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Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime

International Journal of Obesity volume 32, pages 1875–1878 (2008)Cite this article

Abstract

The aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2′,4,4′,5,5′-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)>30 kg/m2; age 21–74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19–25 kg/m2; age 21–64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3±3.0 kg/m2. Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes.

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References

  1. Rignell-Hydbom A, Rylander L, Hagmar L . Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus. Hum Exp Toxicol 2007; 26: 447–452.

    Article  CAS  Google Scholar 

  2. Rylander L, Rignell-Hydbom A, Hagmar L . A cross-sectional study of the association between persistent organochlorine pollutants and diabetes. Environ Health 2005; 4: 28.

    Article  Google Scholar 

  3. Verner MA, Charbonneau M, López-Carrilo L, Haddad S . Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies. Environ Health Perspect 2008; 116: 886–892.

    Article  CAS  Google Scholar 

  4. Mullerova D, Kopecky J . White adipose tissue: storage and effector site for environmental pollutants. Physiol Res 2007; 56: 375–381.

    CAS  PubMed  Google Scholar 

  5. Rondinone CM . Adipocyte-derived hormones, cytokines, and mediators. Endocrine 2006; 29: 81–90.

    Article  CAS  Google Scholar 

  6. Vogel CF, Nishimura N, Sciullo E, Wong P, Li W, Matsumura F . Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. Arch Biochem Biophys 2007; 461: 169–175.

    Article  CAS  Google Scholar 

  7. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res 1999; 257: 79–83.

    Article  CAS  Google Scholar 

  8. Abbasi F, Chu JW, Lamendola C, McLaughlin T, Hayden J, Reaven GM et al. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 2004; 53: 585–590.

    Article  CAS  Google Scholar 

  9. Hotta K, Funahashi T, Arita Y . Plasma concentration of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thtomb Vasc Biol 2000; 20: 1595–1599.

    Article  CAS  Google Scholar 

  10. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidine-mediated improvement in insulin sensitivity. J Biol Chem 2004; 279: 12152–12162.

    Article  CAS  Google Scholar 

  11. Polak J, Kovacova Z, Jacek M, Klimcakova E, Kovacikova M, Vitkova M et al. An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women. Clin Sci (Lond) 2007; 112: 557–565.

    Article  CAS  Google Scholar 

  12. Karasek L, Hajslova J, Rosmus J, Huhnerfuss H . Methylsulfonyl PCB and DDE metabolites and their enantioselective gas chromatographic separation in human adipose tissues, seal blubber and pelican muscle. Chemosphere 2007; 67: S22–S27.

    Article  CAS  Google Scholar 

  13. Kern PA, Said S, Jackson Jr WG, Michalek JE . Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Clin Endocrinol Metab 2004; 89: 4665–4672.

    Article  CAS  Google Scholar 

  14. Arsenescu V, Arsenescu RI, King V, Swanson H, Cassis LA . Polychlorinated biphenyl 77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis. Environ Health Perspect 2008; 116: 761–768.

    Article  CAS  Google Scholar 

  15. Schrader TJ, Cooke GM . Effects of Aroclors and individual PCB congeners on activation of the human androgen receptor in vitro. Reprod Toxicol 2003; 17: 15–23.

    Article  CAS  Google Scholar 

  16. Yoshinari K, Sato T, Okino N, Sugatani J, Miwa M . Expression and induction of cytochromes P-450 in rat white adipose tissue. J Pharmacol Exp Ther 2004; 311: 147–154.

    Article  CAS  Google Scholar 

  17. Woodcroft KJ, Novak RF . Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther 1999; 289: 1121–1127.

    CAS  PubMed  Google Scholar 

  18. Yamazoe Y, Murayama N, Shimada M, Yamauchi K, Kato R . Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin. Arch Biochem Biophys 1989; 268: 567–575.

    Article  CAS  Google Scholar 

  19. Li CC, Lii CK, Liu KL, Yang JJ, Chen HW . n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. J Nutr Biochem 2006; 17: 707–715.

    Article  CAS  Google Scholar 

  20. Flachs P, Mohamed-Ali V, Horakova O, Rossmeisl M, Hosseinzadeh-Attar MJ, Hensler M et al. Polyunsaturated fattyacids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetology 2006; 49: 394–397.

    Article  CAS  Google Scholar 

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Acknowledgements

This work is dedicated to Professor K Opatrny Jr, in memorial, for his personal support of this research. Supported by Grant MSM 0021620819 ‘Replacement of and support to some vital organs’ Charles University, Medical School and Teaching Hospital Plzen, Czech Republic.

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Authors and Affiliations

  1. 1st Medical Department, Charles University Medical School and Teaching Hospital at Plzen, Plzen, Czech Republic,

    D Mullerova, D Matejkova, F Sefrna, S Opatrna & M Matejovic

  2. Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

    J Kopecky & O Kuda

  3. Department of Cybernetics, Faculty of Applied Sciences, University of West Bohemia, Plzen, Czech Republic

    L Muller

  4. Department of Chemistry, State Veterinary Institute Prague, Prague, Czech Republic

    J Rosmus

  5. Department of Clinical Biochemistry and Hematology, Charles University Medical School and Teaching Hospital at Plzen, Plzen, Czech Republic

    J Racek

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  1. D Mullerova
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  2. J Kopecky
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  4. L Muller
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  7. F Sefrna
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Correspondence to D Mullerova.

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Mullerova, D., Kopecky, J., Matejkova, D. et al. Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime. Int J Obes 32, 1875–1878 (2008). https://doi.org/10.1038/ijo.2008.169

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