Original Article | Published:

Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial

Hypertension Research volume 31, pages 15831588 (2008) | Download Citation

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Abstract

The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were −5.55 mmHg (95% confidence interval [CI], −10.5 to −0.57 mmHg; p <0.05) and −2.84 mmHg (CI, −5.33 to −0.33 mmHg; p >0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was −1.17 ng/mL/h for the nattokinase group compared with the control group (p <0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

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Author information

Affiliations

  1. Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea

    • Ji Young Kim
    • , Kyong-chol Kim
    • , Yangsoo Jang
    •  & Jong Ho Lee
  2. National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Seoul, Korea

    • Ji Young Kim
    • , Si Nae Gum
    • , Jean Kyung Paik
    • , Hyo Hee Lim
    •  & Jong Ho Lee
  3. Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea

    • Si Nae Gum
    • , Hyo Hee Lim
    •  & Jong Ho Lee
  4. Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul, Korea

    • Jean Kyung Paik
    •  & Jong Ho Lee
  5. Seoul Fellowship, Seoul, Korea

    • Jean Kyung Paik
  6. Department of Family Medicine, Mizmedi Hospital, Seoul, Korea

    • Kyong-chol Kim
  7. Japan Bio Science Laboratory Co., Ltd., Ibaraki, Osaka, Japan

    • Kazuya Ogasawara
    •  & Kenichi Inoue
  8. Cardiology Division, Yonsei University College of Medicine, Yonsei Cardiovascular Center, Seoul, Korea

    • Sungha Park
    •  & Yangsoo Jang
  9. Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, Korea

    • Yangsoo Jang

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Correspondence to Jong Ho Lee.

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DOI

https://doi.org/10.1291/hypres.31.1583