Abstract
A new compound named 4849F was isolated from the Streptomyces sp. 4849. The structure of 4849F was elucidated by spectroscopic analyses. The immobilized ligand-binding assay showed that 4849F can competitively inhibit the binding of IL-4 with IL-4 receptor in a dose dependent manner with an IC50 value of 6.7 μM.
Similar content being viewed by others
Article PDF
References
Chol P, Reiser H . IL-4: role in disease and regulation of production. Clin Exp Immunol 113: 317–319 ( 1998)
Paul WE . Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77: 1859–1870 ( 1991)
Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt MC, Gundel R, Gelfand EW . A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J Immunol 166 ( 9): 5792–5800 ( 2001)
Zhang Y, Wang WC, Li Y . Cloning, expression, and purification of soluble human interleukin-4 receptor in Streptomyces. Protein Exp Purif 36: 139–145 ( 2004)
Masuda T, Wada K, Nakajima A, Okura M, Kudo C, Kadowaki T, Kogo M, Kamisaki Y . Critical role of peroxisome proliferator-activated receptor γ on anoikis and invasion of squamous cell carcinoma. Clin Cancer Res 11 ( 11): 4012–4021 ( 2005)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, K., Guo, L., Zou, Y. et al. 4849F, a New Metabolite Produced by the Streptomyces sp. 4849 as an Inhibitor of IL-4 Receptor. J Antibiot 60, 325–327 (2007). https://doi.org/10.1038/ja.2007.42
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/ja.2007.42
Keywords
This article is cited by
-
Pharmacological and Predicted Activities of Natural Azo Compounds
Natural Products and Bioprospecting (2017)