition against Mycobacterium smegmatis with MIC values of 3.13 and 6.25 μg/ml in agar dilution method, respectively. Furthermore, lariatin A inhibited the growth of Mycobacterium tuberculosis with an MIC of 0.39 μg/ml in liquid microdilution method.
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Iwatsuki, M., Uchida, R., Takakusagi, Y. et al. Lariatins, Novel Anti-mycobacterial Peptides with a Lasso Structure, Produced by Rhodococcus jostii K01-B0171. J Antibiot 60, 357–363 (2007). https://doi.org/10.1038/ja.2007.48
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DOI: https://doi.org/10.1038/ja.2007.48
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