Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial


The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were −5.55 mmHg (95% confidence interval [CI], −10.5 to −0.57 mmHg; p <0.05) and −2.84 mmHg (CI, −5.33 to −0.33 mmHg; p >0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was −1.17 ng/mL/h for the nattokinase group compared with the control group (p <0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.


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Correspondence to Jong Ho Lee.

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Kim, J., Gum, S., Paik, J. et al. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertens Res 31, 1583–1588 (2008). https://doi.org/10.1291/hypres.31.1583

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  • nattokinase
  • blood pressure
  • renin activity
  • randomized
  • controlled trial

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