Summary
Interactions of a neutral polymorphic locus with a heterotic locus are investigated. In particular, deviations from Hardy-Weinberg expectations at the neutral locus are investigated. The amount of deviation is shown to be determined by the amount of linkage disequilibrium between alleles at the loci and the strength of heterosis at the selected locus. Under some conditions apparent selection coefficients can be determined for the genotypes at the neutral locus. Actually observed deviations from H-W for enzyme loci are discussed. From the results of the present investigation, it seems unlikely that the heterozygote excesses observed at these loci can be accounted for by associative over-dominance alone.
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Frydenberg, O. 1963. Population studies of a lethal mutant in Drosophila melanogaster. I. Bevahior in populations with discrete generations. Hereditas, 50, 89–119.
Lerner, I M. 1958. The Genetic Basis of Selection. Wiley, New York.
Lewontin, R C, and Cockerham, C C. 1959. The goodness-of-fit test for detecting natural selection in random mating populations. Evolution, 13, 561–564.
Lewontin, R C, and Kojima, K. 1960. The evolutionary dynamics of complex polymorphisms. Evolution, 14, 458–472.
Ohta, T, and Kimura, M. 1970. Development of associative overdominance through linkage disequilibrium in finite populations. Genet Res Camb, 16, 165–177.
Powell, J R. 1974. Heterosis at an enzyme locus of Drosophila: Evidence from experimental populations. Heredity, 32, 105–108.
Richmond, R C, and Powell, J R. 1970. Evidence of heterosis associated with an enzyme locus in a natural population of Drosophila. Proc Nat Acad Set USA, 67, 1264–1267.
Wills, C, and Nichols, L. 1971. Single-gene heterosis in Drosophila revealed by inbreeding. Nature, 233, 123–125.
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Powell, J. Interaction of genetic loci: the effect of linkage disequilibria on hardy-weinberg expectations. Heredity 32, 151–158 (1974). https://doi.org/10.1038/hdy.1974.18
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DOI: https://doi.org/10.1038/hdy.1974.18