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Myeloperoxidase-positive cell infiltration of normal colorectal mucosa is related to body fatness and is predictive of adenoma occurrence

International Journal of Obesity volume 41, pages 982–985 (2017)Cite this article

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Abstract

Body fatness is a risk factor for colorectal cancer, and promotes an inflammatory environment. Indeed, inflammation in normal colorectal mucosa may be a factor linking body fatness to colorectal carcinogenesis. In this study, we evaluated myeloperoxidase (MPO)-positive cells infiltration of normal colorectal mucosa as a marker of cancer-promoting inflammation in overweight and obese subjects. One hundred and three subjects with normal colonoscopy entered the study. Waist circumference (WC) and body mass index (BMI) were measured, and MPO-positive cells on histological sections of biopsies of normal colorectal mucosa were counted under a light microscope. The occurrence of adenomas was then evaluated on follow-up colonoscopies. Mean MPO-positive cell count (±s.e.m.) was higher in subject with a WC equal or above the obesity cutoff values according to gender (2.63±0.20 vs 2.06±0.18, P=0.03), and in subjects with BMI equal or above 25 kg m−2 (2.54±0.18 vs 1.97±0.20, P=0.03). A Cox proportional hazard model showed that mean MPO-positive cell count in normal colorectal mucosa was the only factor independently related to occurrence of adenomas in follow-up colonoscopies. Though preliminary, these results show that MPO-positive cell infiltration in normal colorectal mucosa is related with body fatness, as evaluated by WC and BMI, and it may be considered a useful and simple marker to estimate adenoma occurrence risk.

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References

  1. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008; 359: 2105–2120.

    Article  CAS  Google Scholar 

  2. World Cancer Research Fund/American Institute for Cancer Research. Continuous Update Project Report. Food, Nutrition, Physical Activity, and the Prevention of Colorectal Cancer, 2011..

  3. Campbell PT, Jacobs ET, Ulrich CM, Figueiredo JC, Poynter JN, McLaughlin JR et al. Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst 2010; 102: 391–400.

    Article  Google Scholar 

  4. Alemán JO, Eusebi LH, Ricciardiello L, Patidar K, Sanyal AJ, Holt PR . Mechanisms of obesity-induced gastrointestinal neoplasia. Gastroenterology 2014; 146: 357–373.

    Article  Google Scholar 

  5. Bruce WR, Giacca A, Medline A . Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 2000; 9: 1271–1279.

    CAS  PubMed  Google Scholar 

  6. Lin JH, Giovannucci E . Sex hormones and colorectal cancer: what have we learned so far? J Natl Cancer Inst 2010; 102: 1746–1747.

    Article  Google Scholar 

  7. Poullis A, Foster R, Shetty A, Fagerhol MK, Mendall MA . Bowel inflammation as measured by fecal calprotectin: a link between lifestyle factors and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2004; 13: 279–284.

    Article  CAS  Google Scholar 

  8. John BJ, Abulafi AM, Poullis A, Mendall MA . Chronic subclinical bowel inflammation may explain increased risk of colorectal cancer in obese people. Gut 2007; 56: 1034–1035.

    Article  Google Scholar 

  9. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S . Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007; 56: 1010–1013.

    Article  CAS  Google Scholar 

  10. Roncucci L, Mora E, Mariani F, Bursi S, Pezzi A, Rossi G et al. Myeloperoxidase-positive cell infiltration in colorectal carcinogenesis as indicator of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2008; 17: 2291–2297.

    Article  CAS  Google Scholar 

  11. Okorodudu DO, Jumean MF, Montori VM, Romero-Corral A, Somers VK, Erwin PJ et al. Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. Int J Obes 2010; 34: 791–799.

    Article  CAS  Google Scholar 

  12. Ben Q, An W, Jiang Y, Zhan X, Du Y, Cai QC et al. Body mass index increases risk for colorectal adenomas based on meta-analysis. Gastroenterology 2012; 142: 762–772.

    Article  Google Scholar 

  13. Lee YJ, Myung SK, Cho B, Park BJ, Park JH, Ju W et al. Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis. Cancer Causes Control 2011; 22: 1021–1035.

    Article  Google Scholar 

  14. Hong S, Cai Q, Chen D, Zhu W, Huang W, Li Z . Abdominal obesity and the risk of colorectal adenoma: a meta-analysis of observational studies. Eur J Cancer Prev 2012; 21: 523–531.

    Article  Google Scholar 

  15. Levine JS, Ahnen DJ . Clinical practice. Adenomatous polyps of the colon. N Engl J Med 2006; 355: 2551–2557.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank the Associazione per la Ricerca sui Tumori Intestinali (ARTI) for the support given to the study.

Author contributions

FM contributed to the conception and design of the study, patient recruitment, collection, analysis and interpretation of the data, drafting of the article and critical revision of the manuscript; VB, AB and AM contributed to patient recruitment and data collection; MP, GR, SM and PS contributed to critical revision of manuscript; PB contributed to statistical analyses; and LR contributed to conception and design of the study, analysis and interpretation of the data, and final approval of the article.

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Authors and Affiliations

  1. Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy

    F Mariani, M Pedroni, G Rossi, S Mancini, P Benatti & L Roncucci

  2. Department of Medicine, Emergency Medicine and Medical Specialties, Endoscopy Unit, Policlinico, Modena, Italy

    V Boarino, A Bertani & A Merighi

  3. Department of Biomedical, Metabolic and Neural Sciences, Section of Human Morphology, University of Modena and Reggio Emilia, Policlinico, Modena, Italy

    P Sena

Authors
  1. F Mariani
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  2. V Boarino
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  3. A Bertani
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  4. A Merighi
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  5. M Pedroni
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  6. G Rossi
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  7. S Mancini
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  8. P Sena
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  9. P Benatti
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  10. L Roncucci
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Corresponding author

Correspondence to F Mariani.

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The authors declare no conflict of interest.

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Supplementary Information accompanies this paper on International Journal of Obesity website

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Mariani, F., Boarino, V., Bertani, A. et al. Myeloperoxidase-positive cell infiltration of normal colorectal mucosa is related to body fatness and is predictive of adenoma occurrence. Int J Obes 41, 982–985 (2017). https://doi.org/10.1038/ijo.2017.80

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  • DOI: https://doi.org/10.1038/ijo.2017.80

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