Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter

Abstract

Objective:

Emerging evidence suggests that exposures during fetal life affect adult metabolism. We assessed the relationship between recalled maternal pre-pregnancy body mass, gestational weight gain (GWG), and adiposity in the daughter.

Design:

Retrospective cohort study among mother–nurse daughter dyads in the Nurses’ Health Study II and the Nurses’ Mothers’ Cohort. Mothers of participants completed questionnaires regarding their nurse daughter in 2001.

Participants:

26,506 mother–nurse daughter dyads born between 1946 and 1964.

Main outcome measures:

Body mass index (BMI) of the nurse daughter at age 18 and in 2001.

Results:

At age 18, 561 (2.1%) daughters were obese (BMI>30), and in 2001, 5442 (22.0%) were obese. Adjusting for covariates, women whose mothers had a recalled pre-pregnancy BMI of 29 had a 6.1-fold increased risk of obesity at age 18 and a 3.4-fold risk of obesity in 2001, compared with women whose mothers had a pre-pregnancy BMI of 21. We found a U-shaped association between recalled GWG and offspring obesity. Compared with a maternal weight gain of 15–19 lb, GWG <10 lb was associated with a significant increase in obesity risk at age 18 (odds ratio (OR) 1.54, 95% confidence interval (CI) 1.02–2.34) and in 2001 (OR 1.27, 95% CI 1.05–1.53). High weight gain (40+lb) was also associated with obesity risk at age 18 (OR 1.81, 95% CI 1.22–2.69) and in 2001 (OR 1.74, 95% CI 1.48–2.04). These associations were stronger among mothers who were overweight before pregnancy (P for interaction=0.03), and they persisted with adjustment for birth weight.

Conclusion:

A high recalled pre-pregnancy BMI and extremes of recalled GWG are associated with an increased risk of adolescent and adult obesity in offspring, particularly when the mother is overweight. Pre-pregnancy weight and GWG may be modifiable fetal origins of overweight and obesity in women.

Introduction

Associations between fetal growth and risk of metabolic disease later in life have been suggested in multiple studies.1, 2, 3, 4, 5, 6, 7 Birth weight has been used as a proxy for in utero nutrition; infants that are born small have restricted access to nutrients during development, leading to a thrifty phenotype. In later life, catch-up growth among individuals who were small at birth is associated with greater fat, compared with lean, tissue accumulation, reduced insulin sensitivity in muscle, and central adiposity.8 At the other extreme, high birth weight (>4000 g) has also been associated with an increased risk for obesity and metabolic disease, attributed to overnutrition in utero.4

In 1990, the Institute of Medicine’ Subcommittee on Nutritional Status and Weight Gain During Pregnancy concluded that low maternal gain was a significant risk factor for low birth weight.9 The subcommittee examined observational data and identified the mean weight gain associated with birth weights of 3000–4000 g. These findings formed the basis for the current recommendations of 25–35 lb of gain for normal BMI women, 28–40 lb of gain for low BMI women, and 15–25 lb of gain for overweight women. At the time, evidence regarding appropriate gain for obese women was limited. The subcommittee recommended at least 15 lb of gain for this group, because ‘it seems prudent to recommend that obese women gain a minimum equivalent to the weight of the products of conception.’ In 2006, the Institute of Medicine convened a workshop on the Influence of Pre-pregnancy Weight on Maternal and Child Health to review more recent data.10 Many participants suggested a revision of the 1990 guidelines given more recent demographic trends, including rising rates of obesity and declining rates of low birth weight. The Institute of Medicine revised guidelines for weight gain in May 2009, recommending 11 to 20 lbs of gestational gain for women who were obese prior to pregnancy.11

Both maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) affect fetal growth,12 but few long-term studies are available regarding the role of these anthropometric characteristics in predicting the offspring's long-term disease risk. Studies suggest that, with provider guidance, women are more likely to gain weight appropriately during pregnancy.13, 14 Understanding how maternal BMI and GWG influences long-term risk of obesity in offspring may, therefore, allow expectant mothers and their care providers to reduce risks for obesity in the next generation. We, therefore, analyzed the relationship between recalled maternal pre-pregnancy BMI, GWG, adolescent (age 18), and adult adiposity in the nurse daughters who are participants of the Nurses’ Health Study II (NHS II).

Materials and methods

Population

The NHS II is a large, prospective cohort study of 116,608 female nurses from 14 US states. Enrollment began in 1989, when the nurses were 25–44 years old. In 2001, mothers of women in the cohort were invited to complete a questionnaire regarding their nurse daughter. The Nurses’ Mothers’ Cohort included nurses who were free of cancer and whose mothers were alive in 2001. Data on pregnancy and early life exposures were obtained from 35,826 mother–daughter dyads. Ninety-seven percent of participants are non-Hispanic whites.

Our cohort was limited to nurses whose mothers were alive and able to respond to our questionnaire in 2001, potentially enriching our study group with healthier mothers and daughters. Compared with nurses whose mothers did not complete the 2001 questionnaire, our study population had a slightly lower BMI at age 18 (mean±s.d.: 21.1±3.2 vs 21.3±3.4, t-test with equal variance P<0.001). Women in our study group were also less likely to have a mother with diabetes (4.2 vs 8.7%, χ2 P<0.001). This was expected because mothers with diabetes would be at higher risk of dying earlier than mothers without diabetes.

Assessment of exposures

Mothers reported weight gain during the pregnancy with their nurse daughter as a categorical variable in the following categories: <10, 10–14, 15–19, 20–29, 30–40, >40 lb, or do not remember. They also reported their height and usual weight before the index pregnancy and responded to a variety of questions regarding pregnancy complications and outcome. The following data reported by the mothers were included in our study: the nurse daughter's birth weight, due date for the pregnancy, whether the nurse daughter was a twin and whether she was adopted, severity, duration, treatment of pregnancy-associated nausea and vomiting, pregnancy complications including high blood pressure and pre-eclampsia, use of tobacco, level of physical activity during the pregnancy, infant feeding practices (any breastfeeding vs no breastfeeding), and birth order of the daughter. Socio-economic data included home ownership at the time of the nurse daughter's birth, cohabitation with the father, father's educational attainment, and father's occupation. The mothers also reported the father's weight and height at the time of the daughter's birth. Daughters reported parental history of diabetes on the 1989 and 1997 questionnaires.

Assessment of outcome

Participants of the NHS II reported their current height and their weight at age 18 on the 1989 questionnaire. Self-reported weight at age 18 in this cohort has been validated earlier.15 Participants reported current weight on the 2001 questionnaire when they were 36–56 years old. We defined overweight as BMI25 and <30, and we defined obese as BMI30.

Exclusions

We excluded nurses from our study population who were adopted (n=88) or were missing data on the following: BMI at age 18 (n=274), maternal GWG (n=2811), or maternal pre-pregnancy BMI (n=1533). In addition, we excluded subjects who were members of a twin pregnancy (n=543), whose mother's pregnancies were complicated by pre-eclampsia (n=1002), or for whom gestational age at delivery was not known (n=3069). Subjects with missing data on BMI in 2001 (n=1755) were excluded from the analysis of adult BMI. We used a missing indicator variable for participants’ missing covariate data.

Statistical analysis

We performed univariate logistic regression to assess the relationship between individual predictors and outcome. We used analysis of variance and χ2 tests to assess the relationship between GWG and continuous and categorical covariates, respectively. To assess whether any associations between GWG or pre-pregnancy weight and obesity in the daughter persisted beyond adolescence, we also modeled these associations with daughters’ obesity in 2001, when the mothers’ questionnaire was administered. We used multinomial logistic regression to model the relationship between GWG and the end points of overweight or obesity at age 18 in the daughter, using daughters with a BMI<25 as the comparison group. To prevent over fitting of the model, only variables that were considered a priori predictors of offspring's obesity were tested for inclusion in our model.

We hypothesized that GWG would have a U-shaped relationship with offspring's risk of obesity, because both low and high birth weights have been associated with metabolic disease in adulthood.2 We, therefore, chose the GWG category associated with the lowest mean BMI at age 18 in the daughter as the reference group for the analysis of obesity at age 18, and we used the same referent category for the analysis of obesity in 2001. Maternal pre-pregnancy BMI, maternal age, and paternal BMI were treated as continuous variables. For the analysis of obesity in 2001, we adjusted for the nurses’ age at the time of the 2001 questionnaire. Maternal and paternal history of diabetes, smoking status, pregnancy-associated nausea and vomiting, maternal physical activity, birth order, and demographic variables were modeled as categorical variables. Only those covariates that added significantly to the model (likelihood ratio test P<0.05) or changed the parameter estimates for the exposure by >10% remained in the models. We tested linearity of associations with continuous variables by adding a quadratic term to the model. Quadratic terms were retained if they were statistically significant.

Some authors have reported differential under-reporting of weight among higher-BMI women.16 We, therefore, performed a sensitivity analysis to test whether such under-reporting would alter any association between GWG and offspring obesity. We similarly tested whether differential under-reporting of GWG category by overweight mothers would alter observed associations.

We hypothesized that birth weight might mediate the association between GWG, maternal pre-pregnancy BMI, and obesity in the daughter. To test its role as an intermediate variable, we added birth weight to the multivariable model. As birth weight has been shown to have a U-shaped association with adult obesity, it was treated as a categorical variable (<2500, 2500 to <3000, 3000 to <3500, 3500 to <4000, 4000 to <4500, and 4500 g or more).

We hypothesized that the association between GWG and adiposity in the daughter would be modified by maternal pre-pregnancy BMI. To test this hypothesis, we stratified our population by maternal pre-pregnancy BMI (<25 kg/m2 vs >=25 kg/m2) and performed multinomial regression in the two groups to assess the association between GWG category and obesity in the daughter. We further used multivariable linear regression to model BMI at age 18 and in 2001, assessing the interaction between BMI, BMI squared, and GWG treated categorically.

Statement of ethics

We certify that all applicable institutional and governmental regulations concerning the ethical use of human volunteers were followed during this research. The Institutional Review Boards of the Brigham and Women's Hospital and the National Cancer Institute approved the study.

Results

Among a total of 26,506 mother–daughter dyads, 561 daughters were obese at age 18 (2.1%), and 1802 were overweight (6.8%). BMI in 2001 was available for 24,751 nurse daughters, among whom 5442 (22.0%) were obese and 6576 (26.6%) were overweight. Among the nurses’ mothers, 6.2% were overweight and 0.8% were obese before pregnancy.

Sixty-four percent of mothers gained weight between 15 and 29 lb during their pregnancy with their nurse daughter, whereas 3.5% gained <10 lb and 5.0% gained >40 lb. Maternal BMI before pregnancy, gestational age at delivery, and infant birth weight were linearly associated with GWG (Table 1). Both high and low extremes of weight gain were associated with parental history of diabetes, smoking during pregnancy, first pregnancy, and indicators of lower socio-economic status. Maternal pre-pregnancy BMI was linearly related to maternal and paternal diabetes history, paternal BMI, birth weight of the nurse daughter, and low GWG (Table 2). Mothers with higher BMIs before pregnancy were less likely to be primiparous, less likely to report nausea and vomiting or high physical activity during pregnancy, and less likely to have breastfed their nurse daughter. Partners of women with higher BMIs were less likely to have a professional job or a college degree.

Table 1 Parental characteristics in relation to recalled gestational weight gain
Table 2 Parental characteristics in relation to recalled maternal pre-pregnancy BMI

In the unadjusted multinomial regression model, maternal weight gain was significantly associated with both overweight and obesity at age 18, with increased odds of each outcome at both low and high extremes of GWG (Table 3). We observed the lowest risk of the daughter's obesity among women who gained 15–19 lb. Maternal pre-pregnancy BMI attenuated this association (Table 3). Adjusting for maternal pre-pregnancy BMI, <10 lb of gestational gain was associated with a 1.73-fold increase in the odds of obesity in the daughter, compared with 15–19 lb of gain. At the other extreme, >40 lb of weight gain was associated with a maternal BMI-adjusted 2.13-fold increase in odds of obesity in the daughter. Adjustment for other covariates modestly attenuated the association between extremes of GWG and the odds of obesity at age 18. The relationship differed for overweight. After adjustment for maternal BMI, low weight gain was no longer significantly associated with increased odds of overweight at age 18. Weight gain >40 lb remained significantly associated, with a 1.55-fold increase in odds of overweight at age 18, compared with subjects whose mothers gained 15–19 lb. Further adjustment for other covariates did not materially change the pattern of association.

Table 3 ORs for obesity and overweight of 26,512 participants of the NHS II at age 18 by recalled gestational weight gain of the mother

When we added birth weight to our model, the odds ratio (OR) for obesity at high and low extremes of gestational gain was slightly attenuated, but remained statistically significant. Similarly, high weight gain remained a significant predictor of overweight at age 18 with adjustment for birth weight (Table 3).

The association between GWG category and obesity in the daughter differed depending on the maternal pre-pregnancy BMI (likelihood ratio test P for mother overweight × GWG category interaction=0.03). Among daughters of normal weight mothers, we found increased odds of obesity at age 18 with 10–14 lb of gain (OR 1.54, 95% confidence interval (CI) 1.08–2.20), compared with 15–19 lb of gain. Point estimates suggested an increased risk for weight gain <10 lb or >30 lb, but CIs were wide. Among daughters of overweight women, the association between extremes of maternal GWG and obesity was stronger for <10 lb, OR 2.42, 95% CI 1.14–5.16, and for 40+lb, OR 3.56, 95% CI 1.47–8.59, compared with 15–19 lb of weight gain.

In our sensitivity analysis, we tested whether systematic under-reporting of BMI among women in the highest quartile of pre-pregnancy BMI would affect our results. Incrementing BMI by 2 kg/m2 in this group did not change the observed association between GWG and obesity in the daughter. We similarly tested whether differential under-reporting of weight gain category by mothers who were overweight at the time of their pregnancy would affect our results. In our differentially reclassified models, the strength of the association between extremes of weight gain and offspring obesity was attenuated; however, we continued to find an increased odds of obesity in the daughter with 10–14 or >30 lb of maternal GWG when we modeled the effect of 20% of overweight mothers under-reporting their weight gain category.

We found similar results for the association between maternal GWG and offspring's obesity in adulthood. In the age-adjusted multinomial model, a U-shaped association between GWG and both obesity and overweight appeared (Table 4). These associations were confounded by maternal pre-pregnancy BMI. In the fully adjusted model, maternal gain of <10 lb was associated with a 1.27-fold higher odds of obesity in adulthood. Daughters of mothers who gained >40 lb had a 1.74-fold odds of obesity and a 1.27-fold odds of overweight in adulthood. Adjustment for birth weight of the daughter did not appreciably modify this association.

Table 4 ORs for obesity and overweight in 2001 of participants of the NHS II by recalled gestational weight gain of the mother

Both maternal pre-pregnancy BMI and the square of maternal pre-pregnancy BMI were significantly related to offspring adiposity both at age 18 and in 2001. We used our multinomial model to predict the ORs for obesity for mothers with pre-pregnancy BMIs between 21 and 29. Small increments in BMI were associated with substantially increased odds of obesity and overweight. Compared with daughters of mothers with a pre-pregnancy BMI of 21, those whose mothers had a pre-pregnancy BMI of 23 had a covariate-adjusted 1.72-fold odds of obesity at age 18 and a 1.42-odds risk of obesity in 2001. Those participants whose mothers had a pre-pregnancy BMI of 29 had a covariate-adjusted 6.12-fold increased odds of obesity at age 18 and a 3.41-fold odds of obesity in 2001 (Tables 5 and 6), compared with those whose mothers had a pre-pregnancy BMI of 21. Paternal BMI was also associated with odds of overweight and obesity in the daughter, but the association was not as strong. Compared with daughters of fathers with a BMI of 21, those whose fathers had a BMI of 29 had a 3.6-fold risk of obesity at age 18 and a 2.5-fold risk of obesity in 2001.

Table 5 Predicted ORs for obesity and overweight at age 18 for participants of the NHS II by recalled pre-pregnancy BMIa of the mother
Table 6 Predicted ORs for obesity and overweight in 2001 for participants of the NHS II by recalled pre-pregnancy BMIa of the mother

In multivariable linear regression models of BMI at age 18 and in 2001, we found significant interactions between maternal pre-pregnancy BMI and GWG category (partial F-test P<0.01 for interactions in both models). Daughters whose mothers gained 15–19 lb had the lowest BMI at age 18 and in 2001. Higher maternal pre-pregnancy BMI was associated with a greater increase in the daughter's BMI with both low and high GWG (Figure 1).

Figure 1
figure1

Recalled maternal BMI, GWG, and predicted BMI in the daughter. Predicted BMI for first-born daughter of a non-smoker who experienced first trimester nausea was of mean maternal age, has no history of diabetes, and was married to a father of mean BMI with no history of diabetes and a high-school education.

Discussion

In this cohort of 35,826 mother–daughter pairs, maternal-recalled GWG above or below 15–19 lb in the index pregnancy was associated with an increased risk of adolescent and adult obesity in the daughter. This association was modest among normal weight mothers and stronger among mothers with higher pre-pregnancy BMIs. This association persisted with adjustment for parental BMI, maternal smoking during pregnancy, family history of diabetes, and socio-economic factors, as well as nurse's age in 2001. Mothers with a high recalled pre-pregnancy BMI were more likely to have daughters with a high BMI at age 18 and in 2001. To our knowledge, this is the first study to document an association between maternal GWG, maternal pre-pregnancy weight, and obesity in adult offspring—observations of acute relevance given the current obesity epidemic among childbearing women.

Our findings must be interpreted within the context of the study design. In this retrospective cohort study, data on pregnancy weight gain and associated exposures were collected 36–56 years after the daughter's birth. It is likely that mothers were aware of their weight gain at the time of the index pregnancy, because obstetrical texts during this time period emphasized the importance of both measuring weight at each prenatal visit and limiting maternal gain to prevent pre-eclampsia and other pregnancy complications.17, 18 Random misclassification of recalled weight gain would likely bias our results toward the null, but differential misclassification is a concern. In a study of short-term-recalled GWG, overweight or obese women were more likely to underreport weight at delivery. When self-reported delivery weight was used to calculate GWG, the resulting misclassification attenuated associations between weight gain and obstetrical outcomes.16 Therefore, we undertook our sensitivity analysis; our results remained fairly robust, even when we assumed that 20% of overweight mothers had under-reported their GWG.

Recalled pre-pregnancy BMI is also subject to measurement error. In our sensitivity analysis, we explored the effects of systematic under-reporting of pre-pregnancy BMI; we found that even under-reporting of 2 kg/m2 for maternal pre-pregnancy BMI among heavier women would not materially alter the association between GWG and obesity in the daughter. Moreover, in our study, the nurse daughters were asked about their body weight independent of maternal data collection, and their recall interval was limited to age 18 years or to reporting current weight. Any misclassification of GWG or maternal BMI would likely be non-differential with respect to the daughter's BMI. As a result, misclassification would underestimate, rather than overestimate, any true association.

Secular trends may limit the generalizability of our findings to a contemporary population. Of note, the lowest risk weight gain category, 15–19 lb, was the ‘recommended’ weight gain category during the era when these births occurred. Weight gain within these limits may be a marker for health-conscious behavior and as such, unmeasured confounders may have contributed to the association between weight gain and offspring obesity. Other changes in obstetrical practice limited our analysis. As women were not routinely screened for gestational diabetes mellitus (GDM) during the study period, we could not determine the role of GDM in this cohort. However, approximately 50% of women with GDM go on to develop type 2 diabetes, and adjustment for maternal history of type 2 diabetes did not alter the observed associations. In addition, our study population is limited to mothers of registered nurses, which comprise a limited socio-economic stratum, and this may further limit our ability to generalize our results.

Our results confirm and extend the earlier work on the association between in utero exposure and obesity in the offspring.5 Barker et al.19, 20 have proposed the developmental origins hypothesis, describing the relationship between low birth weight, catch-up growth, and adult cardiovascular disease. In epidemiologic studies, low birth weight is associated with higher odds of central adiposity.21, 22 Maternal undernutrition during pregnancy is similarly associated with obesity. Ravelli et al. reported an increased obesity risk among both adolescents and middle-aged adults who were exposed in utero to nutritional deprivation during the Dutch Famine.23, 24 These data suggest that maternal nutritional constraint may increase the offspring's risk of obesity.

At the other extreme, high birth weight is associated with higher BMI in childhood,25 early adolescence, 1 and adulthood.7, 26, 27 Birth weight is influenced by GWG,28 although this relationship seems to be modified by maternal pre-pregnancy BMI.12 The relationship between GWG and neonatal body composition also seems to vary by maternal BMI. Among normal weight women, Sewell et al. 29 reported that maternal weight gain is associated with lean body mass, whereas among overweight women, gestational gain is associated with neonatal fat mass. These observations are consistent with our finding that the impact of GWG on offspring obesity is modified by maternal BMI.

Oken et al. recently reported that high GWG is associated with increased risk of adiposity in children30 and adolescents,31 after adjusting for maternal BMI and other pregnancy parameters. In contrast, Whitaker3 did not observe a consistent association between quartiles of weight gain rate (total weight gain—birth weight/gestational age) and offspring's adiposity at ages 2–4. No studies to our knowledge have related maternal GWG to adiposity risk of the offspring in adulthood.

Our findings linking maternal BMI to offspring obesity confirm and extend the earlier studies of parental BMI and adult adiposity.32, 33, 34 Clearly, the biologic underpinning here may include genetic components, shared environment, as well as intrauterine metabolic programming, potentially through epigenetic mechanisms. Our observation that maternal BMI was more strongly associated than paternal BMI with obesity in the daughter suggests that the intrauterine environment acts synergistically with genetic factors to influence obesity risk. Lawlor et al. reported a stronger effect of maternal BMI than paternal on offspring adiposity at age 14,35 but two other studies have not confirmed a stronger maternal contribution to offspring obesity risk.36, 37 Although our study did not provide the opportunity to separate these factors explicitly, our observations would encourage avoidance of obesity at the time of conception.

We found stronger associations between maternal adiposity and offspring obesity at age 18 than in adulthood. This difference likely reflects the greater time between exposure in utero and the outcome of measured weight. Other predictors of adiposity, including diet, physical activity, and parity, are likely to have influenced weight change between age 18 and 2001, and these differences would attenuate the strength of the association between maternal and offspring adiposity.

Our results may inform current debate regarding GWG recommendations. As obesity rates among childbearing women continue to rise, clinicians have questioned whether obese women should be advised not to gain any weight during pregnancy.38 Such advice may not be appropriate given the increased adiposity in daughters that we observed among mothers with <15 lb of weight gain. At the same time, we found that high GWG increases the odds of adiposity in the daughter, and this effect is greater with higher maternal BMI. This finding underscores the need for effective clinical interventions to prevent excessive weight gain during pregnancy and break the cycle of intergenerational obesity.28

In conclusion, our data suggest that both constrained and excessive maternal weight gain during pregnancy, as well as a high pre-pregnancy BMI, are associated with adolescent and adult adiposity in the daughter. These associations are stronger when the mother was overweight before pregnancy, and they are independent of other parental and childhood risk factors. These findings suggest that maternal pre-pregnancy obesity and maternal weight gain during pregnancy may be modifiable risk factors for offspring metabolic disease.

References

  1. 1

    Gillman MW, Rifas-Shiman S, Berkey CS, Field AE, Colditz GA . Maternal gestational diabetes, birth weight, and adolescent obesity. Pediatrics 2003; 111: e221–e226.

    Article  Google Scholar 

  2. 2

    Rich-Edwards JW, Colditz GA, Stampfer MJ, Willett WC, Gillman MW, Hennekens CH et al. Birthweight and the risk for type 2 diabetes mellitus in adult women. Ann Intern Med 1999; 130: 278–284.

    CAS  Article  Google Scholar 

  3. 3

    Whitaker RC . Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy. Pediatrics 2004; 114: e29–e36.

    Article  Google Scholar 

  4. 4

    Boney CM, Verma A, Tucker R, Vohr BR . Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005; 115: e290–e296.

    Article  Google Scholar 

  5. 5

    Oken E, Gillman MW . Fetal origins of obesity. Obes Res 2003; 11: 496–506.

    Article  Google Scholar 

  6. 6

    Mcmillen IC, Robinson JS . Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 2005; 85: 571–633.

    CAS  Article  Google Scholar 

  7. 7

    Curhan GC, Chertow GM, Willett WC, Spiegelman D, Colditz GA, Manson JE et al. Birth weight and adult hypertension and obesity in women. Circulation 1996; 94: 1310–1315.

    CAS  Article  Google Scholar 

  8. 8

    Dulloo AG . Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance. Best Pract Res Clin Endocrinol Metab 2008; 22: 155–171.

    CAS  Article  Google Scholar 

  9. 9

    Institute of Medicine. Nutrition During Pregnancy. National Academies Press: Washington, DC, 1990.

  10. 10

    National Research Council and Institute of Medicine. Influence of Pregnancy Weight on Maternal and Child Health. Workshop Report. The National Academies Press: Washington, DC, 2007.

  11. 11

    Rasmussen KM, Yaktine AL, eds. Weight Gain During Pregnancy: Reexamining the Guidelines; Institute of Medicine; National Research Council. 2009. http://www.nap.edu/catalog/12584.html

  12. 12

    Abrams BF, Laros Jr RK . Prepregnancy weight, weight gain, and birth weight. Am J Obstet Gynecol 1986; 154: 503–509.

    CAS  Article  Google Scholar 

  13. 13

    Olson C, Strawderman M, Reed R . Efficacy of an intervention to prevent excessive gestational weight gain. Am J Obstet Gynecol 2004; 191: 530–536.

    Article  Google Scholar 

  14. 14

    Cogswell M, Scanlon K, Fein S, Schieve L . Medically advised, mother's personal target, and actual weight gain during pregnancy. Obstet Gynecol 1999; 94: 616–622.

    CAS  PubMed  Google Scholar 

  15. 15

    Troy LM, Hunter DJ, Manson JE, Colditz GA, Stampfer MJ, Willett WC . The validity of recalled weight among younger women. Int J Obes Relat Metab Disord 1995; 19: 570–572.

    CAS  Google Scholar 

  16. 16

    Schieve L, Perry G, Cogswell M, Scanion K, Rosenberg D, Carmichael S et al. Validity of self-reported pregnancy delivery weight: an analysis of the 1988 National Maternal and Infant Health Survey. NMIHS Collaborative Working Group. Am J Epidemiol 1999; 150: 947–956.

    CAS  Article  Google Scholar 

  17. 17

    Lull CB, Kimbrough RA . Clinical Obstetrics. J.B. Lippicott Company: Philadelphia, PA, 1953.

    Google Scholar 

  18. 18

    Eastman NJ, Hellman LM . Williams Obstetrics 12th edn Appleton-Century-Crofts, Inc.: New York, 1961.

    Google Scholar 

  19. 19

    Barker D, Eriksson J, Forsen T, Osmond C . Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 2002; 31: 1235–1239.

    CAS  Article  Google Scholar 

  20. 20

    Barker DJ . Fetal origins of coronary heart disease. BMJ 1995; 311: 171–174.

    CAS  Article  Google Scholar 

  21. 21

    Okosun IS, Liao Y, Rotimi CN, Dever GE, Cooper RS . Impact of birth weight on ethnic variations in subcutaneous and central adiposity in American children aged 5–11 years. A study from the Third National Health and Nutrition Examination Survey. Int J Obes Relat Metab Disord 2000; 24: 479–484.

    CAS  Article  Google Scholar 

  22. 22

    Law CM, Barker DJ, Osmond C, Fall CH, Simmonds SJ . Early growth and abdominal fatness in adult life. J Epidemiol Community Health 1992; 46: 184–186.

    CAS  Article  Google Scholar 

  23. 23

    Ravelli AC, van Der Meulen JH, Osmond C, Barker DJ, Bleker OP . Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr 1999; 70: 811–816.

    CAS  Article  Google Scholar 

  24. 24

    Ravelli GP, Stein ZA, Susser MW . Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976; 295: 349–353.

    CAS  Article  Google Scholar 

  25. 25

    Dubois L, Girard M . Early determinants of overweight at 4.5 years in a population-based longitudinal study. Int J Obes (Lond) 2006; 30: 610–617.

    CAS  Article  Google Scholar 

  26. 26

    Sorensen HT, Sabroe S, Rothman KJ, Gillman M, Fischer P, Sorensen TI . Relation between weight and length at birth and body mass index in young adulthood: cohort study. BMJ 1997; 315: 1137.

    CAS  Article  Google Scholar 

  27. 27

    Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ . Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996; 94: 3246–3250.

    CAS  Article  Google Scholar 

  28. 28

    Catalano PM, Ehrenberg HM . The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG 2006; 113: 1126–1133.

    CAS  Article  Google Scholar 

  29. 29

    Sewell MF, Huston-Presley L, Super DM, Catalano P . Increased neonatal fat mass, not lean body mass, is associated with maternal obesity. Am J Obstet Gynecol 2006; 195: 1100–1103.

    Article  Google Scholar 

  30. 30

    Oken E, Taveras EM, Kleinman KP, Rich-Edwards JW, Gillman MW . Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol 2007; 196: e321–e328.

    Article  Google Scholar 

  31. 31

    Oken E, Rifas-Shiman SL, Field AE, Frazier AL, Gillman MW . Maternal gestational weight gain and offspring weight in adolescence. Obstet Gynecol 2008; 112: 999–1006.

    Article  Google Scholar 

  32. 32

    Terry MB, Wei Y, Esserman D . Maternal, birth, and early-life influences on adult body size in women. Am J Epidemiol 2007; 166: 5–13.

    Article  Google Scholar 

  33. 33

    Stettler N, Tershakovec AM, Zemel BS, Leonard MB, Boston RC, Katz SH et al. Early risk factors for increased adiposity: a cohort study of African American subjects followed from birth to young adulthood. Am J Clin Nutr 2000; 72: 378–383.

    CAS  Article  Google Scholar 

  34. 34

    Laitinen J, Power C, Jarvelin M-R . Family social class, maternal body mass index, childhood body mass index, and age at menarche as predictors of adult obesity. Am J Clin Nutr 2001; 74: 287–294.

    CAS  Article  Google Scholar 

  35. 35

    Lawlor DA, Smith GD, O’Callaghan M, Alati R, Mamun AA, Williams GM et al. Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the Mater-University Study of Pregnancy and its outcomes. Am J Epidemiol 2007; 165: 418–424.

    Article  Google Scholar 

  36. 36

    Kivimaki M, Lawlor DA, Smith GD, Elovainio M, Jokela M, Keltikangas-Jarvinen L et al. Substantial intergenerational increases in body mass index are not explained by the fetal overnutrition hypothesis: the Cardiovascular Risk in Young Finns Study. Am J Clin Nutr 2007; 86: 1509–1514.

    CAS  Article  Google Scholar 

  37. 37

    Davey Smith G, Steer C, Leary S, Ness A . Is there an intrauterine influence on obesity? Evidence from parent child associations in the Avon Longitudinal Study of Parents and Children (ALSPAC). Arch Dis Child 2007; 92: 876–880.

    Article  Google Scholar 

  38. 38

    Artal R, Catanzaro RB, Gavard JA, Mostello DJ, Friganza JC . A lifestyle intervention of weight-gain restriction: diet and exercise in obese women with gestational diabetes mellitus. Appl Physiol Nutr Metab 2007; 32: 596–601.

    Article  Google Scholar 

Download references

Acknowledgements

Preliminary findings were presented at the Society for Maternal Fetal Medicine, San Francisco, California, February 2007. The NHS II is supported by Public Health Service grant CA50385 from the National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services. The Nurses’ Mothers’ Cohort Study was funded by the Intramural Research Program of the National Cancer Institute (to MRF)—research contract N02-RC-17027 from the National Cancer Institute, and by PO 263 MQ 411027 from the National Cancer Institute (to KBM). One of the study authors (MRF) was a member of the Intramural Program at The National Cancer Institute at the time the Nurses’ Mothers’ Cohort study was designed and the data were collected. For this manuscript, the National Cancer Institute had no involvement in the analysis and interpretation of the data, or in the preparation, review, or approval of the manuscript. The authors had full access to the data for the study.

Author information

Affiliations

Authors

Corresponding author

Correspondence to A M Stuebe.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Stuebe, A., Forman, M. & Michels, K. Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter. Int J Obes 33, 743–752 (2009). https://doi.org/10.1038/ijo.2009.101

Download citation

Keywords

  • pregnancy
  • gestational weight gain
  • prenatal programming
  • birth weight

Further reading

Search