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Shorter telomeres are associated with obesity and weight gain in the elderly

Abstract

Objective:

Obesity and shorter telomeres are commonly associated with elevated risk for age-related diseases and mortality. Whether telomere length (TL) may be associated with obesity or variations in adiposity is not well established. Therefore, we set out to test the hypothesis that TL may be a risk factor for increased adiposity using data from a large population-based cohort study.

Design:

Levels of adiposity were assessed in six ways (obesity status, body mass index (BMI), the percentage of body fat or % body fat, leptin, visceral and subcutaneous fat mass) in 2721 elderly subjects (42% black and 58% white). Associations between TL measured in leukocytes at baseline and adiposity traits measured at baseline, and three of these traits after 7 years of follow-up were tested using regression models adjusting for important covariates. Additionally, we look at weight changes and relative changes in BMI and % body fat between baseline and follow-up.

Results:

At baseline, TL was negatively associated with % body fat (ß=−0.35±0.09, P=0.001) and subcutaneous fat (ß=−2.66±1.07, P=0.01), and positively associated with leptin after adjusting for % body fat (ß=0.32±0.14, P=0.001), but not with obesity, BMI or visceral fat. Prospective analyses showed that longer TL was associated with positive percent change between baseline and 7-year follow-up for both BMI (ß=0.48±0.20, P=0.01) and % body fat (ß=0.42±0.23, P=0.05).

Conclusion:

Our study suggests that shorter TL may be a risk factor for increased adiposity. Coupling with previous reports on their reversed roles, the relationship between adiposity and TL may be complicated and may warrant more prospective studies.

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References

  1. Lahmann PH, Lissner L, Gullberg B, Berglund G . A prospective study of adiposity and all-cause mortality: the Malmo Diet and Cancer Study. Obes Res 2002; 10: 361–369.

    Article  Google Scholar 

  2. Reilly JJ, Kelly J . Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int J Obes 2011; 35: 891–898.

    CAS  Google Scholar 

  3. Reis JP, Araneta MR, Wingard DL, Macera CA, Lindsay SP, Marshall SJ . Overall obesity and abdominal adiposity as predictors of mortality in U.S. white and black adults. Ann Epidemiol 2009; 19: 134–142.

    Article  Google Scholar 

  4. Rankin JW, Andreae MC, Oliver Chen CY, O’Keefe SF . Effect of raisin consumption on oxidative stress and inflammation in obesity. Diabetes Obes Metab 2008; 10: 1086–1096.

    Article  CAS  Google Scholar 

  5. Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P et al. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochem Pharmacol 2009; 78: 1391–1400.

    Article  CAS  Google Scholar 

  6. Suzuki K, Ito Y, Ochiai J, Kusuhara Y, Hashimoto S, Tokudome S et al. Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese. Asian Pac J Cancer Prev 2003; 4: 259–266.

    PubMed  Google Scholar 

  7. Halvorsen TL, Beattie GM, Lopez AD, Hayek A, Levine F . Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol 2000; 166: 103–109.

    Article  CAS  Google Scholar 

  8. Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD . Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004; 117: 2417–2426.

    Article  CAS  Google Scholar 

  9. von Zglinicki T, Saretzki G, Docke W, Lotze C . Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995; 220: 186–193.

    Article  CAS  Google Scholar 

  10. Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci USA 2007; 104: 12135–12139.

    Article  CAS  Google Scholar 

  11. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 2007; 165: 14–21.

    Article  Google Scholar 

  12. Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA . Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393–395.

    Article  CAS  Google Scholar 

  13. Calado RT, Young NS . Telomere diseases. N Engl J Med 2009; 361: 2353–2365.

    Article  CAS  Google Scholar 

  14. Carroll KA, Ly H . Telomere dysfunction in human diseases: the long and short of it!. Int J Clin Exp Pathol 2009; 2: 528–543.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Terasaki Y, Okumura H, Ohtake S, Nakao S . Accelerated telomere length shortening in granulocytes: a diagnostic marker for myeloproliferative diseases. Exp Hematol 2002; 30: 1399–1404.

    Article  CAS  Google Scholar 

  16. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005; 366: 662–664.

    Article  CAS  Google Scholar 

  17. Zannolli R, Mohn A, Buoni S, Pietrobelli A, Messina M, Chiarelli F et al. Telomere length and obesity. Acta Paediatr 2008; 97: 952–954.

    Article  CAS  Google Scholar 

  18. Al-Attas OS, Al-Daghri NM, Alokail MS, Alfadda A, Bamakhramah A, Sabico S et al. Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin. Eur J Endocrinol 2010; 163: 601–607.

    Article  CAS  Google Scholar 

  19. MacEneaney OJ, Kushner EJ, Westby CM, Cech JN, Greiner JJ, Stauffer BL et al. Endothelial progenitor cell function, apoptosis, and telomere length in overweight/obese humans. Obesity 2010; 18: 1677–1682.

    Article  CAS  Google Scholar 

  20. Diaz VA, Mainous AG, Player MS, Everett CJ . Telomere length and adiposity in a racially diverse sample. Int J Obes 2010; 34: 261–265.

    Article  CAS  Google Scholar 

  21. O’Callaghan NJ, Clifton PM, Noakes M, Fenech M . Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res 2009; 12: 169–176.

    Article  Google Scholar 

  22. Cawthon RM . Telomere measurement by quantitative PCR. Nucleic Acids Res 2002; 30: e47.

    Article  Google Scholar 

  23. Rimm EB, Stampfer MJ, Giovannucci E, Ascherio A, Spiegelman D, Colditz GA et al. Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. Am J Epidemiol 1995; 141: 1117–1127.

    Article  CAS  Google Scholar 

  24. Folsom AR, Kushi LH, Anderson KE, Mink PJ, Olson JE, Hong CP et al. Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. Arch Intern Med 2000; 160: 2117–2128.

    Article  CAS  Google Scholar 

  25. Moreno-Navarrete JM, Ortega F, Sabater M, Ricart W, Fernandez-Real JM . Telomere length of subcutaneous adipose tissue cells is shorter in obese and formerly obese subjects. Int J Obes 2010; 34: 1345–1348.

    Article  CAS  Google Scholar 

  26. Nordfjall K, Eliasson M, Stegmayr B, Melander O, Nilsson P, Roos G . Telomere length is associated with obesity parameters but with a gender difference. Obesity 2008; 16: 2682–2689.

    Article  Google Scholar 

  27. Farzaneh-Far R, Lin J, Epel E, Lapham K, Blackburn E, Whooley MA . Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. PLoS One 2010; 5: e8612.

    Article  Google Scholar 

  28. Al-Attas OS, Al-Daghri N, Bamakhramah A, Shaun Sabico S, McTernan P, Huang TT . Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. Acta Paediatr 2010; 99: 896–899.

    Article  CAS  Google Scholar 

  29. Youngren K, Jeanclos E, Aviv H, Kimura M, Stock J, Hanna M et al. Synchrony in telomere length of the human fetus. Hum Genet 1998; 102: 640–643.

    Article  CAS  Google Scholar 

  30. Friedrich U, Griese E, Schwab M, Fritz P, Thon K, Klotz U . Telomere length in different tissues of elderly patients. Mech Ageing Dev 2000; 119: 89–99.

    Article  CAS  Google Scholar 

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Acknowledgements

This study was supported in part by the Intramural Research Program of the National Institute on Aging, NIH contracts (N01-AG-6-2101, N01-AG-6-2103 and N01-AG-6-2106) and grants (K01 AG022782 and R01 AG023692). Dr OT Njajou is supported by the Training in Molecular and Genetic Epidemiology of Cancer, National Institutes of Health, National Cancer Institute grant (R25 CA112355).

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Correspondence to W-C Hsueh.

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Njajou, O., Cawthon, R., Blackburn, E. et al. Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes 36, 1176–1179 (2012). https://doi.org/10.1038/ijo.2011.196

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  • DOI: https://doi.org/10.1038/ijo.2011.196

Keywords

  • telomere length
  • adiposity
  • telomeres
  • aging

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