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Axonal transport of adeno-associated viral vectors is serotype-dependent

Gene Therapy volume 20, pages 348–352 (2013)Cite this article

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Abstract

We have previously shown that adeno-associated virus type 2 (AAV2) undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, in the same way as AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype dependent and this has implications for gene therapy of neurological diseases such as Huntington's disease.

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Acknowledgements

This work was supported by NIH grant R01NS073940 to KSB.

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Author notes

  1. E A Salegio and L Samaranch: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, University of California San Francisco, San Francisco, CA, USA

    E A Salegio, L Samaranch, A P Kells, G Mittermeyer, W San Sebastian, J Beyer, J Forsayeth & K S Bankiewicz

  2. Research Vector Core, Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia, Philadelphia, PA, USA

    S Zhou

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  1. E A Salegio
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  2. L Samaranch
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  3. A P Kells
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  4. G Mittermeyer
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  5. W San Sebastian
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  6. S Zhou
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  7. J Beyer
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  8. J Forsayeth
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  9. K S Bankiewicz
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Correspondence to K S Bankiewicz.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on Gene Therapy website

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Salegio, E., Samaranch, L., Kells, A. et al. Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther 20, 348–352 (2013). https://doi.org/10.1038/gt.2012.27

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