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A narrative review of obesity and hearing loss

International Journal of Obesity volume 41, pages 1066–1073 (2017)Cite this article

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Abstract

The comorbidities related to obesity are already extensive, but as the prevalence of obesity increases globally, so do the number of its associated conditions. The relationship between hearing impairment and obesity is a relatively recent research interest, but is significant as both conditions have the ability to substantially reduce an individual’s quality of life both physically and psychologically. Obesity has a significant effect on vascular function, and this may have an impact on highly vascular organs such as the auditory system. This review aims to provide an overview of the existing literature surrounding the association between hearing loss and obesity, in order to emphasise these two highly prevalent conditions, and to identify areas of further investigation. Our literature search identified a total of 298 articles with 11 articles of relevance to the review. The existing literature in this area is sparse, with interest ranging from obesity and its links to age-related hearing impairment (ARHI) and sudden sensorineural hearing loss (SSNHL), to animal models and genetic syndromes that incorporate both disorders. A key hypothesis for the underlying mechanism for the relationship between obesity and hearing loss is that of vasoconstriction in the inner ear, whereby strain on the capillary walls due to excess adipose tissue causes damage to the delicate inner ear system. The identified articles in this review have not established a causal relationship between obesity and hearing impairment. Further research is required to examine the emerging association between obesity and hearing impairment, and identify its potential underlying mechanisms.

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References

  1. Organisation WH. Global Health Observatory (GHO) data World Health Organisation website (Available from http://www.who.int/gho/ncd/risk_factors/obesity_text/en/. Accessed on 2015.

  2. Thiebaud N, Johnson MC, Butler JL, Bell GA, Ferguson KL, Fadool AR et al. Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning. J Neurosci 2014; 34: 6970–6984.

    Article  CAS  Google Scholar 

  3. Owens E, Talbott CB, Schubert ED . Vowel discrimination of hearing-impaired listeners. J Speech Hear Res 1968; 11: 648–655.

    Article  CAS  Google Scholar 

  4. Roth TN, Hanebuth D, Probst R . Prevalence of age-related hearing loss in Europe: a review. Eur Arch Oto-rhino-laryngol 2011; 268: 1101–1107.

    Article  Google Scholar 

  5. Loss AoH. Statistics: action on hearing loss (Available from http://www.actiononhearingloss.org.uk/your-hearing/about-deafness-and-hearing-loss/statistics.aspx. Accessed on 2015.

  6. Schum DJ. Providing amplification to the aging auditory system audiology online (Available from http://www.audiologyonline.com/articles/providing-amplification-to-aging-auditory-843. Accessed on 2011.

  7. Tun PA, McCoy S, Wingfield A . Aging, hearing acuity, and the attentional costs of effortful listening. Psychol Aging 2009; 24: 761–766.

    Article  Google Scholar 

  8. Hwang JH, Wu CC, Hsu CJ, Liu TC, Yang WS . Association of central obesity with the severity and audiometric configurations of age-related hearing impairment. Obesity 2009; 17: 1796–1801.

    Article  Google Scholar 

  9. Horikawa C, Kodama S, Tanaka S, Fujihara K, Hirasawa R, Yachi Y et al. Diabetes and risk of hearing impairment in adults: a meta-analysis. J Clin Endocrinol Metab 2013; 98: 51–58.

    Article  CAS  Google Scholar 

  10. Akinpelu OV, Mujica-Mota M, Daniel SJ . Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta-analysis. Laryngoscope 2014; 124: 767–776.

    Article  Google Scholar 

  11. Alberti KGMM, Zimmet P, Shaw J . Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabetic Med 2006; 23: 469–480.

    Article  CAS  Google Scholar 

  12. Stachler RJ, Chandrasekhar SS, Archer SM, Rosenfeld RM, Schwartz SR, Barrs DM et al. Clinical practice guideline: sudden hearing loss. Otolaryngology 2012; 146: S1–35.

    Article  Google Scholar 

  13. Tadros SF, Frisina ST, Mapes F, Kim S, Frisina DR, Frisina RD . Loss of peripheral right-ear advantage in age-related hearing loss. Audiol Neuro-otol 2005; 10: 44–52.

    Article  Google Scholar 

  14. Aimoni C, Bianchini C, Borin M, Ciorba A, Fellin R, Martini A et al. Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: a case-control study. Audio Neuro-otol 2010; 15: 111–115.

    Article  CAS  Google Scholar 

  15. Yavuz E, Morawski K, Telischi FF, Ozdamar O, Delgado RE, Manns F et al. Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits. J Neurosci Methods 2005; 147: 55–64.

    Article  Google Scholar 

  16. Lee JS, Kim DH, Lee HJ, Kim HJ, Koo JW, Choi HG et al. Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing loss. PLoS One 2015; 10: e0122496.

    Article  Google Scholar 

  17. Ballesteros F, Tassies D, Reverter JC, Alobid I, Bernal-Sprekelsen M . Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors. Audiol Neuro-otol 2012; 17: 400–408.

    Article  CAS  Google Scholar 

  18. Hwang JH . Role of obesity on the prognosis of sudden sensorineural hearing loss in adults. Otolaryngology 2015; 153: 251–256.

    Article  Google Scholar 

  19. Organisation WH. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004; 363: 157–163.

    Article  Google Scholar 

  20. Federation ID. Diabetes in Taiwan. (Available from http://www.idf.org/membership/wp/taiwan. Accessed on 2015.

  21. Lalwani AK, Katz K, Liu YH, Kim S, Weitzman M . Obesity is associated with sensorineural hearing loss in adolescents. Laryngoscope 2013; 123: 3178–3184.

    Article  Google Scholar 

  22. Hong JW, Jeon JH, Ku CR, Noh JH, Yoo HJ, Kim DJ . The prevalence and factors associated with hearing impairment in the Korean adults: the 2010-2012 Korea National Health and Nutrition Examination Survey (observational study). Medicine 2015; 94: e611.

    Article  Google Scholar 

  23. Kang SH, Jung da J, Cho KH, Park JW, Yoon KW, Do JY . The association between metabolic syndrome or chronic kidney disease and hearing thresholds in Koreans: the Korean National Health and Nutrition Examination Survey 2009-2012. PLoS One 2015; 10: e0120372.

    Article  Google Scholar 

  24. Health NIo. National cholesterol education program ATP III guidelines at-a-glance quick desk reference (Available from http://www.nhlbi.nih.gov/files/docs/guidelines/atglance.pdf. Accessed on 2001.

  25. Flamme GA, Deiters K, Needham T . Distributions of pure-tone hearing threshold levels among adolescents and adults in the United States by gender, ethnicity, and age: Results from the US National Health and Nutrition Examination Survey. Int J Audiol 2011; 50: S11–S20.

    Article  Google Scholar 

  26. Frisina ST, Mapes F, Kim S, Frisina DR, Frisina RD . Characterization of hearing loss in aged type II diabetics. Hear Res 2006; 211: 103–113.

    Article  Google Scholar 

  27. Soardo G, Donnini D, Domenis L, Catena C, De Silvestri D, Cappello D et al. Oxidative stress is activated by free fatty acids in cultured human hepatocytes. Metab Syndrome Relat Disord 2011; 9: 397–401.

    Article  CAS  Google Scholar 

  28. Bakker SJ, IJzerman RG, Teerlink T, Westerhoff HV, Gans RO, Heine RJ . Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure? Atherosclerosis 2000; 148: 17–21.

    Article  CAS  Google Scholar 

  29. Curhan SG, Eavey R, Wang M, Stampfer MJ, Curhan GC . Body mass index, waist circumference, physical activity, and risk of hearing loss in women. Am J Med 2013; 126: 1142 e1–1142 e8.

    Article  Google Scholar 

  30. Kim TS, Park SW, Kim do Y, Kim EB, Chung JW, So HS . Visceral adipose tissue is significantly associated with hearing thresholds in adult women. Clini Endocrinol 2014; 80: 368–375.

    Article  Google Scholar 

  31. Hwang JH, Hsu CJ, Liu TC, Yang WS . Association of plasma adiponectin levels with hearing thresholds in adults. Clin Endocrinol 2011; 75: 614–620.

    Article  CAS  Google Scholar 

  32. Wu CC, Tsai CH, Lu YC, Lin HC, Hwang JH, Lin YH et al. Contribution of adiponectin and its type 1 receptor to age-related hearing impairment. Neurobiol Aging 2015; 36: 2085–2093.

    Article  CAS  Google Scholar 

  33. Fransen E, Van Laer L, Lemkens N, Caethoven G, Flothmann K, Govaerts P et al. A novel Z-score-based method to analyze candidate genes for age-related hearing impairment. Ear Hearing 2004; 25: 133–141.

    Article  Google Scholar 

  34. Barrenas ML, Jonsson B, Tuvemo T, Hellstrom PA, Lundgren M . High risk of sensorineural hearing loss in men born small for gestational age with and without obesity or height catch-up growth: a prospective longitudinal register study on birth size in 245000 Swedish conscripts. J Clin Endocrinol Metabol 2005; 90: 4452–4456.

    Article  Google Scholar 

  35. Hales CN, Barker DJ . The thrifty phenotype hypothesis. Br Med Bull 2001; 60: 5–20.

    Article  CAS  Google Scholar 

  36. Morgan T . Turner syndrome: diagnosis and management. Am Fam Phys 2007; 76: 405–410.

    Google Scholar 

  37. Alstrom CH, Hallgren B, Nilsson LB, Asander H . Retinal degeneration combined with obesity, diabetes mellitus and neurogenous deafness: a specific syndrome (not hitherto described) distinct from the Laurence-Moon-Bardet-Biedl syndrome: a clinical, endocrinological and genetic examination based on a large pedigree. Acta Psychiatr Neurol Scand Suppl 1959; 129: 1–35.

    CAS  PubMed  Google Scholar 

  38. Marshall JD, Maffei P, Collin GB, Naggert JK . Alström syndrome: genetics and clinical overview. Curr Genomics 2011; 12: 225–235.

    Article  CAS  Google Scholar 

  39. Tsigos C, Kyrou I, Raptis SA . Monogenic forms of obesity and diabetes mellitus. J Pediatr Endocrinol Metab 2002; 15: 241–253.

    Article  Google Scholar 

  40. Emes RD, Goodstadt L, Winter EE, Ponting CP . Comparison of the genomes of human and mouse lays the foundation of genome zoology. Hum Mol Genet 2003; 12: 701–709.

    Article  CAS  Google Scholar 

  41. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002; 420: 520–562.

    Article  CAS  Google Scholar 

  42. Hwang JH, Hsu CJ, Yu WH, Liu TC, Yang WS . Diet-induced obesity exacerbates auditory degeneration via hypoxia, inflammation, and apoptosis signaling pathways in CD/1 mice. PLoS One 2013; 8: e60730.

    Article  CAS  Google Scholar 

  43. Riva C, Donadieu E, Magnan J, Lavieille JP . Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea. Exp Gerontol 2007; 42: 327–336.

    Article  CAS  Google Scholar 

  44. Vasilyeva ON, Frisina ST, Zhu X, Walton JP, Frisina RD . Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis. Hear Res 2009; 249: 44–53.

    Article  Google Scholar 

  45. McQueen CT, Baxter A, Smith TL, Raynor E, Yoon SM, Prazma J et al. Non-insulin-dependent diabetic microangiopathy in the inner ear. J Laryngol Otol 1999; 113: 13–18.

    CAS  PubMed  Google Scholar 

  46. Triana RJ, Suits GW, Garrison S, Prazma J, Brechtelsbauer PB, Michaelis OE et al. Inner ear damage secondary to diabetes mellitus. I. Changes in adolescent SHR/N-cp rats. Arch Otolaryngol 1991; 117: 635–640.

    Article  CAS  Google Scholar 

  47. Ahima RS . Adipose tissue as an endocrine organ. Obesity 2006; 14: 242s–249s.

    Article  CAS  Google Scholar 

  48. Ouchi N, Parker JL, Lugus JJ, Walsh K . Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011; 11: 85–97.

    Article  CAS  Google Scholar 

  49. Fukushima H, Cureoglu S, Schachern PA, Paparella MM, Harada T, Oktay MF . EFfects of type 2 diabetes mellitus on cochlear structure in humans. Arch Otolaryngol 2006; 132: 934–938.

    Article  Google Scholar 

  50. Diseases NIoDaDaK. Diabetic neuropathies: the nerve damage of diabetes (Available from http://www.niddk.nih.gov/health-information/health-topics/Diabetes/diabetic-neuropathies-nerve-damage-diabetes/Pages/diabetic-neuropathies-nerve-damage.aspx). Accessed on 2015.

  51. Alateeq BAM, Alturki A, Amin S . Assessment of the amino acids profiles linked to hearing loss among saudi students at the University of Hail, Kingdom of Saudi Arabia. Int J Clin Nutr 2014; 2: 18–26.

    Google Scholar 

  52. Sha SH, Schacht J . Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hear Res 2000; 142: 34–40.

    Article  CAS  Google Scholar 

  53. Yildiz O, Ozata M, Ozkardes A, Corakci A, Gundogan N, Gundogan MA . L-carnitine treatment improves brain stem auditory evoked potentials in diabetic rats. Neuroreport 1996; 7: 2957–2959.

    Article  CAS  Google Scholar 

  54. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005; 366: 662–664.

    Article  CAS  Google Scholar 

  55. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752–1761.

    Article  CAS  Google Scholar 

  56. Rani V, Deep G, Singh RK, Palle K, Yadav UC . Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sci 2016; 148: 183–193.

    Article  CAS  Google Scholar 

  57. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752–1761.

    Article  CAS  Google Scholar 

  58. Kitahara CM, Flint AJ, Berrington de Gonzalez A, Bernstein L, Brotzman M, MacInnis RJ et al. Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies. PLoS Med 2014; 11: e1001673.

    Article  Google Scholar 

  59. Evans MB, Tonini R, Shope CD, Oghalai JS, Jerger JF, Insull W Jr et al. Dyslipidemia and auditory function. Otol Neurotol 2006; 27: 609–614.

    Article  Google Scholar 

  60. Melse-Boonstra A, Mackenzie I . Iodine deficiency, thyroid function and hearing deficit: a review. Nutr Res Rev 2013; 26: 110–117.

    Article  CAS  Google Scholar 

  61. Magge SN, Stettler N, Koren D, Levitt Katz LE, Gallagher PR, Mohler ER 3rd et al. Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents. J Clin Endocrinol Metab 2011; 96: 1549–1554.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinical Research Core, Weill Cornell Medicine—Qatar, Education City, Qatar Foundation, Doha, Qatar

    N Dhanda & S Taheri

  2. Department of Medicine, Weill Cornell Medicine, New York, NY, USA

    S Taheri

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Correspondence to S Taheri.

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Dhanda, N., Taheri, S. A narrative review of obesity and hearing loss. Int J Obes 41, 1066–1073 (2017). https://doi.org/10.1038/ijo.2017.32

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