Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668

Abstract

Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonstrate that lichen-associated fungi potentially are a good resource for new bioactive natural products for current screening programs.

References

  1. Crittenden PD, David JD, Hawksworth DL, Campbell PS . Attempted isolation and success in the culturing of a broad spectrum of lichen-forming and lichenicolous fungi. New Phytol 130: 267–297 ( 1995)

    Article  Google Scholar 

  2. Lawrey J, Diederich P . Lichenicolous fungi: Interaction, evolution, and biodiversity. Bryologist 160: 80–120 ( 2003)

    Article  Google Scholar 

  3. Crittenden PD, Porter N . Lichen-forming fungi: Potential sources of novel metabolites. Trends Biotechnol 9: 409–414 ( 1991)

    CAS  Article  Google Scholar 

  4. Seephonkai P, Isaka M, Kittakoop P, Palittapongarnpim P, Kamchonwongpaisan S, Tanticharoen M, Thebtaranonth Y . Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050. Planta Medica 68: 45–48 ( 2002)

    CAS  Article  Google Scholar 

  5. Takenaka Y, Tanahashi T, Nagakura N, Itoh A, Hamada N . Three isocoumarins and a benzofuran from the cultured lichen mycobionts of Pyrenula sp. Phytochemistry 65: 3119–3123 ( 2004)

    CAS  Article  Google Scholar 

  6. Lilly VG, Barnett HL . Physiology of Fungi. McGraw-Hill, New York ( 1951)

    Google Scholar 

  7. Kornerup A, Wanscher JH . Methuen Handbook of Colour, 3rd ed. Eyre Methuen Co., London ( 1978)

    Google Scholar 

  8. Yada H, Sato H, Toshima H, Deura M, Ichihara A . (−)-Semivioxanthin, a new abscisic active compound against Hinoki cypress leaves isolated from Cryptosporiopsis abietina. Biosci Biotechnol Biochem 65: 484–486 ( 2001)

    CAS  Article  Google Scholar 

  9. Drochner D, Muller M . Total synthesis of (R)- and (S)-semi-vioxanthin. Eur J Org Chem 1: 211–215 ( 2001)

    Article  Google Scholar 

  10. Scudamore KA, Clarke JH, Hetmanski MT . Isolation of Penicillium strains producing ochratoxin A, citrinin, xanthomegnin, viomellein and vioxanthin from stored cereal grains. Lett Appl Microbiol 17: 82–87 ( 1993)

    CAS  Article  Google Scholar 

  11. Suzuki K, Nozawa K, Nakajima S, Kawai K . Structure revision of mycotoxin, viriditoxin, and its derivatives. Chem Pharm Bull 38: 3180–3181 ( 1990)

    CAS  Article  Google Scholar 

  12. Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, Gonzalez A, Cully D, Bramhill D, Singh S . Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. J Biol Chem 278: 44424–44428 ( 2003)

    CAS  Article  Google Scholar 

  13. Singh PD, Johnson JH, Aklonis CA, Bush K, Fisher SM, O'Sullivan J . Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties. J Antibiot 38: 706–712 ( 1985)

    CAS  Article  Google Scholar 

  14. NCCLS. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standards: M7A5, Vol. 19. National Committee for Clinical Laboratory Standards, Villanova ( 2000)

  15. Elix JA, Wardlaw JH . Pigmentosin A, a new naphthopyrone from the lichen Hypotrachyna immaculata. Australian J Chem 57: 681–683 ( 2004)

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Haiyin He.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

He, H., Bigelis, R., Yang, H. et al. Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668. J Antibiot 58, 731–736 (2005). https://doi.org/10.1038/ja.2005.99

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ja.2005.99

Keywords

  • lichenicolous
  • fungus
  • bisnaphthopyrone
  • lichenicolins
  • antibacterial

Further reading

Search

Quick links