Figure 1

From: Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz–Jeghers syndrome harboring genomic deletion of the STK11 gene

Figure 1

Genetic analysis of the STK11 gene and protein expression in the Peutz–Jeghers syndrome (PJS) patient. (a) Pedigree of the PJS patient. (b) Electropherograms of the STK11 splicing variant. The STK11 splicing variant was identified in the PJS patient by reverse transcription-PCR/direct sequencing with puromycin (upper panel). No splicing variant was detected in the subject without puromycin treatment (lower panel). (c) Immunohistochemistry for STK11 in the normal endometrium (left) and cervical adenocarcinoma (right). STK11 protein localization was diminished in the cervical adenocarcinoma.