To evaluate the effect of single or dual field irradiation (IR) with the same dose on damage to miniature pig parotid glands.
Sixteen miniature pigs were divided into two IR groups (n=6) and a control group (n=4). The irradiation groups were subjected to 20 Gy X‐radiation to one parotid gland using single‐field or dual‐field modality by linear accelerator. The dose‐volume distributions between two IR groups were compared. Saliva from parotid glands and blood were collected at 0, 4, 8 and 16 weeks after irradiation. Parotid glands were removed at 16 weeks to evaluate tissue morphology.
The irradiation dose volume distributions were significantly different between single and dual field irradiation groups (t=4.177, P=0.002), although dose volume histogramin (DVH) indicated the equal maximal dose in parotid glands. Saliva flow rates from IR side decreased dramatically at all time points in IR groups, especially in dual field irradiation group. The radiation caused changes of white blood cell count in blood, lactate dehydrogenase and amylase in serum, calcium, potassium and amylase in saliva. Morphologically, more severe radiation damage was found in irradiated parotid glands from dual field irradiation group than that from single field irradiation group.
Data from this large animal model demonstrated that the radiation damage from the dual field irradiation was more severe than that of the single field irradiation at the same dose, suggesting that dose‐volume distribution is an important factor in evaluation of the radiobiology of parotid glands.
About this article
Cite this article
Yan, X., Hai, B., Shan, Z. et al. Effect of Same‐dose Single or Dual Field Irradiation on Damage to Miniature Pig Parotid Glands. Int J Oral Sci 1, 16–25 (2009) doi:10.4248/ijos.08001
- irradiation damage
- miniature pig
- parotid gland
Intraglandular Transplantation of Adipose-Derived Stem Cells for the Alleviation of Irradiation-Induced Parotid Gland Damage in Miniature Pigs
Journal of Oral and Maxillofacial Surgery (2017)
Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors
Radiation Research (2016)
Improvement in the repair of defects in maxillofacial soft tissue in irradiated minipigs by a mixture of adipose-derived stem cells and platelet-rich fibrin
British Journal of Oral and Maxillofacial Surgery (2014)
Radioprotective Effect ofOcimum sanctumand Amifostine on the Salivary Gland of Rats After Therapeutic Radioiodine Exposure
Cancer Biotherapy & Radiopharmaceuticals (2011)