Table 5 Association of FTO genotype with T2DM

From: Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study

   FTO rs9939609 Allele frequency Additive model
   TT TA AA Odds P Adjusted odds P
This study T2DM 305 164 23 1.21 0.112 1.18a 0.175
  Control 252 116 12 (0.96–1.54)   (0.93–1.51)  
Horikawa et al.16 T2DM 1165 596 88 1.03 0.678 1.03a 0.68
  Control 995 520 63 (0.91–1.15)   (0.91–1.15)  
Horikoshi et al.17 T2DM 528 298 38 1.17 0.070 1.10b 0.27
  Control 573 251 40 (0.99–1.38)   (0.92–1.32)  
Omori et al.18 T2DM 1026 513 82 1.09 0.209 1.11a 0.238
  Control 681 334 38 (0.95–1.25)   (0.93–1.33)  
Meta-analyzed      1.09   1.08  
      (1.01–1.17)   (0.99–1.17)  
  1. Abbreviation: T2DM, type 2 diabetes mellitus.
  2. Differences in allele frequency between T2DM and control subjects were assessed by χ2 analysis.
  3. aAdjusted odds ratio was calculated by logistic regression analysis with an additive genetic model adjusted for age, sex and body mass index.
  4. bAdjusted odds ratio was calculated by logistic regression analysis with an additive genetic model adjusted for age and sex.
  5. The pooled odds ratios for allele frequency and additive genetic model were estimated using the fixed effects model (Mantel–Haenszel method19 and variance-based method,20, 21 respectively).