Abstract
A new microbial metabolite Sch 725424 (1) was isolated from the culture of Kitasatospora sp. The structure elucidation of 1 was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (2). Compound 1 showed inhibitory activity against Staphylococcus aureus with MIC values 1∼2 µg/ml, and also displayed weak antifungal activity against Saccharomyces cerevisiae (PM503) with an MIC 32 µg/ml.
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Yang, SW., Chan, TM., Terracciano, J. et al. New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp.. J Antibiot 58, 192–195 (2005). https://doi.org/10.1038/ja.2005.22
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DOI: https://doi.org/10.1038/ja.2005.22
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