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Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

International Journal of Impotence Research volume 25, pages 45–50 (2013)Cite this article

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Abstract

Ginseng is beneficial for many aspects of human physiology, including sexual function. In this study, we have evaluated the efficacy and safety of an extract of ginseng berry, which has a ginsenoside profile distinct from other parts of the plant, on sexual function in men with erectile dysfunction. In all, 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study. They were administered 4 tablets of either standardized Korean ginseng berry (SKGB, 350 mg ginseng berry extract per tablet), or placebo, daily, for 8 weeks. Efficacy was assessed with the International Index of Erectile Function (IIEF)-15 and premature ejaculation diagnostic tool (PEDT) at the end of the 4th and 8th week. We observed that the total and each of the individual domain scores of IIEF-15 increased from 40.95±7.05 to 46.19±12.69 significantly in the SKGB by the 8th week (P<0.05). The erectile function domain of IIEF changed slightly from 17.17±2.57 to 18.59±5.99 in the SKGB group by the 8th week (P<0.05). In addition, PEDT scores significantly improved from 9.14±4.57 to 7.97±4.4 and 7.53±4.26 in the SKGB group after 4 and 8 weeks of treatment (P<0.05). Safety markers including hormone and lipid in the blood were assessed at the end of the 4th and 8th week and they remained unchanged. Oral administration of the SKGB extract improved all domains of sexual function. It can be used as an alternative medicine to improve sexual life in men with sexual dysfunction.

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References

  1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61.

    Article  CAS  PubMed  Google Scholar 

  2. Laumann EO, Nicolosi A, Glasser DB, Paik A, Gingell C, Moreira E et al. Sexual problems among women and men aged 40–80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005; 17: 39–57.

    Article  CAS  PubMed  Google Scholar 

  3. Moreira SG, Brannigan RE, Spitz A, Orejuela FJ, Lipshultz LI, Kim ED . Side-effect profile of Sildenafil Citrate (Viagra) in clinical practice. J Urol 2000; 56: 474–476.

    Article  Google Scholar 

  4. Ferguson JM . SSRI antidepressant medications: adverse effects and tolerability. Prim Care J Clin Psychiatry 2011; 3: 22–27.

    Article  Google Scholar 

  5. Nam KY . Clinical application and efficacy of Korean ginseng. J Ginseng Res 2002; 26: 111–131.

    Article  CAS  Google Scholar 

  6. The Korean Society of Ginseng. All about Korean Ginseng. The Korean Society of Ginseng: Seoul, 2008 pp 80–86.

  7. Attele AS, Wu JA, Yuan CS . Multiple pharmacological effects of ginseng. Biochem Pharmacol 1999; 58: 1685–1693.

    Article  CAS  PubMed  Google Scholar 

  8. Wang CZ, Zhang B, Song WX, Wang A, Ni M, Luo X et al. Steamed American ginseng berry: ginsenoside analyses and anticancer activities. J Agric Food Chem 2006; 54: 9936–9942.

    Article  CAS  PubMed  Google Scholar 

  9. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002; 51: 1851–1858.

    Article  CAS  PubMed  Google Scholar 

  10. Li Z, Niwa Y, Sakamoto S, Shono M, Chen X, Nakaya Y . Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells. Life Sci 2000; 67: 2983–2989.

    Article  CAS  PubMed  Google Scholar 

  11. Scott GI, Colligan PB, Ren BH, Ren J . Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide. Br J Pharmacol 2001; 134: 1159–1165.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kim ND, Kim EM, Kang KW, Cho MK, Choi SY, Kim SG . Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. Br J Pharmacol 2003; 140: 661–670.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bai CX, Takahashi C, Masumiya H, Sawanobori T, Furukawa T . Nitric oxide-dependent modulation of the delayed rectifier K+ current and the L-type Ca2+ current by ginsenoside Re, an ingredient of Panax ginseng, in guinea-pig cardiomyocytes. Br J Pharmacol 2004; 142: 567–575.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Wang X, Chu S, Qian T, Chen J, Zhang J . Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine moniphosphate pathway. J Sex Med 2010; 7: 743–750.

    Article  CAS  PubMed  Google Scholar 

  15. Kam SC, Han DH, Huh JH, Lee SW . Development and validation of a Korean version of the Premature Ejaculation Diagnostic Tool (PEDT). Korean J Androl 2009; 27: 439–444.

    Google Scholar 

  16. Chung TG, Lee TK, Chung S, Lee MS, Kim YS, Ahn TY . The Korean Version of the International Index of Erectile Function(IIEF): reliability and validation study. Korean J Urol 1999; 40: 1334–1343.

    Google Scholar 

  17. Angulo J, Peiro C, Sanchez-Ferrer CF, Gabancho S, Cuevas P, Gupta S et al. Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. Br J Pharmacol 2001; 134: 1190–1194.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH . Nitric oxide: a physiologic mediator of penile erection. Science 1992; 257: 401–403.

    Article  CAS  PubMed  Google Scholar 

  19. Garban H, Vernet D, Freedman A, Rajfer J, Gonzalez-Cadavid N . Effect of aging on nitric oxide-mediated penile erection in rats. Am J Physiol 1995; 268: H467–H475.

    CAS  PubMed  Google Scholar 

  20. De Andrade E, de Mesquita AA, de Almeida CJ, de Andrade PM, Ortiz V, Paranhos M et al. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction. Asian J Androl 2007; 9: 241–244.

    Article  PubMed  Google Scholar 

  21. Oh KJ, Chae MJ, Lee HS, Hong HD, Park KS . Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med 2010; 7: 1469–1477.

    Article  CAS  PubMed  Google Scholar 

  22. Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY et al. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian J Androl 2009; 11: 356–361.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E . Red ginseng for treating erectile dysfunction a systematic review. Br J Clin Pharmacol 2008; 66: 444–450.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Shamloul R . Natural aphrodisiacs. J Sex Med 2010; 7: 39–49.

    Article  PubMed  Google Scholar 

  25. Choi HK, Seong DH, Rha KH . Clinical efficacy of Korean red ginseng for erectile dysfunction. Int J Impot Res 1995; 7: 181–186.

    CAS  PubMed  Google Scholar 

  26. Hong B, Ji YH, Hong JH, Nam KIY, Ahn TY . A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002; 168: 2040–2073.

    Article  Google Scholar 

  27. Ho CCK, Tan HM . Rise of herbal and traditional medicine in erectile dysfunction management. Curr Urol Rep 2011; 12: 470–478.

    Article  PubMed  Google Scholar 

  28. Rosen RC, Allen KR, Ni X, Araujo AB . Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale. Eur Urol 2011; 60: 1010–1016.

    Article  PubMed  Google Scholar 

  29. Zenico T, Cicero AFG, Valmorri L, Mercuriali M, Bercovich E . Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial. Andrologia 2009; 41: 95–99.

    Article  CAS  PubMed  Google Scholar 

  30. Aoki H, Nagao J, Ueda T, Strong JM, Schonlau F, Song YJ et al. Clinical assessment of a supplement of Pycnogenol® and L-arginine in Japanese patients with mild to moderate erectile dysfunction. Phytother Res 2012; 26: 204–207.

    Article  CAS  PubMed  Google Scholar 

  31. Tharakan B, Manyam BV . Botanical therapies in sexual dysfunction. Phytother Res 2005; 19: 457–463.

    Article  PubMed  Google Scholar 

  32. Sung HH, Chae MR, So I, Jeon JH, Park JK, Lee SW . Effects of ginsenoside on large-conductance K(Ca) channels in human corporal smooth muscle cells. Int J Impot Res 2011; 23: 193–199.

    Article  CAS  PubMed  Google Scholar 

  33. Tachikawa E, Kudo K, Harada K, Kashimoto T, Miyate Y, Kakizaki A . Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol 1999; 369: 23–32.

    Article  CAS  PubMed  Google Scholar 

  34. Mehendale SR, Wang CZ, Shao ZH, Li CQ, Zie JT, Aung HH et al. Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant in cardiomyocytes. Eur J Pharrmacol 2006; 553: 209–214.

    Article  CAS  Google Scholar 

  35. Furukawa T, Bai CX, Kaihara A, Ozaki E, Kawano T, Nakaya Y et al. Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a nongenomic pathway of sex hormones. Mol Pharmacol 2006; 70: 1916–1924.

    Article  CAS  PubMed  Google Scholar 

  36. Tsang D, Yeung HW, Tso WW, Peck H . Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 1985; 51: 221–224.

    Article  Google Scholar 

  37. D’Angelo L, Grimaldi R, Caravaggi M . A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 1986; 16: 15–22.

    Article  PubMed  Google Scholar 

  38. Spector IP, Carey MP . Incidence and prevalence of sexual dysfunctions: a critical review of the empirical literature. Arch Sex Behav 1990; 19: 389–408.

    Article  CAS  PubMed  Google Scholar 

  39. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4 edn, text revision (DSM-IV-TR). American Psychiatric Association: Washington, DC, 2000 pp 552–554.

  40. McMahon CG, McMahon CN, Liang JL, Winestock CG . Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: a systematic review. BJU Int 2006; 98: 259–272.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A084120) and Amorepacific.

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Authors and Affiliations

  1. Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, South Korea

    Y D Choi

  2. R&D Center, Amorepacific Corporation, Gyeonggi-do, South Korea

    C W Park, J Jang, S H Kim, H Y Jeon, W G Kim & S J Lee

  3. Department of Urology, Urology Department EU Mok-dong Hospital, Ewha Womans University School of Medicine, 911-1 Mok-dong, Yangcheon-ku, Seoul, 158-710, South Korea

    W S Chung

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  1. Y D Choi
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Correspondence to W S Chung.

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Choi, Y., Park, C., Jang, J. et al. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study. Int J Impot Res 25, 45–50 (2013). https://doi.org/10.1038/ijir.2012.45

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Keywords

  • ejaculation
  • erection
  • ginseng berry
  • sexual function

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