Rippe JM, Angelopoulos TJ. Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know? Adv Nutr 2013; 4: 236–245.
Rippe J. The metabolic and endocrine response and health implications of consuming sweetened beverages: findings from recent, randomized, controlled trials. Adv Nutr 2013; 4: 677–686.
Kahn R, Sievenpiper JL. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes? We have, but the pox on sugar is overwrought and overworked. Diabetes Care 2014; 37: 957–962.
Bray GA, Popkin BM. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes? Health Be Damned! Pour on the Sugar. Diabetes Care 2014; 37: 950–956.
Klurfeld DM, Foreyt J, Angelopoulos TJ, Rippe JM. Lack of evidence for high fructose corn syrup as the cause of the obesity epidemic. Int J Obes (Lond) 2012; 27: 771–773.
Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004; 79: 537–543.
Lustig RH. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc 2010; 110: 1307–1321.
Lustig RH, Schmidt LA, Brindis CD. Public health: the toxic truth about sugar. Nature 2012; 482: 27–29.
Bray G. Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard. J Diabetes Sci Technol 2010; 4: 1003–1007.
Rippe JM. The health implications of sucrose, high-fructose corn syrup, and fructose: what do we really know? J Diabetes Sci Technol 4: 1008–10112010.
Sievenpiper JL, de Souza RJ, Kendall CW, Jenkins DJ. Is fructose a story of mice but not men? J Am Diet Assoc 2011; 111: 219–220, author reply 220–212.
van Buul V, Tappy L, Brouns F. Misconceptions about fructose-containing sugars and their role in the obesity epidemic. Nutr Res Rev 2014; 27: 199–130.
White J. Straight talk about high-fructose corn syrup. What it is and what it ain't. Am J Clin Nutr 2008; 88: 1716S–1721S.
White JS. Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism. Adv Nutr 2013; 4: 246–256.
Rippe JM, Angelopoulos TJ. Sugars and Health Controversies. What does the Science Say? Adv Nutr 2015; 6 (Suppl): 493S–503S.
Ha V, Cozma AI, Choo VLW, Mejia SB, de Souza RJ, Sievenpiper JL. Do fructose-containing sugars lead to adverse health consequences? Results of recent systematic reviews and meta-analyses. Adv Nutri 2015; 6: 504S–511S.
Angelopoulos TJ, Lowndes J, Sinnett S, Rippe JM. Fructose containing sugars do not raise blood pressure or uric acid at normal levels of human consumption. J Clin Hypertens 2014; 17: 87–94.
Basu S, Yoffe P, Hills N, Lustig RH. The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. PLoS One 2013; 8: e57873.
Goran MI, Ulijaszek SJ, Ventura EE. High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 2013; 8: 55–64.
Te Morenga LA, Howatson AJ, Jones RM, Mann J. Dietary sugars and cardiometabolic risk: Systematic review and meta-analyses of randomized controlled trials of the effects on blood pressure and lipids. Am J Clinic Nutr 2014; 100: 65–79.
Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2015. US Department of Agriculture, Center for Nutrition Policy and Promotion, Washington, DC, USA.
Stanhope K, Havel P. Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose or high-fructose corn syrup. Am J Clin Nutr 2008; 88: 1733S–1737S.
Teff KL, Grudziak J, Townsend RR, Dunn TN, Grant RW, Adams SH. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 2009; 94: 1562–1559.
Stanhope K, Griffen S, Keim N, Ai M, Otokozawa S, Nakajimak SE et al. Consumption of fructose-, but not glucose sweetened beverages produces an atherogenic lipid profile in overweight/obese men and women. Diabetes 2007; 56 (Suppl 1): A16.
Havel P. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005; 63: 133–157.
Johnson RK, Appel LJ, Brands M, Howard BV, Lefevre M, Lustig RH et al. Dietary sugars intake and cardiovascular health, a scientific statement from the American Heart Association. Circulation 2009; 120: 1011–1020.
Scientific Advisory Committee on Nutrition. Draft Carbohydrates and Health Report, 2014. Available from http://www.sacn.gov.uk/.
World Health OrganizationThe Global Burden of Disease: 2004 Update. World Health Organization: Geneva, Switzerland, 2008.
Institute of MedicineDietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Institute of Medicine of the National Academies. National Academies Press: Washington, DC, USA, 2005.
Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010. US Department of Agriculture, Center for Nutrition Policy and Promotion, Washington, DC, USA.
White JS. Sucrose, HFCS, and fructose: history, manufacture, composition, applications, and production. In: Rippe JM (ed). Fructose, High Fructose Corn Syrup, Sucrose and Health. Springer Publishing: New York, NY, USA, 2014.
Tappy L, Le KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 2010; 90: 23–46.
Sun SZ, Empie MW. Fructose metabolism in humans: what isotopic tracer studies tell us. Nutr Metab 2012; 9: 89.
Hellerstein MK, Schwarz JM, Neese RA. Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr 1996; 16: 523–557.
USDA-ERS. Food Availability (Per capita) Data System: Loss-adjusted food availability [Internet]. Sugar and sweeteners (added), sugar.xls, updated 4 December 2014 [cited 10 March 2015]. Available from http://www.ers.usda.gov/data-products/food-availability-(per-capita)-data-system/.aspx.
Welsh JA, Sharma AJ, Grellinger L, Vos MB. Consumption of added sugars is decreasing in the United States. Am J Clin Nutr 2011; 94: 726–734.
Yudkin J. Pure, White and Deadly. Penguin Books: New York, NY, USA, 1972.
Keys A. Seven Countries. A Multivariate Analysis of Death and Coronary Heart Disease. Harvard University Press: Cambridge, MA, USA, 1980; 1–381.
Melanson KJ, Summers A, Nguyen V, Brosnahan J, Lowndes J, Angelopoulos TJ et al. Body composition, dietary composition, and components of metabolic syndrome in overweight and obese adults after a 12-week trial on dietary treatments focused on portion control, energy density, or glycemic index. Nutr J 2012; 11: 57.
Melanson K, Zuckley L, Lowndes J, Nguyen V, Angelopoulos T, Rippe J. Effects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition 2007; 23: 103–112.
Yu Z, Lowndes J, Rippe J. High-fructose corn syrup and sucrose have equivalent effects on energy-regulating hormones at normal human consumption levels. Nutr Res 2013; 33: 1043–1052.
Soenen S, Westerterp-Plantenga MS. No differences in satiety or energy intake after high fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr 2007; 86: 1586–1594.
Lowndes J, Sinnett S, Pardo S, Nguyen V, Melanson K, Yu Z et al. The effect of normally consumed amounts of sucrose or high fructose corn syrup on body composition and related parameters in overweight/obese subjects. Nutrients 2014; 6: 1128–114.
Kaiser KA, Shikany JM, Keating KD, Allison DB. Will reducing sugar-sweetened beverage consumption reduce obesity? Evidence supporting conjecture is strong, but evidence when testing effect is weak. Obes Rev 2013; 14: 620–633.
Te Morenga L, Mallard S, Mann J. Dietary sugars and body weight: systematic review and meta-analysis of randomized controlled trials and cohort studies. BMJ 2013; 346: e7492.
Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutri 2013; 98: 1084–1102.
Tappy L, Lê K-A. Health effects of fructose and fructose-containing caloric sweeteners: where do we stand 10 years after the initial whistle blowings? Curr Diab Rep 2015; 15: 1–12.
Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010; 303: 235–241.
Cozma A, Ha V, de Souza RJ, Sievenpiper J. Sweeteners and diabetes. In: Rippe J (ed). Fructose, High Fructose Corn Syrup, Sucrose and Health. Springer Publishing: New York, NY, USA, 2014.
Barclay AW, Brand-Miller J. The Australian Paradox: a substantial decline in sugars intake over the same timeframe that overweight and obesity have increased [published erratum appears in Nutrients 2014; 6: 663–664]. Nutrients 2011; 3: 491–504.
Hall KD, Heymsfield SB, Kemnitz JW, Klein S, Schoeller D, Speakman J. Energy balance and its components: implications for body weight regulation. Am J Clin Nutri 2012; 95: 989–994.
International Diabetes Federation, IDF Diabetes Atlas. Epidemiology and Morbidity, 2015. International Diabetes Federation Available from www.idf.org.
Malik VS, Popkin BM, Bray GA, Despres JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 2010; 33: 2477–2483.
Janket SJ, Manson JE, Sesso H, Buring JE, Liu S. A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 2003; 26: 1008–1015.
Hodge AM, English DR, O'Dea K, Giles DD. Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care 2004; 27: 2701–2706.
Colditz GA, Manson JE, Stampfer MJ, Rosner B, Willett WC, Speizer FE. Diet and risk of clinical diabetes in women. Am J Clin Nutri 1992; 55: 1018–1023.
Lowndes J, Sinnett S, Fullerton Z, Angelopoulos T, Rippe J. The effects of fructose containing sugars on weight, body composition and cardiometabolic risk factors when consumed at up to the 90th percentile population consumption level for fructose. Nutrients 2014; 6: 3153–3168.
Lowndes J, Rippe JM, Sinnett S. No change in oral glucose tolerance tests as a result of ten weeks of consumption of various fructose containing sugars or glucose. Diabetes: Clinical Physiology and Treatment SUN-1018-SUN-1018. The Endocrine Society 2014. Available from https://endo.confex.com/endo/2014endo/webprogram/Paper12047.html.
Lowndes J, Sinnett S, Rippe JM. No effect of added sugar consumed at median american intake level on glucose tolerance or insulin resistance. Nutrients 2015; 7: 8830–8845.
Bravo S, Lowndes J, Sinnett S, Yu Z, Rippe J. Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles. Appl Physiol Nutr Metab 2013; 38: 681–688.
Rippe JM, Angelopoulos TJ. Fructose containing sugars and cardiovascular disease. Adv Nutr 2015; 6: 430–439.
Aeberli I, Gerber PA, Hochuli M, Kohler S, Haile SR, Gouni-Berthold I et al. Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial. Am J Clin Nutr 2011; 94: 479–485.
Antar MA, Little JA, Lucas C, Buckley GC, Csima A. Interrelationship between the kinds of dietary carbohydrate and fat in hyperlipoproteinemic patients. 3. Synergistic effect of sucrose and animal fat on serum lipids. Atherosclerosis 1970; 11: 191–201.
Bantle JP, Swanson JE, Thomas W, Laine DC. Metabolic effects of dietary sucrose in type 2 diabetic subjects. Diabetes Care 1993; 16: 1301–1305.
Black RN, Spence M, McMahon RO, Cuskelly GJ, Ennis CN, McCance DR et al. Effect of eucaloric high- and low-sucrose diets with identical macronutrient profile on insulin resistance and vascular risk: a randomized controlled trial. Diabetes 2006; 55: 3566–3572.
Cooper PL, Wahlqvist ML, Simpson RW. Sucrose versus saccharin as an added sweetener in non-insulin-dependent diabetes: short- and medium-term metabolic effects. Diabet Med 1988; 5: 676–680.
Groen JJ, Balogh M, Yaron E, Cohen AM. Effect of interchanging bread and sucrose as main source of carbohydrate in a low fat diet on the serum cholesterol levels of healthy volunteer subjects. Am J Clin Nutr 1966; 19: 46–58.
Lowndes J, Kawiecki D, Pardo S, Nguyen V, Melanson KJ, Yu Z et al. The effects of four hypocaloric diets containing different levels of sucrose or high fructose corn syrup on weight loss and related parameters. Nutr J 2012; 11: 55.
Maersk M, Belza A, Stodkilde-Jorgensen H, Ringgaard S, Chabanova E, Thomsen H et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr 2012; 95: 283–289.
Marckmann P, Raben A, Astrup A. Ad libitum intake of low-fat diets rich in either starchy foods or sucrose: effects on blood lipids, factor vii coagulant activity, and fibrinogen. Metabolism 2000; 49: 731–735.
Raben A, Vasilaras T, Møller A, Astrup A. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr 2002; 76: 721–729.
Sorensen LB, Raben A, Stender S, Astrup A. Effect of sucrose on inflammatory markers in overweight humans. Am J Clin Nutr 2005; 82: 421–427.
Stanhope K, Griffen S, Bair B, Swarbrick M, Kelm N, Havel P. Twenty four hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr 2008; 87: 1194–1203.
Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T et al. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-b in young men and women. J Clin Endocrinol Metab 2011; 96: E1596–E1605.
Miller M, Stone N, Ballantyne C, Bittner V, Criqui M, Ginsberg H et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 2011; 123: 2292–2333.
Lowndes J, Sinnett S, Pardo S, Nguyen V, Melanson K, Yu Z et al. The effect of normally consumed amounts of sucrose or high fructose corn syrup on body composition and related parameters in overweight/obese subjects. Nutrients 2014; 6: 1128–1144.
Chiavaroli L, Mirrahimi A, De Souza RJ, Cozma AI, Ha V, Wang DD et al. Does fructose consumption elicit a dose-response effect on fasting triglycerides? A systematic review and meta-regression of controlled feeding trials. Can J Diabetes 2012; 36: S37.
Wang D, Sievenpiper JL, de Souza RJ, Cozma AI, Chiavaroli L, Ha V et al. Effect of fructose on postprandial triglycerides: A systematic review and meta-analysis of controlled feeding trials. Atherosclerosis 2014; 232: 125–133.
Obarzanek E, Sacks F, Vollmer W, Bray G, Miller E III, Lin P et alDASH Research Group. Effects on blood lipids of a blood pressure-lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Clin Nutr 2001; 74: 80–89.
Howard B, Van Horn L, Hsia J, Manson J, Stefanick M, Wassertheil-Smoller S et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006; 295: 655–666.
Stanhope KL, Havel PJ. Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol 2008; 19: 16–24.
Marckmann P. Dietary treatment of thrombogenic disorders related to the metabolic syndrome. Br J Nutr 2000; 83 (Suppl 1): S121–S126.
Johnson R, Segal M, Sautin Y, Nakagawa T, Feig D, Kang D et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007; 86: 899–906.
Feig D, Soletsky B, Johnson R. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 2008; 300: 924–932.
Ha V, Sievenpiper J, de Souza R, Chiavaroli L, Wang D, Cozma A et al. Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials. Hypertension 2012; 59: 787–795.
Nguyen S, Choi H, Lustig R, Hsu C. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 2009; 154: 807–813.
Bremer A, Auinger P, Byrd R. Relationship between insulin resistance-associated metabolic parameters and anthropometric measurements with sugar-sweetened beverage intake and physical activity levels in US adolescents: findings from the 1999–2004 National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 2009; 163: 328–335.