Epidemiology and Population Health

Women’s reproductive health factors and body adiposity: findings from the UK Biobank

Abstract

Objective:

To conduct a comprehensive examination of the association between women’s reproductive health factors and measures of body adiposity in a contemporary Western population.

Methods:

A cross-sectional analysis of 502 664 individuals from the UK Biobank was conducted. Multivariable linear regression models were used to examine the association of age at menarche, age at first birth, parity and age at menopause with measures of general and central body adiposity, adjusted for age, smoking and socioeconomic status. The association between number of children and body adiposity in men was also assessed.

Results:

Age at menarche was inversely associated with body mass index (BMI); adjusted mean BMI was 29.0 kg m–2 in women with menarche before the age of 12 years, compared with 26.5 kg m–2 in those who had menarche after 14 years of age. Age at first birth was linearly and inversely associated with BMI: 0.16 kg m–2 lower BMI per year increase in age of first birth. Each additional live birth or child fathered was associated with a 0.22 kg m–2 higher BMI in women and a 0.14 kg m−2 higher BMI in men. There was no evidence for an association between age at menopause and BMI. Corresponding associations for other markers of general or abdominal adiposity were similar to those for BMI. Findings were broadly similar in analyses stratified by age, smoking status, socioeconomic status, ethnic background, and history of diabetes or cardiovascular disease.

Conclusions:

In women from a contemporary Western population, earlier age at menarche and age at first birth, and higher number of total live births were associated with higher levels of body adiposity. Prospective evaluations of the association between reproductive health factors, adiposity and the onset of cardiometabolic diseases are needed to assess causality, and to explore the mechanisms involved.

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References

  1. 1

    Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384: 766–781.

  2. 2

    Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380: 2224–2260.

  3. 3

    Newby PK, Dickman PW, Adami HO, Wolk A . Early anthropometric measures and reproductive factors as predictors of body mass index and obesity among older women. Int J Obes 2005; 29: 1084–1092.

  4. 4

    Trikudanathan S, Pedley A, Massaro JM, Hoffmann U, Seely EW, Murabito JM et al. Association of female reproductive factors with body composition: the Framingham Heart Study. J Clin Endocrinol Metab 2013; 98: 236–244.

  5. 5

    Prentice P, Viner RM . Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis. Biomed Res Int 2013; 37: 1036–1043.

  6. 6

    Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sorensen TI et al. Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 2008; 121 (Suppl 3): S172–S191.

  7. 7

    Lewington S, Li L, Murugasen S, Hong LS, Yang L, Guo Y et al. Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie biobank study of 300 000 women. Int J Epidemiol 2014; 43: 1252–1262.

  8. 8

    Morris DH, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ . Secular trends in age at menarche in women in the UK born 1908-93: results from the Breakthrough Generations Study. Paediatr Perinat Epidemiol 2011; 25: 394–400.

  9. 9

    Chen L, Zhang C, Yeung E, Ye A, Mumford SL, Wactawski-Wende J et al. Age at menarche and metabolic markers for type 2 diabetes in premenopausal women: the BioCycle Study. J Clin Endocrinol Metab 2011; 96: E1007–E1012.

  10. 10

    Akahoshi M, Soda M, Nakashima E, Tsuruta M, Ichimaru S, Seto S et al. Effects of age at menopause on serum cholesterol, body mass index, and blood pressure. Atherosclerosis 2001; 156: 157–163.

  11. 11

    Cohen SS, Larson CO, Matthews CE, Buchowski MS, Signorello LB, Hargreaves MK et al. Parity and breastfeeding in relation to obesity among black and white women in the southern community cohort study. J Womens Health (Larchmt) 2009; 18: 1323–1332.

  12. 12

    Bobrow KL, Quigley MA, Green J, Reeves GK, Beral V . Persistent effects of women's parity and breastfeeding patterns on their body mass index: results from the Million Women Study. Int J Obes (Lord) 2013; 37: 712–717.

  13. 13

    Koch E, Bogado M, Araya F, Romero T, Diaz C, Manriquez L et al. Impact of parity on anthropometric measures of obesity controlling by multiple confounders: a cross-sectional study in Chilean women. J Epidemiol Community Health 2008; 62: 461–470.

  14. 14

    Allen N, Sudlowa C, Downey P, Peakman T, Danesh J, Elliott P et al. UK Biobank: Current status and what it means for epidemiology. Health Policy Technol 2012; 1: 123–126.

  15. 15

    Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 2015; 12: e1001779.

  16. 16

    Townsend material deprivation score for output areas in England - based on Census 2001, 2004. http://www.erpho.org.uk/viewResource.aspx?id=9070.

  17. 17

    Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 2011; 377: 1085–1095.

  18. 18

    Parr CL, Batty GD, Lam TH, Barzi F, Fang X, Ho SC et al. Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424,519 participants. Lancet Oncol 2010; 11: 741–752.

  19. 19

    Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009; 373: 1083–1096.

  20. 20

    Janghorbani M, Mansourian M, Hosseini E . Systematic review and meta-analysis of age at menarche and risk of type 2 diabetes. Acta Diabetol 2014; 51: 519–528.

  21. 21

    Charalampopoulos D, McLoughlin A, Elks CE, Ong KK . Age at menarche and risks of all-cause and cardiovascular death: a systematic review and meta-analysis. Am J Epidemiol 2014; 180: 29–40.

  22. 22

    Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C et al. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 2010; 42: 1077–1085.

  23. 23

    Fernandez-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T et al. Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. Am J Epidemiol 2013; 178: 451–460.

  24. 24

    Casey VA, Dwyer JT, Coleman KA, Krall EA, Gardner J, Valadian I . Accuracy of recall by middle-aged participants in a longitudinal study of their body size and indices of maturation earlier in life. Ann Hum Biol 1991; 18: 155–166.

  25. 25

    Koprowski C, Coates RJ, Bernstein L . Ability of young women to recall past body size and age at menarche. Obes Res 2001; 9: 478–485.

  26. 26

    Must A, Phillips SM, Naumova EN, Blum M, Harris S, Dawson-Hughes B et al. Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember? Am J Epidemiol 2002; 155: 672–679.

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Acknowledgements

This research has been conducted using the UK Biobank Resource. Ethics and permission: UK Biobank has obtained Research Tissue Bank approval from its governing Research Ethics Committee, as recommended by the National Research Ethics Service. No separate ethics approval was required. Permission to use the UK Biobank Resource was approved by the Access Sub-Committee of the UK Biobank Board.

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Correspondence to S A E Peters.

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The authors declare no conflict of interest.

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Supplementary Information accompanies this paper on International Journal of Obesity website

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Peters, S., Huxley, R. & Woodward, M. Women’s reproductive health factors and body adiposity: findings from the UK Biobank. Int J Obes 40, 803–808 (2016). https://doi.org/10.1038/ijo.2015.254

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