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Treatments for obesity: view from the Chair

International Journal of Obesity volume 33, pages S22–S23 (2009)Cite this article

The control of body weight involves a complex interplay between a variety of factors. Genetics, culture, environment, mood, and the types and tastes of foods around us all can influence our body weight and adiposity. This complexity is not itself a problem, but problems arise when adiposity increases beyond a limit and we must identify a specific cause for obesity. Reducing body weight permanently is far more difficult for most overweight people than it is to gain weight in the first place. Thus, reports on hormones that regulate appetite or on bariatric surgical procedures with unexpected endocrine benefits are greeted with great interest. This review focuses on two papers that deal with such issues.

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References

  1. Lutz TA . Control of food intake and energy expenditure by amylin—therapeutic implications. Int J Obes 2009; 33 (Suppl 1): S24–S27.

    Article  CAS  Google Scholar 

  2. Lutz TA, Del Prete E, Scharrer E . Reduction of food intake in rats by intraperitoneal injection of low doses of amylin. Physiol Behav 1994; 55: 891–895.

    Article  CAS  PubMed  Google Scholar 

  3. Lutz TA . Amylinergic control of food intake. Physiol Behav 2006; 89: 465–471.

    Article  CAS  PubMed  Google Scholar 

  4. Pulman KJ, Fry WM, Cottrell GT, Ferguson AV . The subfornical organ: a central target for circulating feeding signals. J Neurosci 2006; 26: 2022–2030.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Jobst EE, Enriori PJ, Cowley MA . The electrophysiology of feeding circuits. Trends Endocrinol Metab 2004; 15: 488–499.

    Article  CAS  PubMed  Google Scholar 

  6. Irani BG, Dunn-Meynell AA, Levin BE . Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology 2007; 148: 310–316.

    Article  CAS  PubMed  Google Scholar 

  7. Tadross JA, le Roux CW . The mechanisms of weight loss after bariatric surgery. Int J Obes 2009; 33 (Suppl 1): S28–S32.

    Article  Google Scholar 

  8. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357: 741–752.

    Article  PubMed  Google Scholar 

  9. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004; 292: 1724–1737.

    Article  CAS  PubMed  Google Scholar 

  10. Rubino F . Bariatric surgery: effects on glucose homeostasis. Curr Opin Clin Nutr Metab Care 2006; 9: 497–507.

    Article  CAS  PubMed  Google Scholar 

  11. le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006; 243: 108–114.

    Article  PubMed  Google Scholar 

  12. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623–1630.

    Article  PubMed  Google Scholar 

  13. Korner J, Bessler M, Cirilo LJ, Conwell IM, Daud A, Restuccia NL et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 2005; 90: 359–365.

    Article  CAS  PubMed  Google Scholar 

  14. Cummings DE . Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery. Int J Obes 2009; 33 (Suppl 1): S33–S40.

    Article  CAS  Google Scholar 

  15. Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 2003; 238: 467–484.

    PubMed  PubMed Central  Google Scholar 

  16. Laferrère B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 2008; 93: 2479–2485.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

WF Colmers is a Medical Scientist of the Alberta Heritage Foundation for Medical Research. Work in his laboratory is supported by the Canadian Institutes for Health Research.

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  1. Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada

    W F Colmers

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  1. W F Colmers
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Correspondence to W F Colmers.

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Colmers, W. Treatments for obesity: view from the Chair. Int J Obes 33 (Suppl 1), S22–S23 (2009). https://doi.org/10.1038/ijo.2009.12

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