Bariatric surgery is currently the most effective therapy for type 2 diabetes. However, the mechanisms underlying its beneficial effects remain elusive. Here we studied the effects of bariatric surgery on circulating meteorin-like (Metrnl) and oncostatin m (OSM) levels, two hormones intimately linked to energy homeostasis. Metrnl and OSM levels were assessed at baseline, 6 and 12 months after laparoscopic sleeve gastrectomy (LSG) in 25 patients with obesity, as well as in 33 normal-weight controls. At baseline, patients with obesity showed lower Metrnl and higher OSM levels compared to controls. LSG increased Metrnl and decreased OSM levels, in correlation to improvements in glucose and lipid homeostasis. Our data indicate that LSG conversely modulated Metrnl and OSM levels, and suggest that a dual approach modulating these two molecules might provide a novel strategy for obesity and type 2 diabetes treatment.
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Samples from patients included in this study were provided by the IGTP HUGTP Biobank integrated in the Spanish National Biobanks Network of Instituto de Salud Carlos III (PT13/0010/0009) and they were processed following standard operating procedures with the appropriate approval of the Ethical and Scientific Committees. DS-I is an Investigator of the Miguel Servet Fund from Carlos III National Institute of Health, Spain. AP is a Ramón y Cajal researcher. This study was supported by Instituto de Salud Carlos III, and by the Fondo Europeo de Desarrollo Regional (FEDER), Madrid, Spain (CP15/00106), and by SAF2014-55702-JIN from the Ministerio de Ciencia e Innovación, Spain, co-financed by the European Regional Development Fund (ERDF).
The authors declare no conflict of interest.
Supplementary Information accompanies this paper on International Journal of Obesity website
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Journal of Cellular and Molecular Medicine (2019)