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Targeting the gut to treat obesity and its metabolic consequences: view from the Chair

International Journal of Obesity Supplements volume 6, pages S3–S5 (2016)Cite this article

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Abstract

The neurohumoral signaling systems of the gastrointestinal (GI) tract are considered the most significant of the peripheral inputs controlling both food intake in the short term and energy balance over a longer time course. The importance of the GI tract in the control of energy balance is underscored by the marked beneficial effects of bariatric surgeries for the treatment of obesity. Despite their effectiveness, the mechanisms of bariatric surgery remain to be fully elucidated. Considerable new evidence points to the importance of gut–brain communication, gut barrier function and microbial signaling as three of the most important mechanisms of bariatric surgery-induced weight loss. These mechanisms are reviewed in the present article and the accompanying four papers.

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Acknowledgements

Publication of this article was sponsored by the Université Laval’s Research Chair in Obesity in an effort to inform the public on the causes, consequences, treatments and prevention of obesity. KAS is the Crohn’s Colitis Canada Chair in IBD Research at University of Calgary.

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Authors and Affiliations

  1. Department of Physiology & Pharmacology, Hotchkiss Brain Institute and Snyder Institute of Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

    K A Sharkey

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  1. K A Sharkey
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Correspondence to K A Sharkey.

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Sharkey, K. Targeting the gut to treat obesity and its metabolic consequences: view from the Chair. Int J Obes Supp 6 (Suppl 1), S3–S5 (2016). https://doi.org/10.1038/ijosup.2016.2

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