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Effects of sildenafil and vardenafil treatments on sleep quality and depression in hemodialysis patients with erectile dysfunction

International Journal of Impotence Research volume 23, pages 27–31 (2011)Cite this article

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Abstract

ED is prevalent in hemodialysis (HD) patients, and closely related to poor sleep and depression. Efficacy of treating ED either with sildenafil or vardenafil has been shown to be beneficial in ameliorating concomitant depression in non-HD patients. It is yet to be shown whether treatment of ED with a PDE-5 inhibitor would improve poor sleep in HD patients. We aimed to compare the effects of sildenafil and vardenafil on sleep quality and depression in HD patients with ED. A total of 32 maintenance HD patients with ED randomized into two groups to receive either sildenafil or vardenafil for 4 weeks. After a 2-week washout and a crossover, each group received the other drug for another 4-week period. Sleep quality and depression were evaluated via post-sleep inventory (PSI) and Beck's depression inventory (BDI), respectively, at baseline and at the end of the treatment. Sildenafil and vardenafil both improved PSI and BDI scores significantly compared with pretreatment values. However, there was no difference between sildenafil and vardenafil with respect to these parameters. PDE-5 inhibitors, sildenafil and vardenafil, caused a significant improvement in sleep quality and depression in this cohort of HD patients with ED.

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References

  1. Turk S, Karalezli G, Tonbul HZ, Yildiz M, Altintepe L, Yildiz A et al. Erectile dysfunction and the effects of sildenafil treatment in patients on hemodialysis and continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant 2001; 16: 1818–1822.

    Article  CAS  Google Scholar 

  2. Padma-Nathan H . Sildenafil citrate (Viagra) treatment for erectile dysfunction: an updated profile of response and effectiveness. Int J Impot Res 2006; 18: 423–431.

    Article  CAS  Google Scholar 

  3. Sahin Y, Aygün C, Peþkircio∂lu CL, Kut A, Tekin MI, Ozdemir FN et al. Efficacy and safety of sildenafil citrate in hemodialysis patients. Transplant Proc 2004; 36: 56–58.

    Article  CAS  Google Scholar 

  4. Carson CC, Hatzichristou DG, Carrier S, Lording D, Lyngdorf P, Aliotta P et al. Patient Response with Vardenafil in Slidenafil Non-Responders (PROVEN) Study Group. Erectile response with vardenafil in sildenafil nonresponders: a multicentre, double-blind, 12-week, flexible-dose, placebo-controlled erectile dysfunction clinical trial. BJU Int 2004; 94: 1301–1309.

    Article  CAS  Google Scholar 

  5. Araujo AB, Durante R, Feldman HA, Goldstein I, McKinlay JB . The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med 1998; 60: 458–465.

    Article  CAS  Google Scholar 

  6. Herman JB, Brotman AW, Pollack MH, Falk WE, Biederman J, Rosenbaum JF . Fluoxetine-induced sexual dysfunction. J Clin Psychiatry 1990; 51: 25–27.

    CAS  PubMed  Google Scholar 

  7. Seidman SN, Roose SP, Menza MA, Shabsigh R, Rosen RC . Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate. Am J Psychiatry 2001; 158: 1623–1630.

    Article  CAS  Google Scholar 

  8. Rosen R, Shabsigh R, Berber M, Assalian P, Menza M, Rodriguez-Vela L et al. Vardenafil Study Site Investigators. Efficacy and tolerability of vardenafil in men with mild depression and erectile dysfunction: the depression-related improvement with vardenafil for erectile response study. Am J Psychiatry 2006; 163: 79–87.

    Article  Google Scholar 

  9. Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer MA et al. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant 2003; 18: 126–132.

    Article  Google Scholar 

  10. Jankowski JT, Seftel AD, Strohl KP . Erectile dysfunction and sleep related disorders. J Urol 2008; 179: 837–841.

    Article  Google Scholar 

  11. Turk S, Solak Y, Kan S, Atalay H, Kilinc M, Agca E et al. Effects of sildenafil and vardenafil on erectile dysfunction and health-related quality of life in haemodialysis patients: a prospective randomized crossover study. Nephrol Dial Transplant 2010; 25: 3729–3733.

    Article  CAS  Google Scholar 

  12. Cappelleri JC, Rosen RC . The Sexual Health Inventory for Men (SHIM): a 5-year review of research and clinical experience. Int J Impot Res 2005; 17: 307–319.

    Article  CAS  Google Scholar 

  13. Beck AT, Guth D, Steer RA, Ball R . Screening for major depression disorders in medical inpatients with the Beck Depression Inventory for Primary Care. Behav Res Ther 1997; 35: 785–791.

    Article  CAS  Google Scholar 

  14. Hisli N . Beck Depresyon Envanteri’nin geçerliligi üzerine bir çalisma. Psikoloji Dergisi 1998; 6: 118–122.

    Google Scholar 

  15. Webb WB, Bonnet M, Blume G . A post-sleep inventory. Percept Mot Skills 1976; 43: 987–993.

    Article  Google Scholar 

  16. Uzun S, Kara B, Iscan B . Hemodiyalize giren kronik böbrek yetmezli∂i olan hastalarda uyku sorunlarỳ. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 2003; 2: 61–66.

    Google Scholar 

  17. Veiga J, Goncalves N, Gomes F, Santos N, Babtista A, Paiva T . Sleep disturbances in end-stage renal disease patients on hemodialysis. Dial Transplant 1997; 26: 380–384.

    Google Scholar 

  18. Turk S, Atalay H, Altintepe L, Güney I, Okudan N, Tonbul HZ et al. Treatment with antidepressive drugs improved quality of life in chronic hemodialysis patients. Clin Nephrol 2006; 65: 113–118.

    Article  CAS  Google Scholar 

  19. Finkelstein FO, Wuerth D, Troidle LK, Finkelstein SH . Depression and end-stage renal disease: a therapeutic challenge. Kidney Int 2008; 74: 843–845.

    Article  Google Scholar 

  20. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61.

    Article  CAS  Google Scholar 

  21. Gusbeth-Tatomir P, Boisteanu D, Seica A, Buga C, Covic A . Sleep disorders: a systematic review of an emerging major clinical issue in renal patients. Int Urol Nephrol 2007; 39: 1217–1226.

    Article  Google Scholar 

  22. Tsuno N, Besset A, Ritchie K . Sleep and depression. J Clin Psychiatry 2005; 66: 1254–1269.

    Article  Google Scholar 

  23. Teloken PE, Smith EB, Lodowsky C, Freedom T, Mulhall JP . Defining association between sleep apnea syndrome and erectile dysfunction. Urology 2006; 67: 1033–1037.

    Article  Google Scholar 

  24. Jankowski JT, Seftel AD, Strohl KP . Erectile dysfunction and sleep related disorders. J Urol 2008; 179: 837–841.

    Article  Google Scholar 

  25. Gonçalves MA, Guilleminault C, Ramos E, Palha A, Paiva T . Erectile dysfunction, obstructive sleep apnea syndrome and nasal CPAP treatment. Sleep Med 2005; 6: 333–339.

    Article  Google Scholar 

  26. Taskin U, Yigit O, Acioglu E, Aricigil M, Toktas G, Guzelhan Y . Erectile dysfunction in severe sleep apnea patients and response to CPAP. Int J Impot Res 2010; 22: 134–139.

    Article  CAS  Google Scholar 

  27. Margel D, Cohen M, Livne PM, Pillar G . Severe, but not mild, obstructive sleep apnea syndrome is associated with erectile dysfunction. Urology 2004; 63: 545–549.

    Article  Google Scholar 

  28. Perimenis P, Konstantinopoulos A, Karkoulias K, Markou S, Perimeni P, Spyropoulos K . Sildenafil combined with continuous positive airway pressure for treatment of erectile dysfunction in men with obstructive sleep apnea. Int Urol Nephrol 2007; 39: 547–552.

    Article  Google Scholar 

  29. Roizenblatt S, Guilleminault C, Poyares D, Cintra F, Kauati A, Tufik S . A double-blind, placebo-controlled, crossover study of sildenafil in obstructive sleep apnea. Arch Intern Med 2006; 166: 1763–1767.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Meram School of Medicine, Selcuk University, Konya, Turkey

    Y Solak, H Atalay, M Yeksan & S Turk

  2. Department of Internal Medicine, Meram School of Medicine, Selcuk University, Konya, Turkey

    S Kan

  3. Department of Urology, Meram School of Medicine, Selcuk University, Konya, Turkey

    M Kaynar

  4. Department of Public Health, Meram School of Medicine, Selcuk University, Konya, Turkey

    S Bodur

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  1. Y Solak
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Correspondence to Y Solak.

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Solak, Y., Atalay, H., Kan, S. et al. Effects of sildenafil and vardenafil treatments on sleep quality and depression in hemodialysis patients with erectile dysfunction. Int J Impot Res 23, 27–31 (2011). https://doi.org/10.1038/ijir.2010.32

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  • DOI: https://doi.org/10.1038/ijir.2010.32

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