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Clinical Studies and Practice

Serum oxLDL–β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese

International Journal of Obesity volume 42, pages 405–411 (2018)Cite this article

Subjects

Abstract

Background/Objectives:

OxLDL–β2GPI complex has been suggested to have a role in the development of atherosclerosis and other inflammatory diseases. The aim of this study was to investigate the possible association of circulating oxLDL–β2GPI with obesity-induced inflammatory state of adipose tissue and related comorbidities as metabolic syndrome development.

Subjects/Methods:

Two cohorts of subjects were examined in the study. Cohort I: 36 women with wide range of body mass index (17–48 kg m−2) and metabolic status (with or without metabolic syndrome (MS); cohort II: 20 obese women undergoing a dietary intervention (DI) consisting of 1-month very-low-calorie diet, and 5 months of weight-stabilization period. Serum levels of oxLDL–β2GPI were measured by enzyme-linked immunosorbent assay. Insulin sensitivity was evaluated by hyperinsulinemic-euglycemic clamp and homeostasis model assessment of insulin resistance. mRNA expression of macrophage markers was determined in both subcutaneous (SAT) and visceral (VAT) adipose tissue in cohort I and in SAT in cohort II.

Results:

Serum oxLDL–β2GPI levels were increased in obese subjects with MS compared to lean or obese without MS (obese with MS: 26.6±5.0 vs lean: 15.17±1.97, P<0.001; vs obese without MS: 16.36±2.89, P<0.05). Serum oxLDL–β2GPI correlated with MS indices (glucose, high-density lipoprotein, triglyceride and ureic acid) and with mRNA expression of macrophage markers in VAT. Weight-reducing DI decreased serum oxLDL–β2GPI levels together with lipid parameters and the mRNA expression of inflammatory markers in SAT.

Conclusions:

OxLDL–β2GPI seems to be an important marker of visceral adipose tissue inflammation and possibly a factor contributing to insulin resistance and metabolic syndrome development in obese patients.

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Acknowledgements

The work was supported by grant 16-14048S from the Grant Agency of Czech Republic, and by Projects PRVOUK P31 and UNCE 20431 from Charles University in Prague.

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Author notes

  1. Second Department of Internal Medicine, University Hospital Kralovske Vinohrady, Prague, Czech Republic

Authors and Affiliations

  1. Department for the Study of Obesity and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic

    M Siklova, M Koc & L Rossmeislová

  2. Franco-Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, and Institut des Maladies Métaboliques et Cardiovasculaires, Université Toulouse III Paul Sabatier, Toulouse, France

    M Siklova, M Koc, L Rossmeislová & P Kraml

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Correspondence to M Siklova.

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Siklova, M., Koc, M., Rossmeislová, L. et al. Serum oxLDL–β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese. Int J Obes 42, 405–411 (2018). https://doi.org/10.1038/ijo.2017.260

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