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Treatments for obesity: view from the Chair

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  1. Lutz TA . Control of food intake and energy expenditure by amylin—therapeutic implications. Int J Obes 2009; 33 (Suppl 1): S24–S27.

    Article  CAS  Google Scholar 

  2. Lutz TA, Del Prete E, Scharrer E . Reduction of food intake in rats by intraperitoneal injection of low doses of amylin. Physiol Behav 1994; 55: 891–895.

    Article  CAS  PubMed  Google Scholar 

  3. Lutz TA . Amylinergic control of food intake. Physiol Behav 2006; 89: 465–471.

    Article  CAS  PubMed  Google Scholar 

  4. Pulman KJ, Fry WM, Cottrell GT, Ferguson AV . The subfornical organ: a central target for circulating feeding signals. J Neurosci 2006; 26: 2022–2030.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Jobst EE, Enriori PJ, Cowley MA . The electrophysiology of feeding circuits. Trends Endocrinol Metab 2004; 15: 488–499.

    Article  CAS  PubMed  Google Scholar 

  6. Irani BG, Dunn-Meynell AA, Levin BE . Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology 2007; 148: 310–316.

    Article  CAS  PubMed  Google Scholar 

  7. Tadross JA, le Roux CW . The mechanisms of weight loss after bariatric surgery. Int J Obes 2009; 33 (Suppl 1): S28–S32.

    Article  Google Scholar 

  8. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357: 741–752.

    Article  PubMed  Google Scholar 

  9. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004; 292: 1724–1737.

    Article  CAS  PubMed  Google Scholar 

  10. Rubino F . Bariatric surgery: effects on glucose homeostasis. Curr Opin Clin Nutr Metab Care 2006; 9: 497–507.

    Article  CAS  PubMed  Google Scholar 

  11. le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg 2006; 243: 108–114.

    Article  PubMed  Google Scholar 

  12. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346: 1623–1630.

    Article  PubMed  Google Scholar 

  13. Korner J, Bessler M, Cirilo LJ, Conwell IM, Daud A, Restuccia NL et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 2005; 90: 359–365.

    Article  CAS  PubMed  Google Scholar 

  14. Cummings DE . Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery. Int J Obes 2009; 33 (Suppl 1): S33–S40.

    Article  CAS  Google Scholar 

  15. Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg 2003; 238: 467–484.

    PubMed  PubMed Central  Google Scholar 

  16. Laferrère B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab 2008; 93: 2479–2485.

    Article  PubMed  PubMed Central  Google Scholar 

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WF Colmers is a Medical Scientist of the Alberta Heritage Foundation for Medical Research. Work in his laboratory is supported by the Canadian Institutes for Health Research.

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Correspondence to W F Colmers.

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Colmers, W. Treatments for obesity: view from the Chair. Int J Obes 33 (Suppl 1), S22–S23 (2009).

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