Table 3 Results of the one-way sensitivity analyses

From: Cost-effectiveness analysis of germ-line BRCA testing in women with breast cancer and cascade testing in family members of mutation carriers

Scenario Incremental cost Incremental QALYs ICER/QALY
Scenario 1: Testing affected women only
 Base case AU$1,880 0.10 AU$18,900
 Mean age affected individual 30 years AU$1,837 0.08 AU$22,209
 Mean age affected individual 50 years AU$1,811 0.14 AU$13,221
 Probability of BRCA mutation 5% AU$1,427 0.03 AU$43,039
 Probability of BRCA mutation 20% AU$2,106 0.13 AU$15,886
 Breast and ovarian cancer risks in women tested negative obtained from BOADICEA model AU$1,880 0.10 AU$18,900
 Uptake rate of BRCA testing is 50% AU$1,450 0.05 AU$29,161
 Uptake of RRM alone 24%, RRBSO 43%, RRBSO+RRM 13%, and surveillance 20% AU$1,770 0.08 AU$21,898
 Discount rate 3% AU$1,755 0.15 AU$11,853
 Disutility of mastectomy 0.05 AU$1,880 0.10 AU$19,095
 Disutility of oophorectomy 0.05 AU$1,880 0.10 AU$19,703
 Surveillance using annual MRI AU$2,312 0.10 AU$23,257
Scenario 2: Testing affected individuals and cascade testing in family members of mutation carriers
 Base case AU$2,535 0.17 AU$15,011
 Start age affected 30 AU$2,571 0.14 AU$18,225
 Start age affected 50 AU$2,430 0.22 AU$11,767
 Probability of BRCA mutation 5% AU$1,645 0.06 AU$29,225
 Probability of BRCA mutation 20% AU$2,979 0.23 AU$13,233
 Breast and ovarian cancer risks in women tested negative obtained from BOADICEA model AU$2,535 0.17 AU$15,011
 Uptake rate of BRCA testing is 50% AU$1,777 0.08 AU$21,052
 Uptake of RRM alone 24%, RRBSO 43%, RRBSO+RRM 13%, and surveillance 20% AU$2,260 0.14 AU$16,394
 Discount rate 3% AU$2,308 0.28 AU$8,363
 Disutility of mastectomy 0.05 AU$2,535 0.16 AU$15,300
 Disutility of oophorectomy 0.05 AU$2,535 0.16 AU$15,883
 Surveillance using annual MRI AU$3,208 0.17 AU$18,868
  1. AU$, Australian dollar; ICER, incremental cost-effectiveness ratio; MRI, magnetic resonance imaging; QALY, quality-adjusted life-year; RRBSO, risk-reducing bilateral salpingo-oophorectomy; RRM, risk-reducing mastectomy.