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Circumdatin H, a New Inhibitor of Mitochondrial NADH Oxidase, from Aspergillus ochraceus

The Journal of Antibiotics volume 58, pages 416–419 (2005)Cite this article

Abstract

Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.

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Affiliations

  1. Centro de Ecología Química Agrícola, Universidad Politécnica de Valencia, Campus de Vera, Edificio 9B, Laboratorio 111, Valencia, 46022, Spain

    M Pilar López-Gresa, M Carmen González, Jaime Primo & Pilar Moya

  2. Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia, Universitat de València, Avgda Vicent Andrés Estellés s/n, Burjassot (València), 46100, Spain

    Vanessa Romero & Ernesto Estornell

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  1. M Pilar López-Gresa
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  2. M Carmen González
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  3. Jaime Primo
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  4. Pilar Moya
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  5. Vanessa Romero
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  6. Ernesto Estornell
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Correspondence to M Pilar López-Gresa.

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López-Gresa, M., González, M., Primo, J. et al. Circumdatin H, a New Inhibitor of Mitochondrial NADH Oxidase, from Aspergillus ochraceus. J Antibiot 58, 416–419 (2005). https://doi.org/10.1038/ja.2005.54

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  • DOI: https://doi.org/10.1038/ja.2005.54

Keywords

  • Aspergillus ochraceus
  • alkaloids
  • benzodiazepine
  • circumdatin
  • flavacol
  • stephacidin A
  • mitochondrial respiratory chain inhibitors

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