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Brain size, body size and longevity


In this analysis, we bring together two research fields that have never been associated before: the clinical issue ‘Quételet's body-mass index and longevity’ and the comparative biological issue ‘body–brain allometry’. Comparison of medical and biological data supports the view that body mass index is just a one-to-one mapping of the body–brain–energy balance—a biological variable indicating that an individual maintains its systemic energy homeostasis and therefore is likely to perform well in the coming years.

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  1. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009; 373: 1083–1096.

    Article  Google Scholar 

  2. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008; 359: 2105–2120.

    Article  CAS  Google Scholar 

  3. Bales CW, Buhr GT . Body mass trajectory, energy balance, and weight loss as determinants of health and mortality in older adults. Obes Facts 2009; 2: 171–178.

    Article  Google Scholar 

  4. Quételet MA . A Treatise on Man and the Development of His Faculties. William and Robert Chambers: Edinburgh, 1842.

    Google Scholar 

  5. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003; 421: 182–187.

    Article  CAS  Google Scholar 

  6. Taguchi A, Wartschow LM, White MF . Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007; 317: 369–372.

    Article  CAS  Google Scholar 

  7. Armstrong E . Relative brain size and metabolism in mammals. Science 1983; 220: 1302–1304.

    Article  CAS  Google Scholar 

  8. Mink JW, Blumenschine RJ, Adams DB . Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis. Am J Physiol 1981; 241: R203–R212.

    CAS  PubMed  Google Scholar 

  9. Martin RD . Relative brain size and basal metabolic rate in terrestrial vertebrates. Nature 1981; 293: 57–60.

    Article  CAS  Google Scholar 

  10. Glazier DS . Beyond the ‘3/4-power law’: variation in the intra- and interspecific scaling of metabolic rate in animals. Biol Rev Camb Philos Soc 2005; 80: 611–662.

    Article  Google Scholar 

  11. Hofman MA . Energy metabolism, brain size and longevity in mammals. Q Rev Biol 1983; 58: 495–512.

    Article  CAS  Google Scholar 

  12. Hofman MA . Encephalization and the evolution of longevity in mammals. J Evol Biol 1993; 6: 209–227.

    Article  Google Scholar 

  13. Peters A, Schweiger U, Pellerin L, Hubold C, Oltmanns KM, Conrad M et al. The selfish brain: competition for energy resources. Neurosci Biobehav Rev 2004; 28: 143–180.

    Article  CAS  Google Scholar 

  14. Aiello LC, Wheeler P . The expensive-tissue hypothesis: the brain and the digestive system in human and primate evolution. Curr Anthropol 1995; 36: 199–221.

    Article  Google Scholar 

  15. Krieger M . On the atrophy of human organs in inanition. Z Angew Anat Konstitutionsl 1921; 7: 87–134.

    Google Scholar 

  16. Oltmanns KM, Melchert UH, Scholand-Engler HG, Howitz MC, Schultes B, Schweiger U et al. Differential energetic response of brain vs. skeletal muscle upon glycemic variations in healthy humans. Am J Physiol Regul Integr Comp Physiol 2008; 294: R12–R16.

    Article  CAS  Google Scholar 

  17. Later W, Bosy-Westphal A, Hitze B, Kossel E, Glüer C-C, Heller M et al. No evidence of mass dependency of specific organ metabolic rate in healthy humans. Am J Clin Nutr 2008; 88: 1004–1009.

    Article  CAS  Google Scholar 

  18. Sokoloff L . Circulation & energy metabolism of the brain. In: Siegel G, Agranoff B, Albers RW, Molinoff P (eds). Basic Neurochemistry. Raven Press: New York, 1989, pp 565–590.

    Google Scholar 

  19. Peters A, Langemann D . Build-ups in the supply chain of the brain: on the neuroenergetic cause of obesity and type 2 diabetes mellitus. Front Neuroenergetics 2009; 1: 2.

    Article  Google Scholar 

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This work was supported by grants from the German Research Foundation (DFG Mü 714/8-3 and Clinical Research Group KFO-126).

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Correspondence to A Peters.

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Peters, A., Hitze, B., Langemann, D. et al. Brain size, body size and longevity. Int J Obes 34, 1349–1352 (2010).

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  • brain size
  • body size
  • body mass index
  • longevity

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