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Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants

International Journal of Obesity volume 35, pages 744–747 (2011)Cite this article

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Abstract

There is emerging evidence that persistent organic pollutants (POPs) can increase the risk of various chronic diseases. As POPs mainly bioaccumulate in adipose tissue, weight change can affect serum concentrations of POPs. However, there are few population-based studies on effects of long-term weight change on serum concentrations of POPs. We examined associations between self-reported weight change over 1 year and 10 years and serum concentrations of seven POPs in 1099 adults aged ⩾40. Serum concentrations of most POPs were higher in those with long-term weight loss, whereas they were lower in those with long-term weight gain. Adjusted correlation coefficients of each POP with weight change for 10 years were −0.23 (P<0.01) for trans-nonachlor, −0.16 (P<0.01) for p,p′-dichlorodiphenyldichloroethylene, and −0.21 (P<0.01) for β-hexachlorocyclohexane, −0.16 (P<0.01) for PCB169, −0.20 (P<0.01) for PCB180 and −0.17 (P<0.01) for 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin. Weight change for 1 year showed similar but weaker associations, compared with those of long-term weight changes. Although both beneficial health effects after weight loss and harmful health effects after weight gain are generally expected, changes in serum concentrations of POPs in relation to weight change may act on health in directions opposite to what we expect with weight change.

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Authors and Affiliations

  1. Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea

    J S Lim, H-K Son, S-K Park & D-H Lee

  2. Department of Preventive Medicine, School of Medicine, Eulji University, Daejeon, Korea

    J S Lim

  3. Department of Occupational and Environmental Medicine, CHA Gumi Medical Center, CHA University, Kyungsangbuk-do, Korea

    H-K Son

  4. Department of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA

    D R Jacobs Jr

  5. Department of Nutrition, University of Oslo, Oslo, Norway

    D R Jacobs Jr

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  1. J S Lim
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Correspondence to D-H Lee.

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Lim, J., Son, HK., Park, SK. et al. Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants. Int J Obes 35, 744–747 (2011). https://doi.org/10.1038/ijo.2010.188

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Keywords

  • adipose tissue
  • persistent organic pollutants (POPs)
  • weight gain
  • weight loss

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