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Surgical treatment of Peyronie’s disease with small intestinal submucosa graft patch

International Journal of Impotence Research volume 28, pages 106–109 (2016)Cite this article

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Abstract

The objective of the study was to report our results using a porcine small intestinal submucosa graft (Surgisis ES, Cook Medical) for tunica albuginea substitution after plaque incision. We retrospectively evaluated patients surgically treated at our institution for Peyronie’s disease (PD) by means of plaque incision and porcine small intestinal submucosa grafting (Surgisis) between 2009 and 2013. At the same time a literature review was conducted, searching for similar reports and results. Forty-four patients were identified who had been diagnosed with PD between 2009 and the beginning of 2013, and had been treated with corporoplasty, plaque incision and grafting with Surgisis for a severe curvature of the penis. Curvature of the penis was dorsal in 40 patients (90%) and laterally on the right in 4 patients (10%). Mean duration of surgery was 165 min (range 90–200). Mean size of the graft was 6.5 cm2 and the mean follow-up was 19.2 months (range 11–48). In patients with severe curvature of the penis due to PD and the need for corporoplasty with plaque incision and graft placement, Surgisis represents a good option with a low risk of complications, below the rate described with previously investigated graft tissues.

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References

  1. Hauck EW, Weidner W . François de la Peyronie and the disease named after him. Lancet 2001; 357: 2049–2051.

    Article  CAS  Google Scholar 

  2. Gholami SS, Gonzalez-Cadavid NF, Lin CS, Rajfer J, Lue TF . Peyronie's disease: a review. J Urol 2003; 169: 1234–1241.

    Article  Google Scholar 

  3. Brock G, Hsu GL, Nunes L, von Heyden B, Lue TF . The anatomy of the tunica albuginea in the normal penis and Peyronie's disease. J Urol 1997; 157: 276–281.

    Article  CAS  Google Scholar 

  4. Devine CJ Jr, Somers KD, Jordan SG, Schlossberg SM . Proposal: trauma as the cause of the Peyronie's lesion. J Urol 1997; 157: 285–290.

    Article  Google Scholar 

  5. Devine CJ Jr, Somers KD, Ladaga LE . Peyronie's disease: pathophysiology. Prog Clin Biol Res 1991; 370: 355–358.

    PubMed  Google Scholar 

  6. Mulhall JP . Expanding the paradigm for plaque development in Peyronie's disease. Int J Impot Res 2003; 15: S93–102.

    Article  Google Scholar 

  7. Nesbit R . Congenital curvature of the phallus: report of three cases with description of corrective operation. J Urol 1965; 93: 230–232.

    Article  CAS  Google Scholar 

  8. Bran OW, Bella AJ, Lue TF . 16-Dot procedure for penile curvature. J Sex Med 2007; 4: 277–280.

    Article  Google Scholar 

  9. Ralph DJ . The surgical treatment of Peyronie's disease. Eur Urol 2006; 50: 196–198.

    Article  Google Scholar 

  10. Kadioglu A, Akman T, Sanli O, Gurkan L, Cakan M, Celtik M . Surgical treatment of Peyronie's disease: a critical analysis. Eur Urol 2006; 50: 235–248.

    Article  Google Scholar 

  11. Levine LA, Lenting EL . A surgical algorithm for the treatment of Peyronie's disease. J Urol 1997; 158: 2149–2152.

    Article  CAS  Google Scholar 

  12. Knoll LD . Use of small intestinal submucosa graft for the surgical management of Peyronie's disease. J Urol 2007; 178: 2474–2478.

    Article  Google Scholar 

  13. Bokarica P, Parazajder J, Mazuran B, Gilja I . Surgical treatment of Peyronie’s disease based on penile length and degree of curvature. Int J Impot Res 2005; 17: 170–174.

    Article  CAS  Google Scholar 

  14. Levine LA, Cuzin B, Mark S, Gelbard MK, Jones NA, Liu G et al. Clinical safety and effectiveness of collagenase Clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study. J Sex Med 2014; 12: 248–258.

    Article  Google Scholar 

  15. Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL . Glycosaminoglycan content of small intestinal submucosa: a bioscaffold for tissue replacement. Tissue Eng 1996; 2: 209–217.

    Article  CAS  Google Scholar 

  16. McPherson TB, Badylack SF . Characterizations of fibronectin derived from porcine small intestinal submucosa. Tissue Eng 1998; 4: 75–86.

    Article  CAS  Google Scholar 

  17. McDevitt CA, Wildey GM, Cutrone RM . Transforming growth factor-beta1 in a sterilized tissue derived from the pig small intestine submucosa. J Biomed Mater Res A 2003; 67: 637–640.

    Article  Google Scholar 

  18. Dejardin LM, Arnoczky SP, Clarke RB . Use of small intestinal submucosal implants for regeneration of large fascial defects: an experimental study in dogs. J Biomed Mater Res 1999; 46: 203–211.

    Article  CAS  Google Scholar 

  19. Monga M, Cosgrove D, Zupkas P, Jain A, Kasyan A, Wilkes N et al. Small intestinal submucosa as a tunica albuginea graft material. J Urol 2002; 168: 1215–1221.

    Article  Google Scholar 

  20. Knoll LD . Use of porcine small intestinal submucosal graft in the surgical management of Peyronie's disease. Urology 2001; 57: 753–757.

    Article  CAS  Google Scholar 

  21. Flores S, Choi J, Alex B, Mulhall JP . Erectile dysfunction after plaque incision and grafting: short-term assessment of incidence and predictors. J Sex Med 2011; 8: 2031–2037.

    Article  Google Scholar 

  22. Staerman F, Pierrevelcin J, Ripert T, Menard J . Medium-term follow-up of plaque incision and porcine small intestinal submucosal grafting for Peyronie's disease. Int J Impot Res 2010; 22: 343–348.

    Article  CAS  Google Scholar 

  23. Breyer BN1, Brant WO, Garcia MM, Bella AJ, Lue TF . Complications of porcine small intestine submucosa graft for Peyronie's disease. J Urol 2007; 177: 589–591.

    Article  Google Scholar 

  24. Lee EW, Shindel AW, Brandes SB . Small intestinal submucosa for patch grafting after plaque incision in the treatment of Peyronie's disease. Int Braz J Urol 2008; 34: 191–196.

    Article  Google Scholar 

  25. Eltahawy EA, Virasoro R, McCammon KA, Schlossberg SM, Jordan GH . Management of Peyronie’s disease using dermal porcine small intestinal submucosa (SIS) grafts. J Urol Suppl 2006; 175: 321.

    Article  Google Scholar 

  26. Dalkin BL, Carter MF . Venogenic impotence following dermal graft repair for Peyronie’s disease. J Urol 1991; 146: 849–851.

    Article  CAS  Google Scholar 

  27. John T, Bandi G, Santucci R . Porcine small intestinal submucosa is not an ideal graft material for Peyronie's disease surgery. J Urol 2006; 176: 1025–1028.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Andrology Department, Fundació Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain

    M Cosentino, A Vives, J Sanchez, M F Peraza, D Moreno, E Ruiz-Castañe & J Sarquella

  2. Urology Department, Fundació Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain

    A Kanashiro

  3. Anesthesia Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain

    J Perona

  4. Urology Department, Ospedale Borgo Trento, Verona, Italy

    V De Marco

Authors
  1. M Cosentino
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  2. A Kanashiro
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  3. A Vives
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  4. J Sanchez
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  5. M F Peraza
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  6. D Moreno
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  7. J Perona
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  8. V De Marco
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  9. E Ruiz-Castañe
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  10. J Sarquella
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Correspondence to M Cosentino.

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Cosentino, M., Kanashiro, A., Vives, A. et al. Surgical treatment of Peyronie’s disease with small intestinal submucosa graft patch. Int J Impot Res 28, 106–109 (2016). https://doi.org/10.1038/ijir.2016.10

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  • DOI: https://doi.org/10.1038/ijir.2016.10

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