Mice were divided into two distinct feeding groups, as depicted in Figure 1b. The effects of these feeding regimes on caloric intake (a), body weight (b), percent body fat (c), glucose tolerance (d), as well as energy expenditure, respiratory quotient, and physical activity (e) were determined. Data are shown as mean +/− s.e.m. for 5–25-independent observations. * denotes P<0.05 main diet effect and $ denotes P<0.05 diet effect at a specific ZT.