Antihypertensive Effect of Green Coffee Bean Extract on Mildly Hypertensive Subjects


A water-soluble green coffee bean extract (GCE) has been shown to be effective against hypertension in both spontaneously hypertensive rats and humans. This multicenter, randomized, double-blind, placebo-controlled, parallel group study evaluated the dose-response relationship of GCE in 117 male volunteers with mild hypertension. Subjects were randomized into four groups: a placebo and three drug groups that received 46 mg, 93 mg, or 185 mg of GCE once a day. After 28 days, systolic blood pressure (SBP) in the placebo, 46 mg, 93 mg, and 185 mg groups was reduced by −1.3±3.0 mmHg, −3.2±4.6 mmHg, −4.7±4.5 mmHg, and −5.6±4.2 mmHg from the baseline, respectively. The decreases in SBP in the 93 mg group (p<0.05) and the 185 mg group (p<0.01) were statistically significant compared with the placebo group. Diastolic blood pressure (DBP) in the placebo, 46 mg, 93 mg, and 185 mg groups was reduced by −0.8±3.1 mmHg, −2.9±2.9 mmHg, −3.2±3.2 mmHg, and −3.9±2.8 mmHg from the baseline, respectively, and significant effects were observed in the 93 mg group (p<0.05) and the 185 mg group (p<0.01) compared with the placebo group. Both blood pressures were significantly reduced in a dose-related manner by GCE (p<0.001). Adverse effects caused by GCE were not observed. The results suggested that daily use of GCE has a blood pressure-lowering effect in patients with mild hypertension.


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Correspondence to Kazuya Kozuma.

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Kozuma, K., Tsuchiya, S., Kohori, J. et al. Antihypertensive Effect of Green Coffee Bean Extract on Mildly Hypertensive Subjects. Hypertens Res 28, 711–718 (2005).

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  • hypertension
  • chlorogenic acid
  • dose-response
  • human
  • randomized controlled study

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