Abstract
Few population studies have addressed the association of QT interval prolongation with clinical or subclinical arterial disease. The primary objective here was to examine the relationship between the pulse wave velocity (PWV) and the heart rate–corrected QT interval duration (QTc). This is a cross-sectional study, based on a survey of a general population of Japanese. We examined 2,666 community-dwelling individuals without history of cardiovascular disease, aged 40 or over. The PWV was measured between the brachial and ankle regions (baPWV). QTc was estimated using Bazett's equation. The age-adjusted mean values of QTc increased progressively with rising baPWV levels for either sex: for men, 397, 401, 403, and 406 ms for quartile groups defined by baPWV values of less than 1,369, 1,370 to 1,560, 1,561 to 1,840, and 1,841 or greater cm/s, respectively (p<0.0001 for trend); for women, 406, 410, 414, and 417 ms for quartile groups defined by baPWV of less than 1,269, 1,270 to 1,493, 1,494 to 1,821, and 1,822 or greater cm/s, respectively (p<0.0001 for trend). When male and female subjects were combined, this positive relationship between baPWV and QTc remained significant, even after controlling for age, sex, hypertension, ECG abnormalities, dyslipidemia, diabetes, obesity, serum calcium and potassium, alcohol intake, and smoking habits (p<0.0001 for trend). In conclusion, baPWV is independently associated with QT interval prolongation.
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Lepeschkin E, Surawicz B : The measurement of the Q-T interval of the electrocardiogram. Circulation 1952; 6: 378–388.
Al-Khatib SM, LaPointe NM, Kramer JM, Califf RM : What clinicians should know about the QT interval. JAMA 2003; 289: 2120–2127.
Ewing DJ, Boland O, Neilson JM, Cho CG, Clarke BF : Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients. Diabetologia 1991; 34: 182–185.
Tomassoni G, Pisano E, Gardner L, Krucoff MW, Natale A : QT prolongation and dispersion in myocardial ischemia and infarction. J Electrocardiol 1998; 30 ( Suppl): 187–190.
Dekker JM, Schouten EG, Klootwijk P, Pool J, Kromhout D : Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study. Circulation 1994; 90: 779–785.
Dekker JM, Crow RS, Hannan PJ, Schouten EG, Folsom AR : Heart rate–corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. J Am Coll Cardiol 2004; 43: 565–571.
de Bruyne MC, Hoes AW, Kors JA, Hofman A, van Bemmel JH, Grobbee DE : Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study. Eur Heart J 1999; 20: 278–284.
Robbins J, Nelson JC, Rautaharju PM, Gottdiener JS : The association between the length of the QT interval and mortality in the Cardiovascular Health Study. Am J Med 2003; 115: 689–694.
Okin PM, Devereux RB, Howard BV, Fabsitz RR, Lee ET, Welty TK : Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: the Strong Heart Study. Circulation 2000; 101: 61–66.
Strohmer B, Pichler M, Iglseder B, Paulweber B : Relationship of QT interval duration with carotid intima media thickness in a clinically healthy population undergoing cardiovascular risk screening. J Intern Med 2005; 257: 238–246.
Festa A, D'Agostino R Jr, Rautaharju P, et al: QT interval a marker of subclinical atherosclerosis in nondiabetic subjects? The Insulin Resistance Atherosclerosis Study (IRAS). Stroke 1999; 30: 1566–1571.
Takebayashi K, Aso Y, Matsutomo R, Wakabayashi S, Inukai T : Association between the corrected QT intervals and combined intimal-medial thickness of the carotid artery in patients with type 2 diabetes. Metabolism 2004; 53: 1152–1157.
Nichols WW : Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertens 2005; 18: 3S–10S.
Sawabe M, Takahashi R, Matsushita S, et al: Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: a pathological study based on 304 autopsy cases. Atherosclerosis 2005; 179: 345–351.
Sugawara J, Hayashi K, Yokoi T, et al: Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens 2005; 19: 401–406.
Yamashina A, Tomiyama H, Takeda K, et al: Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002; 25: 359–364.
Arima H, Tanizaki Y, Kiyohara Y, et al: Validity of the JNC VI recommendations for the management of hypertension in a general population of Japanese elderly: the Hisayama study. Arch Intern Med 2003; 163: 361–366.
Bazett HC : An analysis of time relations of the electrocardiogram. Heart 1920; 7: 353–370.
Kobayashi K, Akishita M, Yu W, Hashimoto M, Ohni M, Toba K : Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity. Atherosclerosis 2004; 173: 13–18.
The Expert Committee on the Diagnosis and Classification: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183–1197.
Tomiyama H, Yamashina A, Arai T, et al: Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 2003; 166: 303–309.
Oikarinen L, Nieminen MS, Viitasalo M, et al: QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 2004; 43: 1029–1034.
Westerhof N, O'Rourke MF : Haemodynamic basis for the development of left ventricular failure in systolic hypertension and for its logical therapy. J Hypertens 1995; 13: 943–952.
Watabe D, Hashimoto J, Hatanaka R, et al: Electrocardiographic left ventricular hypertrophy and arterial stiffness: the Ohasama study. Am J Hypertens 2006; 19: 1199–1205.
Watanabe H, Ohtsuka S, Kakihana M, Sugishita Y : Coronary circulation in dogs with an experimental decrease in aortic compliance. J Am Coll Cardiol 1993; 21: 1497–1506.
Skinner J : Guidelines for the Diagnosis and Management of Familial Long QT Syndrome. Heart Lung Circ 2007; 16: 22–24.
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Maebuchi, D., Arima, H., Ninomiya, T. et al. Arterial Stiffness and QT Interval Prolongation in a General Population: The Hisayama Study. Hypertens Res 31, 1339–1345 (2008). https://doi.org/10.1291/hypres.31.1339
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DOI: https://doi.org/10.1291/hypres.31.1339
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