Four New Macrocyclic Trichothecenes from Two Strains of Marine-derived Fungi of the Genus Myrothecium

The Journal of Antibiotics volume 59, pages451–455(2006)Cite this article

Abstract

Three new macrocyclic trichothecenes, named 12′-hydroxyroridin E (1), roridin Q (2), and 2′,3′-deoxyroritoxin D (3), were isolated from the marine-derived fungus Myrothecium roridum TUF 98F42, and a new macrocyclic trichothecene, named roridin R (4), was isolated from Myrothecium sp. TUF 02F6 together with roridins A and H and isororidin E. The structures of new compounds were determined on the basis of their spectral data. Compound 2 possessed a unique ether moiety at the 13′ position of 1. Compound 4 was a 2′,3′-dihydro-2′-hydroxy derivative of roridin H. The IC50 values of compounds 1, 2, and 4 against the murine leukemia cell line L1210 were 0.19, 31.2, and 0.45 μM, respectively. Compound 3 showed antiyeast activity to Saccharomyces cerevisiae at 1 μg/disc (inhibition zone: 12.2 mm), which was about 10 time more active than roritoxin D (10.2 mm at 10 μg/disc).

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Author notes

  1. Kazuyo Ukai & Michio Namikoshi

    Present address: Tohoku Pharmaceutical University, Komatsushima, Aoba-ku, Sendai, 981-8558, Japan

Affiliations

  1. Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo, 108-8477, Japan

    Jinzhong Xu, Azusa Takasaki, Kazuyo Ukai, Hiroshi Nagai & Michio Namikoshi

  2. Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0032, Japan

    Hisayoshi Kobayashi

  3. Faculty of Pharmaceutical Sciences, Kyoritsu University of Pharmacy, Minato-ku, Tokyo, 105-8512, Japan

    Taiko Oda & Junko Yamada

  4. Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado, 95115, Indonesia

    Remy E P Mangindaan

Authors
  1. Jinzhong Xu
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  2. Azusa Takasaki
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  3. Hisayoshi Kobayashi
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  4. Taiko Oda
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  5. Junko Yamada
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  6. Remy E P Mangindaan
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  7. Kazuyo Ukai
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  8. Hiroshi Nagai
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  9. Michio Namikoshi
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Correspondence to Michio Namikoshi.

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Xu, J., Takasaki, A., Kobayashi, H. et al. Four New Macrocyclic Trichothecenes from Two Strains of Marine-derived Fungi of the Genus Myrothecium. J Antibiot 59, 451–455 (2006). https://doi.org/10.1038/ja.2006.63

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Keywords

  • Myrothecium roridum
  • marine-derived fungus
  • roridin Q
  • roridin R
  • macrocyclic trichothecene
  • cytotoxicity
  • L1210

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