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Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials


Certain foods or their components are widely used in the prevention and/or management of cardiovascular disease. Milk proteins have been suggested to have hypotensive properties. A number of clinical trials have been carried out to evaluate the effect of milk proteins from whole foods and supplements on blood pressure (BP). However, the effect of milk proteins on BP is not well understood. Therefore, we conducted a meta-analysis of randomized control trials to provide insight into and robust evidence concerning the overall impact of milk proteins on BP. The PubMed and Cochrane databases were searched for literature concerning the effects of milk proteins on BP up to May 2016. A random effects model was used to calculate the pooled estimates and 95% confidence intervals of effect sizes. The final analysis included seven randomized control trials involving 412 participants. Overall, milk protein interventions significantly lowered systolic BP by −3.33 mm Hg (95% confidence interval −5.62, −1.03) and diastolic BP by −1.08 mm Hg (95% confidence interval −3.38, −0.22). There was no statistical evidence of publication bias across the studies. In conclusion, this meta-analysis provides further evidence that milk proteins slightly but significantly lower both systolic and diastolic BP.

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The study was supported by grants from the National Natural Science Foundation of China (no. 81472974 and no. 81273067) and from the Food and Drug Administration of Hebei province 2015 annual food and drug safety science and technology project plan (ZD2015019).

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Corresponding authors

Correspondence to Zeng-Ning Li or Li-Qiang Qin.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on Hypertension Research website

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Hidayat, K., Du, HZ., Yang, J. et al. Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials. Hypertens Res 40, 264–270 (2017).

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  • blood pressure
  • meta-analysis
  • milk protein
  • randomized control trial

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