A New Cadinane Sesquiterpene with Significant Anti-HIV-1 Activity from the Cultures of the Basidiomycete Tyromyces chioneus

Abstract

A new cadinane sesquiterpene (4β,14-dihydroxy-6α,7βH-1(10)-cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements (MS, IR, 1D and 2D NMR experiments). 1 showed significant anti-HIV-1 activity with EC50=3.0 μg/ml (SI=25.4).

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Correspondence to Ji-Kai Liu.

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Liu, DZ., Wang, F., Yang, LM. et al. A New Cadinane Sesquiterpene with Significant Anti-HIV-1 Activity from the Cultures of the Basidiomycete Tyromyces chioneus. J Antibiot 60, 332–334 (2007). https://doi.org/10.1038/ja.2007.44

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Keywords

  • Tyromyces chioneus
  • culture broth
  • cadinane sesquiterpene
  • anti-HIV-1

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