Table 1C Gene expression in SAT according to obesity and type 2 diabetes

From: CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss

  Non-obese Obese Obese-T2D P-value
N 13 47 23  
PPARG (R.U.) 0.018±0.01 0.009±0.004a 0.0086±0.0045a <0.0001
GLUT4 (R.U.) 0.045±0.02 0.043±0.028 0.025±0.012 0.08
IRS1 (R.U.) 0.015±0.01 0.011±0.006 0.009±0.003 0.07
STAMP2 (R.U.) 0.12±0.04 0.11±0.03 0.14±0.04 0.19
FASN (R.U.) 0.35±0.3 0.076±0.05a 0.055±0.045a 0.003
ACACA (R.U.) 0.043±0.04 0.022±0.02 0.016±0.008a 0.01
LEP (R.U.) 0.70±0.42 0.85±0.32 0.81±0.32 0.5
PPARGC1A (R.U.) 0.008±0.008 0.006±0.005 0.0064±0.0052 0.5
PPARGC1B (R.U.) 0.001±0.0005 0.0008±0.0003 0.0008±0.0003 0.2
TFAM (R.U.) 0.011±0.003 0.010±0.004 0.0098±0.003 0.3
MT-CO3 (R.U.) 29.08±10.1 22.6±7.9 21.3±5.9a 0.019
PLIN1 (R.U.) 1.37±0.6 1.36±1.01 1.24±0.54 0.8
CIDEC/FSP27 (R.U.) 1.29±0.74 1.01±0.49 0.94±0.36 0.1
  1. Abbreviations: ACACA, acetyl-CoA carboxylase alpha; CIDEC/FSP27, cell death-inducing DFFA-like effector c; FASN, fatty acid synthase; GLUT4, solute carrier family 2 (facilitated glucose transporter), member 4; IRS1, insulin receptor substrate 1; LEP, leptin; MT-CO3, cytochrome c oxidase III; PLIN1, perilipin 1; PPARG, peroxisome proliferator-activated receptor gamma; PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PPARGC1B, peroxisome proliferator-activated receptor gamma, coactivator 1 beta; R.U., relative gene expression unit; SAT, subcutaneous adipose tissue; STAMP2, STEAP family member 4; TFAM, transcription factor A, mitochondrial; VAT, visceral adipose tissue.
  2. aP<0.05 in comparison with non-obese subjects (with Bonferroni Post Hoc tests). Bold values denote P<0.05.