Govindarajan VS, Sathyanarayana MN. Capsicum—production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Crit Rev Food Sci Nutr 1991; 29: 435–474.
Reilly CA, Crouch DJ, Yost GS. Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products. J Forensic Sci 2001; 46: 502–509.
Collins MD, Wasmund LM, Bosland PW. Improved method for quantifying capsaicinoids in Capsicum using high-performance liquid chromatography. Hort Sci 1995; 30: 137–139.
Suzuki T, Kawada T, Iwai K. Biosynthesis of acyl moieties of capsaicin and its analogues from valine and leucine in capsium fruits. Plant Cell Physiol 1981; 22: 23–32.
Contri RV, Frank LA, Kaiser M, Pohlmann AR, Guterres SS. The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids. Int J Nanomed 2014; 9: 951–962.
Watanabe T, Kawada T, Iwai K. Effect of capsaicin pretreatment on capsaicin-induced catecholamine secretion from the adrenal medulla in rats. Proc Soc Exp Biol Med 1988; 187: 370–374.
Watanabe T, Kawada T, Yamamoto M, Iwai K. Capsaicin, a pungent principle of hot red pepper, evokes catecholamine secretion from the adrenal medulla of anesthetized rats. Biochem Biophys Res Commun 1987; 142: 259–264.
Iwai K, Yazaua A, Watanabe T. Roles as metabolic regulators of the non-nutrients, capsaicin and capsiate, supplemented to diets. Proc Jpn Acad 2003; 79: 207–212.
Shintaku K, Uchida K, Suzuki Y, Zhou Y, Fushiki T, Watanabe T et al. Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br J Pharmacol 2012; 165: 1476–1486.
Yoshida T, Yoshioka K, Wakabayashi Y, Nishioka H, Kondo M. Effects of capsaicin and isothiocyanate on thermogenesis of interscapular brown adipose tissue in rats. J Nutr Sci Vitaminol (Tokyo) 1988; 34: 587–594.
Kawada T, Hagihara K, Iwai K. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr 1986; 116: 1272–1278.
Kawada T, Suzuki T, Takahashi M, Iwai K. Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol Appl Pharmacol 1984; 72: 449–456.
Kawada T, Watanabe T, Takaishi T, Tanaka T, Iwai K. Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 1986; 183: 250–256.
Matsumoto T, Miyawaki C, Ue H, Yuasa T, Miyatsuji A, Moritani T. Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women. J Nutr Sci Vitaminol (Tokyo) 2000; 46: 309–315.
Clegg ME, Golsorkhi M, Henry CJ. Combined medium-chain triglyceride and chilli feeding increases diet-induced thermogenesis in normal-weight humans. Eur J Nutr 2013; 52: 1579–1585.
Ryan ED, Beck TW, Herda TJ, Smith AE, Walter AA, Stout JR et al. Acute effects of a thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during low-intensity exercise, and recovery from exercise. J Strength Cond Res 2009; 23: 807–817.
Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M et al. Effects of red-pepper diet on the energy metabolism in men. J Nutr Sci Vitaminol (Tokyo) 1995; 41: 647–656.
Inoue N, Matsunaga Y, Satoh H, Takahashi M. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem 2007; 71: 380–389.
Galgani JE, Ravussin E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am J Clin Nutr 2010; 92: 1089–1093.
Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009; 89: 45–50.
Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 1998; 80: 503–510.
Yoshioka M, St-Pierre S, Drapeau V, Dionne I, Doucet E, Suzuki M et al. Effects of red pepper on appetite and energy intake. Br J Nutr 1999; 82: 115–123.
Yoshioka M, Doucet E, Drapeau V, Dionne I, Tremblay A. Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 2001; 85: 203–211.
Westerterp-Plantenga MS, Smeets A, Lejeune MP. Sensory and gastrointestinal satiety effects of capsaicin on food intake. Int J Obes (Lond) 2005; 29: 682–688.
Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite 2012; 59: 341–348.
Whiting S, Derbyshire EJ, Tiwari B. Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data. Appetite 2014; 73: 183–188.
Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. The effect of 4-week chilli supplementation on metabolic and arterial function in humans. Eur J Clin Nutr 2007; 61: 326–333.
Ludy MJ, Mattes RD. The effects of hedonically acceptable red pepper doses on thermogenesis and appetite. Physiol Behav 2011; 102: 251–258.
Ludy MJ, Moore GE, Mattes RD. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012; 37: 103–121.
Belza A, Frandsen E, Kondrup J. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond) 2007; 31: 121–130.
Belza A, Jessen AB. Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation. Eur J Clin Nutr 2005; 59: 733–741.
Lopez HL, Ziegenfuss TN, Hofheins JE, Habowski SM, Arent SM, Weir JP et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr 2013; 10: 22.
Wahlqvist ML, Wattanapenpaiboon N. Hot foods—unexpected help with energy balance? Lancet 2001; 358: 348–349.
Sun D, Lv J, Chen W, Li S, Guo Y, Bian Z et al. Spicy food consumption is associated with adiposity measures among half a million Chinese people: the China Kadoorie Biobank study. BMC Public Health 2014; 14: 1293.
Al-Kassie GAM, Al-Nasrawi MAM, Ajeena SJ. The effects of using hot red pepper as a diet supplement on some performance traits in broiler. Pak J Nutr 2011; 10: 842–845.
Galgani JE, Ryan DH, Ravussin E. Effect of capsinoids on energy metabolism in human subjects. Br J Nutr 2010; 103: 38–42.
Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999; 51: 159–212.
Notani PN, Jayant K. Role of diet in upper aerodigestive tract cancers. Nutr Cancer 1987; 10: 103–113.
Lopez-Carrillo L, Hernandez Avila M, Dubrow R. Chili pepper consumption and gastric cancer in Mexico: a case–control study. Am J Epidemiol 1994; 139: 263–271.
Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S et al. A case–control study of gastric cancer and diet in Italy. Int J Cancer 1989; 44: 611–616.
Lin CH, Lu WC, Wang CW, Chan YC, Chen MK. Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells. BMC Complement Altern Med 2013; 13: 46.
Min JK, Han KY, Kim EC, Kim YM, Lee SW, Kim OH et al. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 2004; 64: 644–651.
Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am J Clin Nutr 2006; 84: 63–69.
Ahuja KD, Ball MJ. Effects of daily ingestion of chilli on serum lipoprotein oxidation in adult men and women. Br J Nutr 2006; 96: 239–242.
Chaiyasit K, Khovidhunkit W, Wittayalertpanya S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thai 2009; 92: 108–113.
Chularojmontri L, Suwatronnakorn M, Wattanapitayakul SK. Influence of capsicum extract and capsaicin on endothelial health. J Med Assoc Thai 2010; 93 (Suppl 2): S92–101.
Derry S, Sven-Rice A, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2013; 2: CD007393.
Morin CM, Gibson D, Wade J. Self-reported sleep and mood disturbance in chronic pain patients. Clin J Pain 1998; 14: 311–314.
Raymond I, Nielsen TA, Lavigne G, Manzini C, Choiniere M. Quality of sleep and its daily relationship to pain intensity in hospitalized adult burn patients. Pain 2001; 92: 381–388.
Sayar K, Arikan M, Yontem T. Sleep quality in chronic pain patients. Can J Psychiatry 2002; 47: 844–848.
Sabatowski R, Galvez R, Cherry DA, Jacquot F, Vincent E, Maisonobe P et al. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Pain 2004; 109: 26–35.
Chaput JP, Brunet M, Tremblay A. Relationship between short sleeping hours and childhood overweight/obesity: results from the 'Quebec en Forme' Project. Int J Obes (Lond) 2006; 30: 1080–1085.
Boule NG, Chaput JP, Doucet E, Richard D, Despres JP, Bouchard C et al. Glucose homeostasis predicts weight gain: prospective and clinical evidence. Diabetes Metab Res Rev 2008; 24: 123–129.
Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004; 141: 846–850.
Brondel L, Romer MA, Nougues PM, Touyarou P, Davenne D. Acute partial sleep deprivation increases food intake in healthy men. Am J Clin Nutr 2010; 91: 1550–1559.
Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Benedict C, Lehnert H et al. Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr 2009; 90: 1476–1482.
Chaput JP, Tremblay A. Sleeping habits predict the magnitude of fat loss in adults exposed to moderate caloric restriction. Obes Facts 2012; 5: 561–566.
Nedeltcheva AV, Kilkus JM, Imperial J, Schoeller DA, Penev PD. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med 2010; 153: 435–441.
Rosenbaum M, Kissileff HR, Mayer LE, Hirsch J, Leibel RL. Energy intake in weight-reduced humans. Brain Res 2010; 1350: 95–102.
Doucet E, St-Pierre S, Almeras N, Despres JP, Bouchard C, Tremblay A. Evidence for the existence of adaptive thermogenesis during weight loss. Br J Nutr 2001; 85: 715–723.
Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332: 621–628.
Doucet E, Imbeault P, St-Pierre S, Almeras N, Mauriege P, Despres JP et al. Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. Clin Sci (Lond) 2003; 105: 89–95.
Doucet E, Imbeault P, St-Pierre S, Almeras N, Mauriege P, Richard D et al. Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord 2000; 24: 906–914.
Doucet E, St-Pierre S, Almeras N, Tremblay A. Relation between appetite ratings before and after a standard meal and estimates of daily energy intake in obese and reduced obese individuals. Appetite 2003; 40: 137–143.
Janssens PL, Hursel R, Martens EA, Westerterp-Plantenga MS. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance. PLoS One 2013; 8: e67786.
Janssens PL, Hursel R, Westerterp-Plantenga MS. Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance. Appetite 2014; 77: 44–49.
Smeets AJ, Janssens PL, Westerterp-Plantenga MS. Addition of capsaicin and exchange of carbohydrate with protein counteract energy intake restriction effects on fullness and energy expenditure. J Nutr 2013; 143: 442–447.
Lejeune MP, Kovacs EM, Westerterp-Plantenga MS. Effect of capsaicin on substrate oxidation and weight maintenance after modest body-weight loss in human subjects. Br J Nutr 2003; 90: 651–659.
Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 2007; 292: R77–R85.