Original Article | Published:

Pediatrics

Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents

International Journal of Obesity volume 41, pages 789792 (2017) | Download Citation

Abstract

Objectives:

Our aim was to investigate the association between the triglycerides/glucose index (TyG index) and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) in the prediction of insulin resistance (IR) among adolescents.

Methods:

We conducted a cross-sectional study among 221 Korean adolescents (168 males and 53 females aged 9–13 years) from May to June 2014 in Chung-ju city. The TyG index was calculated as ln [triglycerides (mg dl−1) × fasting glucose (mg dl−1)/2]. IR was defined using HOMA-IR >95th percentile for age and sex.

Results:

In the IR group, weight, body mass index (BMI), waist circumference, body fat, fasting insulin, fasting plasma glucose, triglyceride levels and triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) were significantly higher than that in the non-IR group. The TG index was significantly different between the IR group (n=22) and non-IR group (n=199), at 8.43±0.45 and 8.05±0.41, respectively (P<0.001). The TyG index was well correlated with HOMA-IR (r=0.41; P<0.001) and showed a strong positive association with TG/HDL-C (r=0.84; P<0.001). The cut-off of the TyG index for diagnosis of insulin resistance was 8.18.

Conclusions:

The TyG index is a simple, cost-effective surrogate marker of insulin resistance among adolescents compared with HOMA-IR.

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Acknowledgements

This research was supported by the Social Problem Solving Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science, Information Communication Technology (ICT) and Future Planning (2013M3C8A2A02078508).

Author information

Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    • B Kang
    • , Y Yang
    • , E Y Lee
    • , H K Yang
    • , H-S Kim
    •  & K-H Yoon
  2. Institute of Catholic Ubiquitous Health Care, The Catholic University of Korea, Seoul, Korea

    • H-S Kim
    • , S-Y Lim
    • , J-H Lee
    •  & K-H Yoon
  3. Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    • S-S Lee
  4. Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

    • B-K Suh

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Competing interests

The authors declare no conflict of interest.

Corresponding authors

Correspondence to J-H Lee or K-H Yoon.

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DOI

https://doi.org/10.1038/ijo.2017.14