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Body mass index across midlife and cognitive change in late life

International Journal of Obesity volume 37, pages 296–302 (2013)Cite this article

Subjects

Abstract

Background:

High midlife body mass index (BMI) has been linked to a greater risk of dementia in late life, but few have studied the effect of BMI across midlife on cognitive abilities and cognitive change in a dementia-free sample.

Methods:

We investigated the association between BMI, measured twice across midlife (mean age 40 and 61 years, respectively), and cognitive change in four domains across two decades in the Swedish Adoption/Twin Study of Aging.

Results:

Latent growth curve models fitted to data from 657 non-demented participants showed that persons who were overweight/obese in early midlife had significantly lower cognitive performance across domains in late life and significantly steeper decline in perceptual speed, adjusting for cardio-metabolic factors. Both underweight and overweight/obesity in late midlife were associated with lower cognitive abilities in late life. However, the association between underweight and low cognitive abilities did not remain significant when weight decline between early and late midlife was controlled for.

Conclusion:

There is a negative effect on cognitive abilities later in life related to being overweight/obese across midlife. Moreover, weight decline across midlife rather than low weight in late midlife per se was associated with low cognitive abilities. Weight patterns across midlife may be prodromal markers of late life cognitive health.

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Acknowledgements

This study is supported by the National Institute of Aging (AG04563, AG10175, AG08724), the MacArthur Foundation Research Network on Successful Aging, the Swedish Council for Working Life and Social Research (FAS; 97:0147:1B, 2009-0795, postdoc Grant 2010-0704, FLARE postdoc Grant 2010-1852), the Swedish Research Council (825-2007-7460, 825-2009-6141) and The Bank of Sweden Tercentenary Foundation.

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Authors and Affiliations

  1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    A K Dahl, M Gatz & N L Pedersen

  2. Institute of Gerontology, School of Health Sciences, Jönköping University, Jönköping, Sweden

    A K Dahl

  3. Department of Psychology, University of Gothenburg, Gothenburg, Sweden

    L B Hassing

  4. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    E I Fransson

  5. Department of Natural Sciences and Biomedicine, School of Health Sciences, Jönköping University, Jönköping, Sweden

    E I Fransson

  6. Department of Psychology, University of Southern California, Los Angeles, CA, USA

    M Gatz & N L Pedersen

  7. Department of Psychology, University of California Riverside, Riverside, CA, USA

    C A Reynolds

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  1. A K Dahl
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Correspondence to A K Dahl.

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Dahl, A., Hassing, L., Fransson, E. et al. Body mass index across midlife and cognitive change in late life. Int J Obes 37, 296–302 (2013). https://doi.org/10.1038/ijo.2012.37

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