This study aimed to evaluate the correlation between serum levels of fetuin-A and the presence and severity of erectile dysfunction (ED) in Egyptian population. The study was performed on 60 ED patients and 20 age—matched healthy controls. A comprehensive medical history and complete physical examination were obtained and performed in all participants. ED and its severity were assessed via International Index of Erectile Function (IIEF-5). Doppler ultrasound, fasting blood glucose level, complete lipid profile, serum total testosterone (TT) and serum fetuin-A were performed. Our results revealed that there were no statistically significant differences between the ED group and the controls regarding body mass index, fetal bovine serum, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG). However, IIEF-5 and serum TT levels were significantly lower in ED patients than controls. Regarding serum fetuin-A, our data demonstrated that ED patients had significantly lower serum fetuin-A levels than controls. In addition, patients with severe ED had lower fetuin-A levels than moderate and mild ED (P<0.001). Serum fetuin-A levels are positively correlated with cholesterol, LDL, TG and IIEF-5 and negatively correlated with HDL. In conclusion, serum fetuin-A level could be a potentially useful and sensitive biomarker for ED diagnosis.
Subscribe to Journal
Get full journal access for 1 year
only $32.38 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Smith LJ, Mulhall JP, Deveci S, Monaghan N, Reid MC . “Sex after seventy: a pilot study of sexual function in older persons”. J Sex Med 2007; 4: 1247–1253.
Maaroos PH, Palomaki A, Hartikainen J . Erectile dysfunction, physical activity, and metabolic syndrome: differences in markers of atherosclerosis. BMC Cardiovasc Disord 2011; 11: 36–44.
Shaeer O, Shaeer K . The Global Online Sexuality Survey (GOSS) erectile dysfunction among Arabic-speaking Internet users in the Middle East. J Sex Med 2011; 8: 2152–2160.
Bivalacqua TJ, Champion HC, Hellstrom WJG, Kadowitz PJ . “Pharmacotherapy for erectile dysfunction,”. Trends Pharmacol Sci 2000; 21: 484–489.
Lue TF . “Erectile dysfunction,”. N Engl J Med 2000; 342: 1802–1813.
Dean RC, Lue TF . Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am 2005; 32: 379–395.
Anderson K, Stief C . Penile erection and cardiac risk: pathophysiologic and pharmacologic mechanism. Am J Cardiol 2000; 86: 23F–26F.
Stein RA . Endothelial dysfunction, erectile dysfunction, and coronary heart disease: the pathophysiologic and clinical linkage. Rev Urol 2003; 5: S21–S27.
Billups KL . Sexual dysfunction and cardiovascular disease: integrative concepts and strategies. Am J Cardiol 2005; 96: 57–61.
Yao F, Huang Y, Zhang Y, Dong Y, Ma H, Deng C et al. Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease. Int J Androl 2012; 35: 653–659.
Pedersen KO . Fetuin, a New Globulin Isolated from Serum. Nature 1944; 154: 575–575.
Xu Y, Xu M, Bi Y, Song A, Huang Y, Liu Y et al. Serum fetuin-A is correlated with metabolic syndrome in middle-aged and elderly Chinese. Atherosclerosis 2011; 216: 180–186.
Nangami GN, Watson K, Parker-Johnson K, Okereke KO, Sakwe A, Thompson P et al. “Fetuin-A (ð¼2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel,”. Biochem Biophys Res Commun 2013; 438: 660–665.
Wojtysiak-Duma B, Malecha Jędraszek A, Burska A, Duma D, Donica H . Serum fetuin-A levels in patients with type 2 diabetes mellitus. Ann UMCS Sect DDD 2010; 2: 93–99.
Singh M, Sharma PK, Garg VK, Mondal SC, Singh AK, Kumar N . Role of fetuin-A in atherosclerosis associated with diabetic patients. J Pharm Pharmacol 2012; 64: 1703–1708.
Merx MW, Schafer C, Westenfeld R, Brandenburg V, Hidajat S, Weber C et al. Myocardial stiffness, cardiac remodeling, and diastolic dysfunction in calcification-prone fetuin-adeficient mice. J Am Soc Nephrol 2005; 16: 3357–3364.
Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319–326.
Lue TF . Erectile dysfunction. N Engl J Med 2000; 342: 1802–1813.
WHO. Developing sexual health programmes. A framework for action. 2002. Available at: http://whqlibdoc.who.int/hq/2010/WHO_RHR_HRP_10.22_eng.pdf.3.
Kirby M, Jackson G, Simonsen U . Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 2005; 59: 225–229.
Akalin N, Altiparmak MR, Trabulus S, Ataman R, Ayan F, Yetik H et al. Correlation of clinical effects with levels of fetuin-A, FGF-23 and intact parathyroid in peritoneal dialysis patients. Int J Biomed Adv Res 2015; 6: 488–494.
Song A, Xu M, Bi Y, Xu Y, Huang Y, Li M et al. Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults. PLoS One 2011; 6: e19228.
Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M et al. Facilitatory effects of fetuin-A on atherosclerosis. Atherosclerosis 2016; 246: 344–351.
Lim P, Moutereau S, Simon T, Gallet R, Probst V, Ferrieres J et al. Usefulness of fetuin-A and C-reactive protein concentrations for prediction of outcome in acute coronary syndromes (from the French Registry of Acute ST-Elevation Non-ST-Elevation Myocardial Infarction [FAST-MI]). Am J Cardiol 2013; 111: 31–37.
Kadoglou NP, Kottas G, Lampropoulos S, Vitta I, Liapis CD . Serum levels of fetuin-A, osteoprotegerin and osteopontin in patients with coronary artery disease: effects of statin (HMGCoA-reductase inhibitor) therapy. Clin Drug Invest 2014; 34: 165–171.
Sun Q, Cornelis MC, Manson JE, Hu FB . Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S. Diabetes 2013; 62: 49–55.
Schoppet M, Rauner M, Benner J, Chapurlat R, Hofbauer LC, Szulc P . Serum fetuin-A levels and abdominal aortic calcification in healthy men — The STRAMBOstudy. Bone 2015; 79: 196–202.
Karabakan M, Bozkurt A, Gunay M, Aktas BK, Hirik E, Aydın M et al. Association between serum fetuin-A level and erectile function. Andrologia 2015; 48: 787–792.
Yin L, Cai WJ, Zhu LY, Li J, Su XH, Wang XL et al. Association of plasma Fetuin-A and clinical characteristics in patients with new-onset type 2 diabetes mellitus. Int J. Clin Exp Med 2015; 8: 991–999.
Khalil H, Faizehalkuobaili . Elevated fetuin - A level associated with an atherogenic lipid profile in type 2 diabetes. Int J Pharm Sci 2013; 4: 266–269.
Mare'chal C, Schlieper G, Nguyen P, Kruger T, Coche E, Robert A et al. Serum fetuin-a levels are associated with vascular calcifications and predict cardiovascular events in renal transplant recipients. Clin J Am Soc Nephrol 2011; 6: 974–985.
Gulhan I, Bozkaya G, Oztekin D, Uyar I, Kebapcilar AG, Pamuk B . Serum Fetuin-A levels in women with polycystic ovary syndrome. Arch Gynecol Obstet 2012; 286: 1473–1476.
The authors declare no conflict of interest.
About this article
Cite this article
Kandeel, W., El-Shaer, W., Sebaey, A. et al. Usefulness of serum fetuin-A level as a marker of erectile dysfunction. Int J Impot Res 29, 189–193 (2017). https://doi.org/10.1038/ijir.2017.21