Original Article | Published:

The association between Peyronie's and Dupuytren's disease

International Journal of Impotence Research volume 23, pages 142145 (2011) | Download Citation


Peyronie's disease (PD) is known to be associated with Dupuytren's disease (DD) since 1828. The aim of this study was to investigate the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics. From January 1988 to December 2009 all patients, presenting at our outpatient urological clinic, with PD were also examined for DD. The sample consisted of 415 male subjects with PD, 89 (22.1%) also had DD. A total of 28 men (6.7%) reported to have one or more first or second degree relatives with DD.


Peyronie's disease (PD) is a localized, connective tissue disorder characterized by the formation of fibrous tissue plaques within the tunica albuginea of the penis, causing a penile deformity, and a subsequent degree of erectile dysfunction and penile pain. Although its etiology has not been elucidated, PD probably results from the presence of a predisposing genetic susceptibility combined with a trauma to the erect penis.1, 2 PD appears to be more common in northern European Caucasians; its uncommon in African-American men and very rare in Asians.3 Diabetes mellitus also seem to be a potential risk factor for PD.4

The very first cross-sectional study giving the proposed incidence and prevalence rates of PD was published in 1991 by investigators from Minnesota, USA.5 The reported prevalence rate of 0.38% was consistent with earlier reports. It was estimated that there were more than 423 000 men with PD in the USA at that time and that 32 000 new cases occurred annually. Mean patient age at diagnosis was 53 years (range 19–83). The first PD prevalence rates to be reported in a European cross-sectional study came from Germany. In a survey of 4432 men (aged 30–80 years) in Cologne, 3.2% reported a palpable plaque in the penis.4 It is now believed that the actual prevalence rate may be closer to 8% or higher.6 The true prevalence rate of PD may be even higher than that of Dupuytren's disease (DD) because men are likely to underreport a condition that causes embarrassment.

The association between PD and DD was first recognized in 1828 and reported by Abernathy.7 According to the literature there is a 3–15% chance that a man with DD will have PD.8, 9, 10 DD is a fibro-proliferative condition of the palmar fascias in the hand, typically resulting in progressive contracture of one or more fingers.11 DD is thought to be the most common hereditary connective tissue disorder in Caucasians.12 The prevalence of DD in different geographical locations is extremely variable (0.2–56%), and its not clear whether this is genetic, environmental or a combination of both. Population structure, the prevalence of associated diseases and the diagnostic criteria of DD, makes the understanding of epidemiology quite difficult.13 The literature concerning coexisting DD in patients presenting with PD shows wide ranges varying from 0.01 to 58.8%.5, 9, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24

The aim of this study is to investigate the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics, presenting at the outpatient urological clinic of the University Medical Centre Groningen, The Netherlands.

Patients and methods

From January 1988 to December 2009 all patients presenting with PD were examined on DD by one of the investigators (MFvD). The investigator checked both hands for nodules and finger contractures. The diagnosis PD was made by history and examination, that is, the presence of a palpable plaque in the penis. The investigator measured the size of the plaque using a ruler and noted the size, together with the location of the plaque, in the patients' chart. The direction and severity of the curvature were based on homemade photographs. All patients were asked for the presence of pain, a decreased rigidity and problems with intercourse. The patients were also asked for a positive family history for PD and DD.


The sample consisted of 415 Caucasian male subjects with PD. The mean age of the patients was 60±12 years and the mean duration of the disease was 18±29 months. A total of 252 patients (60.7%) were referred by their general practitioner, 99 (24.0%) by another urologist and 30 (7.2%) by other medical specialties. A total of 89 of the patients (22.1%) also had DD. In 13 patients (3.1%) there was no information about the presence of DD (Table 1).

Table 1: Clinical characteristics of the study population (415 men)

A total of 28 patients (6.7%) reported to have one or more close relatives (mother, father, brother, sister or grandmother) with DD. Five patients reported to have a father and two patients reported to have a brother with PD.

At the first visit 171 patients (44.9%) experienced a decreased rigidity at erection and 124 patients (34.1%) had pain during erection. A dorsal curvature was present in 238 patients (57.3%) and a ventral curvature in 31 patients (7.5%). There was a problem with intromission of the penis in the vagina in 214 patients (59.6%), problems with coital-movements occurred in 118 patients (33.3%) and 53 (16.8%) of the partners experienced pain during intercourse.

In all 93 patients (22.4%) underwent surgery; a penoplication according to Nesbitt (n=88) or plaque excision or incision with grafting (n=5). Twelve patients (12.9%) reported a complication or an uneventful outcome; erectile dysfunction (n=3), curvature recurrence (n=3), wound infection (n=2), paraphimosis (n=1), urethral stricture due to circumcision (n=1), skin surplus after circumcision (n=1) and anorgasmia (n=1).


In order to evaluate the coexistence of DD in patients with PD, 415 consecutive patients were examined. This study is the largest series, which examined the coexistence of DD in patients with PD. In 22% both diseases were present. Previous reports concerning coexisting DD in patients presenting with PD show ranges varying from 0.01 to 58.8%, a positive family history for PD in 1–4% and a positive family history for DD in 9.8% (Table 2).5, 9, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 The series from the UK, Italy, Australia and Serbia show the highest percentage of PD patients with coexisting DD.9, 15, 17, 19, 24 The two reports focusing on PD patients <40 years show a lower percentage of coexisting DD.21, 23 Only Williams and Thomas15 specified their method of finding DD in PD patients. Twenty-five had a follow-up period of 2 months up to 13 years. Seventeen of them were examined particularly for ‘Dupuytren's contracture’ in view of the known incidence with PD. Eventually, DD was diagnosed in 10 patients.

Table 2: Studies on Dupuytren's disease in patients with Peyronie's disease

The wide variation of patients with PD having coexisting DD may have several reasons. First, the gene expression profiles of DD and PD may differ throughout the world. Second, in some articles the authors clearly discuss about ‘Dupuytren's contracture’ and not about DD. Patients with discrete nodules in their hands may not be diagnosed as DD and one may presume that not in all series patients have been examined by an experienced clinician. The third explanation for the wide spread may be the examination of different age groups, because the risk of acquiring PD as well as DD increases with advancing age. A Turkish study showed that out of 231 men with PD, only 8.2% presented under the age of 40.25 A comparable percentage (9.9%) was also observed in the Minnesota study.5

Hindocha et al. report a mean age of onset in familial DD of 49 years and 55 in non-familial DD.13 This may explain the very low percentage of coexisting DD in the study by Levine et al.21 Finally, the varying or unknown follow-up periods in the different studies may explain the wide ranges of coexisting DD in PD.

In 1982, Nyberg et al.10 documented the familial transmission of PD as an autosomal dominant trait in three pedigrees. The occurrence of DD in seven of their nine (78%) affected individuals, which was a significant increase over the average 0% reported in sporadic cases, suggested that both of these fibrosing disorders should be pleiotropic effects of the same genes in these families. Similarly, the histocompatibility B7 cross-reacting antigens were present in 90% of their PD patients.

Ziegelbaum et al.26 reported on identical twins with PD and the HLA-B40 antigen. Family studies were also undertaken by Bias et al.27 when three patients reported similarly affected first-degree relatives. One kindred showed father-to-son transmission of PD with DD in three generations. Pedigree analysis of the three families suggested that PD also is a male-limited, autosomal dominant trait. Antigens of the HLA-B7 cross-reacting group occurred in all three kindreds; however, the data ruled out close linkage of the disease and HLA.


DD is thought to be the most common hereditary connective tissue disorder in Caucasians. However, the true prevalence rate of PD may be even higher than that of DD due to the fact that men are likely to underreport a condition that causes embarrassment. This single-center study in Dutch PD patients showed coexisting DD in 20%. Given the increased recognition of PD, as well as the emerging treatment, which is currently being used for DD and may become approved worldwide for PD (collagenase), the association between these two disorders will gain greater importance.


  1. 1.

    , , . Pharmacological management of Peyronie's disease. Drugs 2007; 67: 527–545.

  2. 2.

    , . The management of Peyronie's disease. BJU Int 2004; 93: 208–215.

  3. 3.

    , , , . Racial considerations in the evaluation of Peyronie's disease. J Urol 2001; 165170: 687A.

  4. 4.

    , , , , , et al. Epidemiology of Peyronie's disease. Int J Impot Res 2002; 14: 379–383.

  5. 5.

    , , , , , . The incidence of Peyronie's disease in Rochester, Minnesota, 1950 through 1984. J Urol 1991; 146: 1007–1009.

  6. 6.

    , . Peyronie's disease: etiology, epidemiology and medical treatment. Urol Clin N Am 2005; 32: 469–478.

  7. 7.

    . The Consequences of Gonorrhea. Lecture on Anatomy, Surgery and Pathology: Including Observations on the Nature and Treatment of Local Diseases, Delivered at St Bartholomew's and Christ's Hospitals. 1st edn. James Balcock: London (England), 1828 pp. 205.

  8. 8.

    . The genetic factor in Dupuytren's disease. J Bone Joint Surg 1963; 45: 709.

  9. 9.

    , , , , , . The genetic and bacteriological aspects of Peyronie's disease. J Urol 1997; 157: 291–294.

  10. 10.

    , , , . Identification of an inherited form of Peyronie's disease with autosomal dominant inheritance and association with Dupuytren's contracture and histocompatibility B7 cross-reacting antigens. J Urol 1982; 128: 48–51.

  11. 11.

    , , , , , et al. Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells. Exp Cell Res 2009; 315: 3574–3586.

  12. 12.

    , , , , . The heritability of Dupuytren's disease: familial aggregation and its clinical significance. J Hand Surg 2006; 31: 204–210.

  13. 13.

    , , . Epidemiological evaluation of Dupuytren's disease: incidence and prevalence rates in relation to etiology. Hand 2009; 4: 256–269.

  14. 14.

    . Peyronie's disease. Am J Clin Pathol 1966; 45: 670–678.

  15. 15.

    , . The natural history of Peyronie's disease. Proc Roy Soc Med 1968; 61: 876.

  16. 16.

    , , , . Factors associated in the aetiology of Peyronie's disease. Br J Urol Int 1982; 54: 748–750.

  17. 17.

    , , , , . A case-control study on risk factors for Peyronie's disease. J Clin Epidemiology 1998; 51: 511–515.

  18. 18.

    , , , , . Peyronie's disease: epidemiology and clinical presentation of 134 cases. Int Urol Nephrol 2001; 32: 691–694.

  19. 19.

    , , . The incidence, aetiology, and presentation of Peyronie's disease in Sydney, Australia. J Sex Disability 2002; 20: 109–116.

  20. 20.

    , , , , , . A retrospective review of 307 men with Peyronie's disease. J Urol 2002; 168: 1075–1079.

  21. 21.

    , , , . Peyronie's disease in younger men: characteristics and treatment Results. J Androl 2003; 24: 27–32.

  22. 22.

    , , , . Risk factors for Peyronie's disease: a case-control study. B J Urol Int 2006; 97: 570–574.

  23. 23.

    , , , , , . Defining the clinical characteristics of Peyronie's disease in young men. J Sex Med 2007; 4: 485–490.

  24. 24.

    , , , , . A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie's disease. J Sex Med 2010; 7: 1529–1537.

  25. 25.

    , , , , , . Peyronie's disease in men under age 40: L characteristics and outcome. Int J Impot Res 2001; 13: 18–23.

  26. 26.

    , , . The association of Peyronie's disease with HLA B7 cross-reacting antigens. A case report of identical twins. Cleve Clin J Med 1987; 54: 427.

  27. 27.

    , , , . Peyronie's disease: a newly recognized autosomal-dominant trait. Am J Med Genet 1982; 12: 227–235.

Download references

Author information


  1. Department of Urology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    • H M Nugteren
    • , J M Nijman
    • , I J de Jong
    •  & M F van Driel


  1. Search for H M Nugteren in:

  2. Search for J M Nijman in:

  3. Search for I J de Jong in:

  4. Search for M F van Driel in:

Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to H M Nugteren.

About this article

Publication history







Further reading