Table 2 Comparison of clinical parameters and humoral factors before and after 6 months of combination treatment

From: Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension

  CCB combination Diuretic combination
Parameters Before 6 months Before 6 months
Total cholesterol (mg per 100 ml) 210±46 191±34* 222±38 203±34*
Triglycerides (mg per 100 ml) 120±62 113±64 114±55 126±65
HDL-cholesterol (mg per 100 ml) 49±13 51±13 54±12 49±12**
Fasting blood sugar (mg per 100 ml) 87±8 89±11 95±12 97±13
Serum potassium (mEq l−1) 4.07±0.46 4.09±0.34 4.11±0.44 4.18±0.32
Serum creatinine (mg per 100 ml) 0.90±0.28 0.87±0.23 0.79±0.20 0.85±0.25*
eGFR (ml min−1 per 1.73 m2) 60.2±13.8 62.0±14.1 68.5±14.3 64.0±14.5*
Urinary albumin/creatinine ratio (mg g−1) 83.3±220.2 43.6±67.5 41.0±52.4 16.3±26.3**
Serum uric acid (mg per 100 ml) 5.65±1.46 5.65±1.31 5.20±1.63 5.54±1.36
PRA (ng ml−1 per h) 1.19±1.6 2.29±3.36* 1.21±0.66 2.42±2.50*
Plasma aldosterone (pg ml−1) 92±49 72±34* 92±47 68±26*
BNP (pg ml−1) 32.7±33.0 35.8±26.4 42.7±45.9 60.8±123.2
  1. Abbreviations: BNP, brain natriuretic peptide; CCB, calcium channel blocker; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; PRA, plasma renin activity.
  2. *P<0.05, **P<0.01, vs. values before combination treatment.