Abstract
The role of Helicobacter pylori in the pathogenesis of atherosclerosis remains controversial, and the relationship between H. pylori and the early stage of atherosclerosis has not been fully investigated. We investigated the influence of H. pylori infection on arterial stiffness to clarify whether H. pylori infection is related to early-stage atherosclerosis. The subjects were 3,412 males and 854 females. Anti-H. pylori antibody and C-reactive protein (CRP) level were measured. Arterial stiffness was evaluated using the brachial-ankle pulse wave velocity (PWV). In multivariate logistic repression analyses of male subjects, H. pylori seropositivity (odds ratio [OR] 1.27 [95% confidence interval, 1.05–1.52]) and H. pylori seropositivity with a high CRP value (>0.045 mg/dl) (OR 1.50 [1.14–1.98]) were significantly related to a high value of PWV. In the analyses of male subjects aged ≤49 years, H. pylori seropositivity (OR 1.40 [1.04–1.88]) and H. pylori seropositivity with a high CRP value (OR 1.81 [1.16–2.80]) were also significantly related to a high value of PWV. However, in male subjects aged ≥50 years and female subjects, no associations were found. These results suggest that inflammation following H. pylori infection contributes to the early stage of atherosclerosis in younger males.
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Ross R : Atherosclerosis—an inflammatory disease. N Engl J Med 1999; 340: 115–126.
The EUROGAST Study Group : Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut 1993; 34: 1672–1676.
Mendall MA, Goggin PM, Molineaux N, et al: Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994; 71: 437–439.
Markus HS, Mendall MA : Helicobacter pylori infection: a risk factor for ischaemic cerebrovascular disease and carotid atheroma. J Neurol Neurosurg Psychiatry 1998; 64: 104–107.
Ridker PM, Danesh J, Youngman L, et al: A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar U.S. men. Ann Intern Med 2001; 135: 184–188.
Lehmann ED : Clinical value of aortic pulse-wave velocity measurement. Lancet 1999; 354: 528–529.
Asmar R, Benetos A, Topouchian J, et al: Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 1995; 26: 485–490.
Laurent S, Katsahian S, Fassot C, et al: Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 2003; 34: 1203–1206.
Laurent S, Boutouyrie P, Asmar R, et al: Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37: 1236–1241.
Guerin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM : Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 2001; 103: 987–992.
Kawai T, Kawakami K, Kudo T, Ogiahara S, Handa Y, Moriyasu F : A new serum antibody test kit (E plate) for evaluation of Helicobacter pylori eradication. Intern Med 2002; 41: 780–783.
Yamashina A, Tomiyama H, Takeda K, et al: Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002; 25: 359–364.
Tomiyama H, Yamashina A, Arai T, et al: Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 2003; 166: 303–309.
Imanishi R, Seto S, Toda G, et al: High brachial-ankle pulse wave velocity is an independent predictor of the presence of coronary artery disease in men. Hypertens Res 2004; 27: 71–78.
Kinjo K, Sato H, Sato H, et al: Osaka Acute Coronary Insufficiency Study (OACIS) Group: Prevalence of Helicobacter pylori infection and its link to coronary risk factors in Japanese patients with acute myocardial infarction. Circ J 2002; 66: 805–810.
Osawa H, Kawakami M, Fujii M, et al: Helicobacter pylori infection and coronary heart disease in Japanese patients. Cardiology 2001; 95: 14–19.
El-Omar EM, Carrington M, Chow W-H, et al: Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404: 398–402.
Furuta T, El-Omar EM, Xiao F, Shirai N, Takashima M, Sugimura H : Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 2002; 123: 92–105.
Prospective Studies Collaboration: Cholesterol, diastolic blood pressure, and stroke : Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts. Prospective studies collaboration. Lancet 1995; 346: 1647–1653.
Parish S, Collins R, Peto R, et al: Cigarette smoking, tar yields, and non-fatal myocardial infarction: 14,000 cases and 32,000 controls in the United Kingdom. The International Studies of Infarct Survival (ISIS) Collaborators. BMJ 1995; 311: 471–477.
Adachi K, Arima N, Takashima T, et al: Pulse-wave velocity and cardiovascular risk factors in subjects with Helicobacter pylori infection. J Gastroenterol Hepatol 2003; 18: 771–777.
Farsak B, Yildirir A, Akyon Y, et al: Detection of Chlamydia pneumoniae and Helicobacter pylori DNA in human atherosclerotic plaques by PCR. J Clin Microbiol 2000; 38: 4408–4411.
Ameriso SF, Fridman EA, Leiguarda RC, Sevlever GE : Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 2001; 32: 385–391.
Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI : Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991; 32: 1473–1477.
Moss SF, Legon S, Davies J, Calam J : Cytokine gene expression in Helicobacter pylori associated antral gastritis. Gut 1994; 35: 1567–1570.
Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC : C-reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. BMJ 1996; 312: 1061–1065.
Zhang ZW, Patchett SE, Perrett D, Domizio P, Farthing MJ : Gastric alpha-tocopherol and beta-carotene concentrations in association with Helicobacter pylori infection. Eur J Gastroenterol Hepatol 2000; 12: 497–503.
Stringer MD, Gorog PG, Freeman A, Kakkar VV : Lipid peroxides and atherosclerosis. BMJ 1989; 298: 281–284.
Hayward CS, Kelly RP, Collins P : The roles of gender, the menopause and hormone replacement on cardiovascular function. Cardiovasc Res 2000; 46: 28–49.
Yamada S, Gotoh T, Nakashima Y, et al: Distribution of serum C-reactive protein and its association with atherosclerotic risk factors in a Japanese population: Jichi Medical School Cohort Study. Am J Epidemiol 2001; 153: 1183–1190.
Yamaji Y, Mitsushima T, Ikuma H, et al: Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis of 5732 Japanese subjects. Gut 2001; 49: 335–340.
Danesh J, Collins R, Peto R : Chronic infections and coronary heart disease: is there a link? Lancet 1997; 350: 430–436.
Ridker PM, Cannon CP, Morrow D, et al: Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators: C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005; 352: 20–28.
Albert MA, Danielson E, Rifai N, Ridker PM, PRINCE Investigators : Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA 2001; 286: 64–70.
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Saijo, Y., Utsugi, M., Yoshioka, E. et al. Relationship of Helicobacter pylori Infection to Arterial Stiffness in Japanese Subjects. Hypertens Res 28, 283–292 (2005). https://doi.org/10.1291/hypres.28.283
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DOI: https://doi.org/10.1291/hypres.28.283
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