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BAT is independently affected by peripheral and central pathways

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  1. Pino MF, Divoux A, Simmonds AV, Smith SR, Sparks LM . Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue. Int J Obes 2017; e-pub ahead of print 4 July 2017; doi:10.1038/ijo.2017.155.

    CAS  Article  Google Scholar 

  2. Sellayah D, Bharaj P, Sikder D . Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab 2011; 14: 478–490.

    CAS  Article  Google Scholar 

  3. Sellayah D, Sikder D . Orexin restores aging-related brown adipose tissue dysfunction in male mice. Endocrinology 2014; 155: 485–501.

    Article  Google Scholar 

  4. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ . The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 2002; 110: 515–526.

    CAS  Article  Google Scholar 

  5. Berthoud HR, Patterson LM, Sutton GM, Morrison C, Zheng H . Orexin inputs to caudal raphe neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem Cell Biol 2005; 123: 147–156.

    CAS  Article  Google Scholar 

  6. Tupone D, Madden CJ, Cano G, Morrison SF . An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis. J Neurosci 2011; 31: 15944–15955.

    CAS  Article  Google Scholar 

  7. Kukkonen JP . Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol 2013; 301: C2–C32.

    Article  Google Scholar 

  8. Morrison SF, Madden CJ, Tupone D . Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab 2014; 19: 741–756.

    CAS  Article  Google Scholar 

  9. Leonard CS, Kukkonen JP . Orexin/hypocretin receptor signalling: a functional perspective. Br J Pharmacol 2014; 171: 294–313.

    CAS  Article  Google Scholar 

  10. Nishino S Hypocretin Measurements in the CSF, and Blood and Brain Tissue. Basic and Clinical Applications. In: Nishino S, Sakurai T (eds). Contemporary Clinical Neuroscience: The Orexin/Hypocretin System: Physiology and Pathophysiology. Humana Press Inc.: Totowa, NJ, USA, 2005, pp 73–82.

    Google Scholar 

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Correspondence to J P Kukkonen.

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Kukkonen, J. BAT is independently affected by peripheral and central pathways. Int J Obes 42, 584 (2018).

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